SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1107 3756 OR L773:1791 244X "

Sökning: L773:1107 3756 OR L773:1791 244X

  • Resultat 131-140 av 149
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
131.
  •  
132.
  •  
133.
  •  
134.
  • Strandhagen, Elisabeth, 1960, et al. (författare)
  • The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.
  • 2004
  • Ingår i: International journal of molecular medicine. - 1107-3756. ; 13:6, s. 811-5
  • Tidskriftsartikel (refereegranskat)abstract
    • Some methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are associated with hyperhomocysteinemia. Trials have shown a plasma homocysteine raising effect of coffee. We determined the effect of a daily intake of 600 ml coffee and a supplementation of 200 microg folic acid or placebo on plasma homocysteine (tHcy) with respect to the MTHFR C677T and A1298C polymorphisms. One hundred and twenty healthy, non-smoking men (22%) and women (78%) aged 29-65 years, took part in a controlled, randomized, blinded study with two intervention periods: i) a coffee-free period of three weeks, ii) 600 ml coffee/day and a supplement of 200 microg folic acid/d or placebo for four weeks. The results showed that tHcy at baseline was significantly higher for the 677TT genotype group compared to the 677CC genotype group (p=0.0045) and that this group responded with significantly larger increase in tHcy upon coffee exposure than the 677CC and 677CT genotype groups (p=0.0045 and p=0.0041, respectively). Supplementation with 200 microg folic acid compared to placebo reduced the tHcy increasing effect of coffee in the 677TT genotype group. The A1298C polymorphism did not affect tHcy concentration significantly at any stage in the study. In conclusion, the homocysteine increasing effect of coffee is particularly seen in individuals with the homozygous 677TT genotype. Supplementation with 200 microg folic acid/d decreases this tHcy increment.
  •  
135.
  •  
136.
  •  
137.
  •  
138.
  •  
139.
  • Svensson, Per-Arne, 1969, et al. (författare)
  • Urokinase-type plasminogen activator receptor is associated with macrophages and plaque rupture in symptomatic carotid atherosclerosis.
  • 2008
  • Ingår i: International journal of molecular medicine. - : Spandidos Publications. - 1107-3756. ; 22:4, s. 459-64
  • Tidskriftsartikel (refereegranskat)abstract
    • There is a strong correlation between macrophage infiltration and plaque instability in recently symptomatic carotid atherosclerotic plaques, and it is hypothesised that mechanisms related to macrophages may be involved in plaque vulnerability and rupture. We previously found high expression of urokinase-type plasminogen activator receptor (UPAR) in human macrophages. The aim of this study was to investigate whether UPAR co-localises with macrophages in symptomatic carotid plaques, and whether UPAR expression is associated with plaque rupture. Real-time RT-PCR assays showed that UPAR expression levels were high in monocyte-derived macrophages and in carotid endarterectomies compared with a tissue panel. Serial transverse sections were prepared from carotid endarterectomies from 12 symptomatic patients, and analyzed with immunohistochemical staining for UPAR and for CD68-positive macrophages, and with histopathological assessment. UPAR co-localised with CD68-positive macrophages, with a high correlation (r=0.90, p<0.001) between immunostained areas in 12 carotid endarterectomies from symptomatic patients. High degrees of UPAR and CD68 staining were found in sections around the bifurcation level where rupture was most common, while low degrees of staining were found in sections of the common carotid artery end of the endarterectomy (p<0.05). Higher degrees of UPAR staining were observed in ruptured plaque sections compared with non-ruptured sections. In conclusion, UPAR was highly expressed in monocyte-derived macrophages and in symptomatic carotid plaques, UPAR co-localised with macrophages in carotid symptomatic plaques and UPAR was predominantly found in ruptured plaque segments. These findings support the hypothesis that UPAR is related to plaque rupture in symptomatic atherosclerotic lesions.
  •  
140.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 131-140 av 149
Typ av publikation
tidskriftsartikel (105)
konferensbidrag (41)
forskningsöversikt (3)
Typ av innehåll
refereegranskat (92)
övrigt vetenskapligt/konstnärligt (57)
Författare/redaktör
Larsson, C (10)
Nordlind, K (5)
Klein, G (4)
Zetterberg, Henrik, ... (4)
Tolmachev, Vladimir (4)
Hamsten, A (4)
visa fler...
Ehrenborg, E (4)
Blennow, Kaj, 1958 (3)
Orlova, Anna (3)
Lindblom, A (3)
Kytola, S (3)
Eriksson, T (3)
Eriksson, P (3)
Mints, M (3)
Nilsson, S. (3)
Carlsson, Lena M S, ... (3)
Svensson, Per-Arne, ... (3)
Chen, L (2)
Liu, T. (2)
Weber, G. (2)
Backdahl, M (2)
Mustafa, M (2)
Bakhiet, M (2)
Rutqvist, LE (2)
Kogner, P (2)
Li, C. (2)
Pan-Hammarstrom, Q (2)
Caridha, R (2)
Ibrahim, S (2)
Sun, Xiao-Feng, 1959 ... (2)
Iverfeldt, Kerstin (2)
Franck, J (2)
Fagerberg, Björn, 19 ... (2)
Lennartsson, Johan (2)
Agnati, LF (2)
Guidolin, D (2)
Maura, G (2)
Marcoli, M (2)
Palmblad, J (2)
Tran, Thuy (2)
Eriksson, Per (2)
Chen, LY (2)
Ahrlund-Richter, A (2)
Grun, N (2)
Ramqvist, T (2)
Dalianis, T (2)
Du, J (2)
Ostman, A (2)
Kannisto, K (2)
Marquez, M (2)
visa färre...
Lärosäte
Karolinska Institutet (100)
Uppsala universitet (21)
Göteborgs universitet (13)
Linköpings universitet (11)
Umeå universitet (10)
Örebro universitet (7)
visa fler...
Lunds universitet (7)
Jönköping University (6)
Kungliga Tekniska Högskolan (4)
Chalmers tekniska högskola (4)
Stockholms universitet (2)
Gymnastik- och idrottshögskolan (1)
visa färre...
Språk
Engelska (148)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (35)
Naturvetenskap (4)
Teknik (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy