SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1529 0131 OR L773:0004 3591 "

Sökning: L773:1529 0131 OR L773:0004 3591

  • Resultat 11-20 av 870
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Akkoc, Nurullah, et al. (författare)
  • Increased Prevalence of M694V in Patients With Ankylosing Spondylitis : Additional Evidence for a Link With Familial Mediterranean Fever
  • 2010
  • Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 62:10, s. 3059-3063
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. To assess whether there is a statistically significant difference in the frequency of common MEFV allele variants in patients with ankylosing spondylitis (AS) as compared with control patients with rheumatoid arthritis (RA) and with healthy control subjects. Methods. Sixty-two patients with AS, 50 healthy control subjects, and 46 patients with RA were assessed for the presence of MEFV variants. Exon 10 was analyzed by direct sequencing. E148Q was analyzed by restriction endonuclease enzyme digestion (REED) or by direct sequencing when REED analysis failed. Results. The allele frequency of all MEFV variants in the AS group was significantly higher than that in the pooled control group of healthy subjects plus RA patients (15.3% versus 6.8%; P = 0.021). M694V was the only variant that was significantly more common in the AS group than in the combined or individual control groups (P = 0.026 for AS patients versus healthy controls, P = 0.046 for AS patients versus RA patient controls, and P = 0.008 for AS patients versus healthy and RA patient control groups). The carriage rate of M694V was also significantly higher in the AS patient group than in the combined control group (odds ratio 7.0, P = 0.014). Neither M694V nor any other MEFV variant showed a correlation with most of the disease-related measures examined. Conclusion. We found an increased frequency of MEFV variants in AS patients as compared with healthy controls and with RA patient controls. This was primarily due to the presence of M694V. The roles of other exon 10 variants, as well as the relationship between the variant status and the severity and clinical course of the disease, need to be explored in further studies that include sufficiently large sample sizes.
  •  
12.
  •  
13.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  • Amirahmadi, S. F., et al. (författare)
  • Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells
  • 2005
  • Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 52:6, s. 1897-1906
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Some monoclonal antibodies (mAb) to type II collagen (CII) are arthritogenic upon passive transfer to mice. We undertook this study to investigate whether such mAb are pathogenic in the absence of mediators of inflammation. METHODS: The arthritogenic mAb CIIC1 and M2139, and the nonarthritogenic mAb CIIF4, each reactive with a distinct and well-defined conformational epitope on CII, were compared with control mAb GAD6. Bovine chondrocytes were cultured with one of the mAb, and on days 3, 6, and 9, antibody binding by chondrocytes and newly synthesized extracellular matrix (ECM) was examined by immunofluorescence, morphologic effects were studied by electron microscopy, and synthesis of matrix components was determined by metabolic labeling with (3)H-proline for collagen and (35)S-sulfate for proteoglycans. RESULTS: All 3 mAb to CII bound to the matrix. CIIC1 and M2139 adversely affected the cultures, whereas CIIF4 did not. CIIC1 caused disorganization of CII fibrils in the ECM without affecting chondrocyte morphology, and increased matrix synthesis. M2139 caused thickening and aggregation of CII fibrils in the ECM and abnormal chondrocyte morphology but matrix synthesis was unaffected. CONCLUSION: The unique arthritogenic capacity of particular anti-CII mAb upon passive transfer could be explained by their adverse, albeit differing, effects in primary cultures of chondrocytes. Such effects occur independent of inflammation mediators and are related to the epitope specificity of the mAb. Interference with the structural integrity of CII could precede, and even initiate, the inflammatory expression of disease.
  •  
18.
  • Andersen, Grethe Neumann, et al. (författare)
  • Assessment of vascular function in systemic sclerosis : indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production
  • 2002
  • Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 46:5, s. 1324-1332
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To investigate the relationship between endothelium-dependent and endothelium-independent functions and the stiffness of conduit arteries as well as levels of endothelial activation markers in patients with systemic sclerosis (SSc). METHODS: Endothelium-dependent (i.e., flow-mediated) and endothelium-independent (i.e., nitroglycerin-induced) dilation of the brachial artery was measured as the percentage of change from baseline (FMD% and NTG%, respectively) in 24 SSc patients and 24 age- and sex-matched healthy controls by high-resolution ultrasound imaging. The maximum increase in systolic pressure per unit of time (dP/dt(max)), as a measure of arterial wall stiffness, was assessed in the radial artery by pulse applanation tonometry. Plasma nitrate, the most important metabolite of nitric oxide, and 24-hour urinary excretion of nitrate were measured by gas chromatography mass spectrometry. Soluble E-selectin and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured by enzyme-linked immunosorbent assay. RESULTS: Brachial artery FMD% and NTG% did not differ between SSc patients and controls. Radial artery dP/dt(max) was significantly increased in the patients and correlated significantly with elevated levels of plasma nitrate and sVCAM-1. Twenty-four-hour urinary nitrate excretion tended to be elevated. Brachial artery NTG% was significantly inversely correlated with levels of plasma nitrate and soluble endothelial adhesion molecules. CONCLUSION: The ability of the brachial arteries to dilate in response to hyperemia and nitroglycerin challenge is preserved in SSc. Stiffness of the radial artery is increased, however. Endothelial activation seems to determine the extent of the brachial artery NTG% and the radial artery dP/dt(max). The data are compatible with the hypothesis that nitrate tolerance is present in the vascular smooth muscle cells of the brachial artery wall in SSc.
  •  
19.
  • Andersen, Grethe Neumann, et al. (författare)
  • Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis : findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular adhesion molecule 1
  • 2000
  • Ingår i: Arthritis and Rheumatism. - 0004-3591 .- 1529-0131. ; 43:5, s. 1085-1093
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To determine the relationship between vascular function and the inflammatory response in systemic sclerosis (SSc), and to investigate whether production of endothelial-derived nitric oxide (NO) is disturbed in this disease. Methods We measured plasma nitrate, urinary excretion of both nitrate and cGMP, and soluble adhesion molecules of endothelial origin in patients with SSc and in age- and sex-matched controls and compared these levels between groups. Additionally, we performed correlation analysis to determine how these variables were related to one another. Plasma nitrate and 24-hour-urinary excretion of nitrate in patients and controls were measured after a 72-hour nitrate-free-diet, using a gas chromatography/mass spectrometric method. Soluble adhesion molecules intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1), and E-selectin and cytokines were measured by enzyme-linked immunosorbent assay. The expression of E-selectin was further investigated in skin biopsy specimens by immunoperoxidase staining, and the presence of inducible NO synthase by immunoblotting. Results Plasma nitrate and 24-hour-urinary-excretion of cGMP were significantly elevated in patients compared with controls, while 24-hour-urinary-excretion of nitrate tended to be elevated in SSc patients. Levels of sICAM-1, sVCAM-1, and sE-selectin were significantly elevated in the patients. Levels of plasma nitrate in the patients correlated significantly with levels of sVCAM-1 (P = 0.020) and sE-selectin (P = 0.018) and approached a significant correlation with sICAM-1 (P = 0.055), suggesting that activated endothelial cells may produce plasma nitrate. Conclusion NO synthesis is elevated in SSc patients, and the activated endothelial cell is a likely site of its production.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 870
Typ av publikation
tidskriftsartikel (450)
konferensbidrag (416)
forskningsöversikt (4)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (461)
refereegranskat (409)
Författare/redaktör
KLARESKOG, L (162)
van Vollenhoven, RF (91)
Lundberg, IE (70)
Alfredsson, L (47)
Padyukov, L (41)
Askling, J (40)
visa fler...
Gunnarsson, I (31)
van Vollenhoven, R (31)
Malmstrom, V (29)
Rönnblom, Lars (26)
Lundberg, I (26)
Klareskog, Lars (25)
Catrina, AI (25)
Holmdahl, Rikard (25)
Rantapää-Dahlqvist, ... (24)
Sturfelt, Gunnar (22)
Ulfgren, AK (22)
Svenungsson, E (22)
Emery, P. (22)
Alexanderson, H (22)
Saxne, Tore (22)
Eloranta, Maija-Leen ... (21)
van der Heijde, D (21)
Ramsey-Goldman, R (19)
Wahren-Herlenius, M (19)
Rönnelid, Johan (18)
Kallberg, H (18)
Petri, M. (18)
Saevarsdottir, S (17)
Alarcón-Riquelme, Ma ... (16)
Dastmalchi, M (16)
Ernestam, S (16)
Bengtsson, C (16)
Jacobsson, Lennart (16)
Andersson, U (15)
Hafstrom, I (15)
Frostegard, J (15)
Dahlqvist, Solbritt ... (15)
Askling, Johan (15)
Bratt, J (15)
Holmdahl, R (14)
Nandakumar, Kutty Se ... (14)
Steinsson, K (14)
Plenge, RM (14)
Lampa, J (13)
Ronnelid, J (13)
Englund, Martin (13)
Nived, Ola (13)
Holmqvist, M (13)
Geborek, P (13)
visa färre...
Lärosäte
Karolinska Institutet (598)
Lunds universitet (154)
Uppsala universitet (101)
Umeå universitet (69)
Göteborgs universitet (30)
Högskolan i Halmstad (23)
visa fler...
Linköpings universitet (13)
Sveriges Lantbruksuniversitet (6)
Kungliga Tekniska Högskolan (4)
Örebro universitet (3)
Linnéuniversitetet (2)
Högskolan i Gävle (1)
Mälardalens universitet (1)
Jönköping University (1)
Malmö universitet (1)
Högskolan i Skövde (1)
Försvarshögskolan (1)
Sophiahemmet Högskola (1)
visa färre...
Språk
Engelska (870)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (248)
Naturvetenskap (4)
Lantbruksvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy