| 301. |
- Wicher, Grzegorz, et al.
(författare)
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Extracellular clusterin promotes neuronal network complexity in vitro
- 2008
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Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 19:15, s. 1487-1491
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Tidskriftsartikel (refereegranskat)abstract
- Clusterin (apolipoprotein J), a highly conserved amphiphatic glycoprotein and chaperone, has been implicated in a wide range of physiological and pathological processes. As a secreted protein, clusterin has been shown to act extracellularly where it is involved in lipid transportation and clearance of cellular debris. Intracellularly, clusterin may regulate signal transduction and is upregulated after cell stress. After neural injury, clusterin may be involved in nerve cell survival and postinjury neuroplasticity. In this study, we investigated the role of extracelullar clusterin on neuronal network complexity in vitro. Quantitative analysis of clustrin-treated neuronal cultures showed significantly higher network complexity. These findings suggest that in addition to previously demonstrated neuroprotective roles, clusterin may also be involved in neuronal process formation, elongation, and plasticity.
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| 302. |
- Wicher, Grzegorz, et al.
(författare)
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Megalin deficiency induces critical changes in early glial development in mouse spinal cord
- 2008
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Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 19:5, s. 559-563
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Tidskriftsartikel (refereegranskat)abstract
- Low density lipoprotein receptor-related protein, megalin, is a multifunctional lipoproptein receptor expressed by absorptive epithelia for endocytosis of numerous ligands. Megalin is widely expressed during embryonic life and is essential for development of the nervous system as evidenced by severe forebrain abnormalities in megalin (-/-). Here, we investigated the influence of megalin deficiency on prenatal spinal cord development in mice. In contrast to wild-type mice, cells expressing Olig2 and NG2, that is, oligodendroglial precursor cells, are absent from embryonic stage E16 in megalin (-/-) mice. At the end of prenatal development, there is a failure in vertebral development, and the number of astrocytes are markedly reduced in megalin (-/-) mice. These findings indicate that megalin is essential in astro-oligodendroglial interactions during development of the spinal cord.
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| 303. |
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| 304. |
- Widerberg, Annika, et al.
(författare)
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Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts.
- 2002
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Ingår i: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 1473-558X .- 0959-4965. ; 13:4, s. 371-375
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Tidskriftsartikel (refereegranskat)abstract
- One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts.
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| 305. |
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| 306. |
- Wik, G, et al.
(författare)
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Magnetic brain imaging of extinction processes in human classical conditioning
- 1997
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Ingår i: NEUROREPORT. - : RAPID SCIENCE PUBLISHERS. - 0959-4965. ; 8:7, s. 1789-1792
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Tidskriftsartikel (refereegranskat)abstract
- BY recording neuromagnetic events during aversive classical conditioning, we examined the extinction of a previously described conditioned response. Averaging over non-reinforced exposures to the conditioned stimulus revealed magnetic activity in the sec
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| 307. |
- Wik, G, et al.
(författare)
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Magnetic imaging in human classical conditioning
- 1996
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Ingår i: NEUROREPORT. - : RAPID SCIENCE PUBLISHERS. - 0959-4965. ; 7:3, s. 737-740
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Tidskriftsartikel (refereegranskat)abstract
- MAGNETOENCEPHALOGRAPHY (MEG) was recorded during aversive classical conditioning in an attempt to elucidate the temporal coding of primary somatosensory cortex (SI) activation previously found with positron emission tomography. Four healthy volunteers pa
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| 308. |
- Wik, Gustav, et al.
(författare)
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Retrosplenial cortical activation in the fibromyalgia syndrome.
- 2003
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Ingår i: Neuroreport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965. ; 14:4, s. 619-21
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Tidskriftsartikel (refereegranskat)abstract
- To study the CNS in chronic muscular pain typical of fibromyalgia we compared PET measures of regional cerebral blood flow (rCBF) in eight fibromyalgic patients and controls at rest. Higher rCBF for patients than controls was found bilaterally in the retrosplenial cortex. Lower rCBF for patients than controls were seen in the left frontal, temporal, parietal, and occipital cortices. The higher retroplenial rCBF in patients than controls may reflect increased attention towards sub-noxious somatosensory signaling, and agrees with the notion that fibromyalgic pain reflects secondary hyperalgesia. The brain regions with lower rCBF in fibromyalgic patients than controls participate in the normal cognitive processing of pain, which may be dysfunctional in fibromyalgia.
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| 309. |
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| 310. |
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