| 50141. |
- Lindberg, Erika, 1979, et al.
(author)
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Impaired activation of IFN-gamma+CD4+ T cells in peripheral blood of patients with dilated cardiomyopathy
- 2010
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In: Cellular Immunology. - San Diego, USA : Elsevier. - 0008-8749 .- 1090-2163. ; 263:2, s. 224-229
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Journal article (peer-reviewed)abstract
- Viral persistence and autoantibodies are pathogenic components in patients with idiopathic dilated cardiomyopathy (DCM). The aim was to evaluate T-cell function in DCM using different flow cytometry based detection techniques. Following stimulation, the frequency of IFN-gamma-producing CD4+ T cells was significantly lower in patients compared with controls. In contrast, the frequency of IL-4 producing CD4+ T cells was no different. In supernatants of cultured PBMC, IFN-gamma and IL-10 were significantly lower in patients. In addition, lymphocyte proliferation was significantly lower in patients compared with controls, whereas major lymphocyte subsets were not different. IFN-gamma and IL-10 are key cytokines in the ability to mount protective immune responses and to maintain self-tolerance. A reduced activation of T-helper 1 (IFN-gamma producing) cells and a decreased capacity to produce IL-10, found in the present study, could explain parts of the autoimmune features seen in patients with DCM.
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| 50142. |
- Lindberg, Erika, 1976, et al.
(author)
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Long-time persistence of superantigen-producing Staphylococcus aureus strains in the intestinal microflora of healthy infants.
- 2000
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In: Pediatric research. - 0031-3998. ; 48:6, s. 741-7
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Journal article (peer-reviewed)abstract
- Staphylococcus aureus has been isolated at an increasing rate from infants' stools during the last decades, but it is not known whether this species can colonize and persist in the intestinal microflora. To investigate this, 49 Swedish infants were followed prospectively from birth until 12 months of age. S. aureus was identified in a rectal swab obtained 3 d after delivery and in quantitative cultures of fecal samples collected at 1, 2, 4, and 8 weeks and at 6 and 12 months of age. A random amplified polymorphic DNA (RAPD) method was developed to distinguish individual S. aureus strains from one another and the strains were tested for production of enterotoxins A-D and TSST-1. By 3 days of age, 16% of infants had S. aureus in their intestines, which increased to 73% by 2-6 months, whereafter it decreased slightly to 53%. At the same time S. aureus population counts in colonized infants declined from an average 10(6.8) CFU/g feces during the first months of life to 10(4.0) CFU/g feces by 12 months. Colonized infants usually harbored one or two S. aureus strains in their microflora for long periods of time. Few strains were transient passengers and the median time of persistence of S. aureus strains in the microflora was several months. Of the 75 S. aureus strains identified, 43% produced one or more toxins: 13% SEA, 7% SEB, 23% SEC, 4% SED, and 11% TSST-1. Altogether, 47% of the investigated infants were colonized by a toxin-producing S. aureus during their first year of life. Despite this they were apparently healthy and did not have more gastrointestinal problems than noncolonized infants. This report is the first to show that S. aureus may be a resident member of the normal intestinal microflora in infancy.
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| 50143. |
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| 50144. |
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| 50145. |
- Lindberg, Erika, 1976, et al.
(author)
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Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
- 2019
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Journal article (peer-reviewed)abstract
- Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively.
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| 50146. |
- Lindberg, Fredrik, 1974, et al.
(author)
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Characteristics of the mean radiant temperature in high latitude cities—implications for sensitive climate planning applications
- 2014
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In: International Journal Of Biometeorology. - : Springer Science and Business Media LLC. - 0020-7128 .- 1432-1254. ; 58:5
-
Journal article (peer-reviewed)abstract
- Knowledge of how the mean radiant temperature (T mrt ) is affected by factors such as location, climate and urban setting contributes to the practice of climate sensitive planning. This paper examines how T mrt varies within an urban setting and how it is influenced by cloudiness. In addition, variations of T mrt in three high latitude cities are investigated in order to analyse the impact of geographical context and climate conditions. Results showed large spatial variations between sunlit and shaded areas during clear weather conditions, with the highest values of T mrt close to sunlit walls and the lowest values in the areas shaded by buildings and vegetation. As cloudiness increases, the spatial pattern is altered and the differences are reduced. The highest T mrt under cloudy conditions is instead found in open areas where the proportion of shortwave diffuse radiation from the sky vault is high. A regional comparison between three Swedish coastal cities showed that T mrt during summer is similar regardless of latitudinal location. On the other hand, large differences in T mrt during winter were found. Shadows, both from buildings and vegetation are the most effective measure to reduce extreme values of T mrt . However, extensive areas of shadow are usually not desired within outdoor urban environments at high latitude cities. One solution is to create diverse outdoor urban spaces in terms of shadow and also ventilation. This would provide individuals with access to a choice of thermal environments which they can use to assist their thermal regulation, based on personal needs and desires.
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| 50147. |
- Lindberg, Fredrik, et al.
(author)
-
Hydroxylapatite growth on single-crystal rutile substrates
- 2008
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In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 29:23, s. 3317-3323
-
Journal article (peer-reviewed)abstract
- Titanium is widely used as an implant material. In addition to the bulk properties of titanium, the biological response is to a large degree controlled via the surface. The native amorphous titanium oxide that forms spontaneously on the surface gives a very good biological response. Lately it has been shown that crystalline titanium oxides (rutile and anatase) have in vitro bioactive properties. In addition to its potential for new materials development, this finding also opens up for the possibility of studying the mechanisms of bioactivity on materials with strictly controlled surfaces. In this paper the mechanisms behind the in vitro bioactivity are studied, using rutile single crystals. Three single-crystal rutile substrates: (100), (110), and (001), and a polycrystalline rutile substrate obtained by physical vapour deposition were soaked in a phosphate buffered saline solution for up to 4 weeks. The hydroxylapatite films that formed were analysed by X-ray diffraction, scanning electron microscopy, focused ion beam, and transmission electron microscopy. The hydroxylapatite grew faster on the (001) surface than on the other two. It was also found that on the (001) surface the direction of fast growth in hydroxylapatite was aligned parallel to the surface. This is in contrast to the (110) rutile surface where the fast growth of the hydroxylapatite crystal was directed outwards from the surface. The (100) face had poor adhesion at the interface. The orientations of the precipitated crystallites play a significant role in the faster coverage of the (001) rutile face. Based on the experimental results, a model for the hydroxylapatite growth process is given.
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| 50148. |
- Lindberg, Fredrik, 1974, et al.
(author)
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Impact of city changes and weather on anthropogenic heat flux in Europe 1995–2015
- 2013
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In: Urban Climate. - 2212-0955. ; 4, s. 1-15
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Journal article (peer-reviewed)abstract
- How people live, work, move from place to place, consume and the technologies they use all affect heat emissions in a city which influences urban weather and climate. Here we document changes to a global anthropogenic heat flux (QF) model to enhance its spatial (30'' x 30'' to 0.5° x 0.5°) resolution and temporal coverage (historical, current and future). QF is estimated across Europe (1995–2015), considering changes in temperature, population and energy use. While on average QF is small (of the order 1.9–4.6Wm2 across all the urban areas of Europe), significant spatial variability is documented (maximum 185Wm2). Changes in energy consumption due to changes in climate are predicted to cause a 13% (11%) increase in QF on summer (winter) weekdays. The largest impact results from changes in temperature conditions which influences building energy use; for winter, with the coldest February on record, the mean flux for urban areas of Europe is 4.56 W m-2 and for summer (warmest July on record) is 2.23 W m-2. Detailed results from London highlight the spatial resolution used to model the QF is critical and must be appropriate for the application at hand, whether scientific understanding or decision making.
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| 50149. |
- Lindberg, Fredrik, 1974, et al.
(author)
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Influence of ground surface characteristics on the mean radiant temperature in urban areas
- 2016
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In: International Journal of Biometeorology. - : Springer Science and Business Media LLC. - 0020-7128 .- 1432-1254. ; 60:9, s. 1439-1452
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Journal article (peer-reviewed)abstract
- The effect of variations in land cover on mean radiant temperature (T-mrt) is explored through a simple scheme developed within the radiation model SOLWEIG. Outgoing longwave radiation is parameterised using surface temperature observations on a grass and an asphalt surface, whereas outgoing shortwave radiation is modelled through variations in albedo for the different surfaces. The influence of ground surface materials on T-mrt is small compared to the effects of shadowing. Nevertheless, altering ground surface materials could contribute to a reduction in T-mrt to reduce the radiant load during heat-wave episodes in locations where shadowing is not an option. Evaluation of the new scheme suggests that despite its simplicity it can simulate the outgoing fluxes well, especially during sunny conditions. However, it underestimates at night and in shadowed locations. One grass surface used to develop the parameterisation, with very different characteristics compared to an evaluation grass site, caused T-mrt to be underestimated. The implications of using high temporal resolution (e.g. 15 minutes) meteorological forcing data under partly cloudy conditions are demonstrated even for fairly proximal sites.
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| 50150. |
- Lindberg, Fredrik, 1974, et al.
(author)
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Mapping areas of potential slope failures in cohesive soils using a shadow-casting algorithm – A case study from SW Sweden
- 2011
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In: Computers and Geotechnics. - : Elsevier BV. - 0266-352X. ; 38, s. 791-799
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Journal article (peer-reviewed)abstract
- When performing landslide susceptibility mapping of rotational slides in fine grained soils, slope algorithms found in common GIS software have two major shortcomings. Firstly, these types of terrain algorithms only consider the slope angle at the surface. Secondly, the algorithm is local by its design i.e. it only considers neighbouring pixels. Due to the behaviour of a retrogressive rotational landslide, it would be more preferable to consider slope information as a predetermined cross-section angle from the base of the slope. This paper presents a new method using shadow casting algorithms for preliminary landslide susceptibility mapping in cohesive soils. A case study from western Sweden is also presented.
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