| 1011. |
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| 1012. |
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| 1013. |
- Schaufelberger, Maria, 1954, et al.
(författare)
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Heart failure in different occupational classes in Sweden
- 2007
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Ingår i: Eur Heart J. - : Oxford University Press (OUP). - 0195-668X. ; 28:2, s. 212-8
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: The link between low socioeconomic status (SES) and coronary heart disease (CHD) is well established, but there is a paucity of data whether a similar relation exists for heart failure (HF). METHODS AND RESULTS: A total of 6999 men 47-55 years old, without a prior stroke or myocardial infarction, from a population sample of 9998 men, were investigated during 1970-73. Over a 28-year follow-up, 1004 men (14.3%) were discharged from hospital or died with a diagnosis of HF. There was an inverse relationship between SES, measured as an occupational class, and future risk of HF. Compared with men in the highest occupational class, men with intermediate non-manual occupations had a multiple-adjusted hazard ratio (HR) of 1.28, 95% confidence interval (CI) 0.98-1.67, lower officials and foremen had an HR of 1.57 (1.22-2.03), semiskilled and skilled workers 1.48 (1.15-1.89), and unskilled workers 1.72 (1.34-2.20). Results were similar if only men with a principal diagnosis of HF (n=516) were considered, irrespective of whether a diagnosis of acute myocardial infarction or coronary revascularization had been recorded at any time. CONCLUSION: Low SES is an independent risk factor for long-term risk of HF in men.
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| 1014. |
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| 1015. |
- Schierbeck, Sofia, et al.
(författare)
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Automated external defibrillators delivered by drones to patients with suspected out-of-hospital cardiac arrest
- 2022
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; , s. 1478-1487
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Tidskriftsartikel (refereegranskat)abstract
- Aims Early defibrillation is critical for the chance of survival in out-of-hospital cardiac arrest (OHCA). Drones, used to deliver automated external defibrillators (AEDs), may shorten time to defibrillation, but this has never been evaluated in real-life emergencies. The aim of this study was to investigate the feasibility of AED delivery by drones in real-life cases of OHCA. Methods and results In this prospective clinical trial, three AED-equipped drones were placed within controlled airspace in Sweden, covering approximately 80 000 inhabitants (125 km(2)). Drones were integrated in the emergency medical services for automated deployment in beyond-visual-line-of-sight flights: (i) test flights from 1 June to 30 September 2020 and (ii) consecutive real-life suspected OHCAs. Primary outcome was the proportion of successful AED deliveries when drones were dispatched in cases of suspected OHCA. Among secondary outcomes was the proportion of cases where AED drones arrived prior to ambulance and time benefit vs. ambulance. Totally, 14 cases were eligible for dispatch during the study period in which AED drones took off in 12 alerts to suspected OHCA, with a median distance to location of 3.1 km [interquartile range (IQR) 2.8-3.4). AED delivery was feasible within 9 m (IQR 7.5-10.5) from the location and successful in 11 alerts (92%). AED drones arrived prior to ambulances in 64%, with a median time benefit of 01:52 min (IQR 01:35-04:54) when drone arrived first. In an additional 61 test flights, the AED delivery success rate was 90% (55/61). Conclusion In this pilot study, we have shown that AEDs can be carried by drones to real-life cases of OHCA with a successful AED delivery rate of 92%. There was a time benefit as compared to emergency medical services in cases where the drone arrived first. However, further improvements are needed to increase dispatch rate and time benefits.
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| 1016. |
- Schiopu, A., et al.
(författare)
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Galectin 3 is a powerful risk predictor for recurrent coronary events in acute coronary syndrome patients
- 2015
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 36:Suppl 1, s. 11-11
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Konferensbidrag (refereegranskat)abstract
- Background: Galectin 3 and ST2 are mediators and biomarkers of myocardial fibrosis and remodeling that have recently entered the clinical practice guidelines as prognostic factors in heart failure patients. Elevated galectin 3 and ST2 levels in acute myocardial infarction patients have also been associated with increased incidence of adverse events during follow-up. Purpose: We aimed to assess the comparative ability of Galectin 3 and ST2 to offer additional prognostic information for risk stratification in acute coronary syndrome (ACS) patients, on top of traditional cardiovascular risk factors and other established prognostic biomarkers. Methods: We measured the levels of galectin 3, ST2, N-terminal pro-B type natriuretic peptide (NTproBNP), high-sensitivity C-reactive protein (hsCRP), highsensitivity troponin T (TnT), cystatin C, and lipids in plasma collected from 524 ACS patients (STEMI, non-STEMI and unstable angina) on day 1 following the acute event. Biomarker levels were correlated with the risk to develop recurrent coronary events, in linear regression models adjusted for age, sex and traditional risk factors (smoking, diabetes mellitus, hypertension, LDL, HDL and triglycerides). Results: During a mean follow-up period of 2.13 years, 63 (12%) of the patients suffered a new coronary event. Baseline galectin 3, ST2, hsCRP, NTproBNP and cystatin C were significantly higher in these patients compared to the event-free controls. In a Cox proportional hazards model with forward step selection that included all biomarkers alongside traditional risk factors, age (HR per year of age 1.06, 95% CI 1.03-1.09), galectin 3 (HR per SD log increase 1.88, 95% CI 1.41- 2.51) and cystatin C (HR per SD log increase 1.39, 95% CI 1.12-1.74) were selected as the only independent predictors of recurrent events in the population. In receiver operating curve (ROC) analyses, addition of galectin 3 significantly improved the c-statistic of the model based on traditional risk factors alone (0.81 vs. 0.76, P
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| 1017. |
- Schmid, Michael, et al.
(författare)
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A patient with ischaemic cardiomyopathy
- 2014
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 35:1, s. 41-41
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 1018. |
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| 1019. |
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| 1020. |
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