SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1061 4036 "

Sökning: L773:1061 4036

  • Resultat 61-70 av 655
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  • Byun, Jinyoung, et al. (författare)
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
  • 2022
  • Ingår i: Nature Genetics. - : Nature Research. - 1061-4036 .- 1546-1718. ; 54:8, s. 1167-1177
  • Tidskriftsartikel (refereegranskat)abstract
    • To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
  •  
62.
  •  
63.
  •  
64.
  •  
65.
  • Cámara, Miguel, et al. (författare)
  • Quorum sensing in Vibrio cholerae.
  • 2002
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718.
  • Annan publikation (refereegranskat)
  •  
66.
  • Campbell, C D, et al. (författare)
  • Demonstrating stratification in a European American population
  • 2005
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 37:8, s. 868-872
  • Tidskriftsartikel (refereegranskat)abstract
    • Population stratification occurs in case-control association studies when allele frequencies differ between cases and controls because of ancestry. Stratification may lead to false positive associations, although this issue remains controversial(1-4). Empirical studies have found little evidence of stratification in European-derived populations, but potentially significant levels of stratification could not be ruled out(5-7). We studied a European American panel discordant for height, a heritable trait that varies widely across Europe(8). Genotyping 178 SNPs and applying standard analytical methods(6,9-11) yielded no evidence of stratification. But a SNP in the gene LCT that varies widely in frequency across Europe(12) was strongly associated with height (P < 10(-6)). This apparent association was largely or completely due to stratification; rematching individuals on the basis of European ancestry greatly reduced the apparent association, and no association was observed in Polish or Scandinavian individuals. The failure of standard methods to detect this stratification indicates that new methods may be required.
  •  
67.
  • Cao, Jun, et al. (författare)
  • Whole-genome sequencing of multiple Arabidopsis thaliana populations.
  • 2011
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 956-63
  • Tidskriftsartikel (refereegranskat)abstract
    • The plant Arabidopsis thaliana occurs naturally in many different habitats throughout Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse environments, a 1001 Genomes Project to sequence geographically diverse A. thaliana strains has been initiated. Here we present the first phase of this project, based on population-scale sequencing of 80 strains drawn from eight regions throughout the species' native range. We describe the majority of common small-scale polymorphisms as well as many larger insertions and deletions in the A. thaliana pan-genome, their effects on gene function, and the patterns of local and global linkage among these variants. The action of processes other than spontaneous mutation is identified by comparing the spectrum of mutations that have accumulated since A. thaliana diverged from its closest relative 10 million years ago with the spectrum observed in the laboratory. Recent species-wide selective sweeps are rare, and potentially deleterious mutations are more common in marginal populations.
  •  
68.
  •  
69.
  •  
70.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 655
Typ av publikation
tidskriftsartikel (652)
annan publikation (2)
recension (1)
Typ av innehåll
refereegranskat (608)
övrigt vetenskapligt/konstnärligt (47)
Författare/redaktör
Stefansson, K (63)
Groop, Leif (53)
Stefansson, Kari (49)
Lind, Lars (38)
Thorleifsson, Gudmar (38)
Thorsteinsdottir, Un ... (38)
visa fler...
Uitterlinden, AG (37)
McCarthy, Mark I (37)
Thorsteinsdottir, U (36)
Uitterlinden, André ... (35)
Melander, Olle (34)
Gieger, Christian (34)
Esko, T (34)
Metspalu, A (34)
Salomaa, Veikko (33)
Wareham, Nicholas J. (33)
Hofman, Albert (33)
Martin, NG (32)
Mohlke, Karen L (32)
Hayward, C. (32)
Loos, Ruth J F (32)
Boomsma, DI (31)
Ripke, S (31)
Lindgren, Cecilia M. (31)
Gudnason, V (30)
Hofman, A (30)
Deloukas, Panos (30)
Boehnke, Michael (30)
Thorleifsson, G (30)
Gieger, C (30)
Hayward, Caroline (30)
Montgomery, GW (29)
Easton, DF (29)
Luan, Jian'an (29)
Wilson, James F. (29)
Laakso, Markku (28)
Rivadeneira, Fernand ... (28)
Gudnason, Vilmundur (28)
Morris, Andrew P. (28)
Sullivan, PF (27)
van Duijn, CM (27)
Tuomilehto, Jaakko (27)
Harris, Tamara B (27)
Hottenga, JJ (26)
Rudan, Igor (26)
Hansen, Torben (26)
van Duijn, Cornelia ... (26)
Kraft, P (26)
Metspalu, Andres (26)
Zhao, Jing Hua (26)
visa färre...
Lärosäte
Karolinska Institutet (431)
Uppsala universitet (187)
Lunds universitet (168)
Umeå universitet (82)
Göteborgs universitet (74)
Örebro universitet (17)
visa fler...
Stockholms universitet (14)
Linköpings universitet (11)
Sveriges Lantbruksuniversitet (9)
Handelshögskolan i Stockholm (8)
Mittuniversitetet (4)
Högskolan Dalarna (4)
Kungliga Tekniska Högskolan (3)
Jönköping University (3)
Chalmers tekniska högskola (3)
Luleå tekniska universitet (1)
Mälardalens universitet (1)
visa färre...
Språk
Engelska (655)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (320)
Naturvetenskap (69)
Lantbruksvetenskap (5)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy