| 41. |
- Aboagye, Emmanuel, et al.
(författare)
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Manual therapy versus advice to stay active for nonspecific back and/or neck pain : A cost-effectiveness analysis
- 2022
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Ingår i: Chiropractic and Manual Therapies. - : Springer Science and Business Media LLC. - 2045-709X. ; 30:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Low back and neck pain are the most common musculoskeletal disorders worldwide, and imply suffering and substantial societal costs, hence effective interventions are crucial. The aim of this study was to evaluate the cost-effectiveness of manual therapy compared with advice to stay active for working age persons with nonspecific back and/or neck pain.METHODS: The two interventions were: a maximum of 6 manual therapy sessions within 6 weeks, including spinal manipulation/mobilization, massage and stretching, performed by a naprapath (index group), respectively information from a physician on the importance to stay active and on how to cope with pain, according to evidence-based advice, at 2 occasions within 3 weeks (control group). A cost-effectiveness analysis with a societal perspective was performed alongside a randomized controlled trial including 409 persons followed for one year, in 2005. The outcomes were health-related Quality of Life (QoL) encoded from the SF-36 and pain intensity. Direct and indirect costs were calculated based on intervention and medication costs and sickness absence data. An incremental cost per health related QoL was calculated, and sensitivity analyses were performed.RESULTS: The difference in QoL gains was 0.007 (95% CI - 0.010 to 0.023) and the mean improvement in pain intensity was 0.6 (95% CI 0.068-1.065) in favor of manual therapy after one year. Concerning the QoL outcome, the differences in mean cost per person was estimated at - 437 EUR (95% CI - 1302 to 371) and for the pain outcome the difference was - 635 EUR (95% CI - 1587 to 246) in favor of manual therapy. The results indicate that manual therapy achieves better outcomes at lower costs compared with advice to stay active. The sensitivity analyses were consistent with the main results.CONCLUSIONS: Our results indicate that manual therapy for nonspecific back and/or neck pain is slightly less costly and more beneficial than advice to stay active for this sample of working age persons. Since manual therapy treatment is at least as cost-effective as evidence-based advice from a physician, it may be recommended for neck and low back pain. Further health economic studies that may confirm those findings are warranted. Trial registration Current Controlled Trials ISRCTN56954776. Retrospectively registered 12 September 2006, http://www.isrctn.com/ISRCTN56954776 .
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| 42. |
- Aboagye, Emmanuel, et al.
(författare)
-
What is Number of Days in Number of Times? : Associations Between, and Responsiveness of, Two Sickness Presenteeism Measures
- 2020
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Ingår i: Journal of Occupational and Environmental Medicine. - : Wolters Kluwer. - 1076-2752 .- 1536-5948. ; 62:5, s. e180-e185
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To examine the associations between sickness presenteeism (SP) reported as number of days with SP reported as number of times and to evaluate their responsiveness.Methods: The study population (n = 454) consisted of employed individuals, at risk of long-term sickness absence. Correlation analyses were performed to examine associations between the two SP measures and external constructs such as work performance, general health, and registered sick leave. Both SP constructs were measured several times to examine responsiveness.Results: The SP measures are moderately correlated. They moderately correlated with work performance and health status measures. SP reported as number of times seems to be more sensitive than number of days in detecting changes after rehabilitation.Conclusions: Numerical or categorical constructs are valid sources of data on SP. However, categorized SP seems to be more responsive.
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| 43. |
- Aboul-Ata, Aboul-Ata E, et al.
(författare)
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Plant-based vaccines: novel and low-cost possible route for mediterranean innovative vaccination strategies.
- 2014
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Ingår i: Advances in Virus Research. - : Elsevier. - 1557-8399. ; 89, s. 1-37, s. 1-37
-
Forskningsöversikt (refereegranskat)abstract
- A plant bioreactor has enormous capability as a system that supports many biological activities, that is, production of plant bodies, virus-like particles (VLPs), and vaccines. Foreign gene expression is an efficient mechanism for getting protein vaccines against different human viral and nonviral diseases. Plants make it easy to deal with safe, inexpensive, and provide trouble-free storage. The broad spectrum of safe gene promoters is being used to avoid risk assessments. Engineered virus-based vectors have no side effect. The process can be manipulated as follows: (a) retrieve and select gene encoding, use an antigenic protein from GenBank and/or from a viral-genome sequence, (b) design and construct hybrid-virus vectors (viral vector with a gene of interest) eventually flanked by plant-specific genetic regulatory elements for constitutive expression for obtaining chimeric virus, (c) gene transformation and/or transfection, for transient expression, into a plant-host model, that is, tobacco, to get protocols processed positively, and then moving into edible host plants, (d) confirmation of protein expression by bioassay, PCR-associated tests (RT-PCR), Northern and Western blotting analysis, and serological assay (ELISA), (e) expression for adjuvant recombinant protein seeking better antigenicity, (f) extraction and purification of expressed protein for identification and dosing, (g) antigenicity capability evaluated using parental or oral delivery in animal models (mice and/or rabbit immunization), and (h) growing of construct-treated edible crops in protective green houses. Some successful cases of heterologous gene-expressed protein, as edible vaccine, are being discussed, that is, hepatitis C virus (HCV). R9 mimotope, also named hypervariable region 1 (HVR1), was derived from the HVR1 of HCV. It was used as a potential neutralizing epitope of HCV. The mimotope was expressed using cucumber mosaic virus coat protein (CP), alfalfa mosaic virus CP P3/RNA3, and tobacco mosaic virus (TMV) CP-tobacco mild green mosaic virus (TMGMV) CP as expression vectors into tobacco plants. Expressed recombinant protein has not only been confirmed as a therapeutic but also as a diagnostic tool. Herpes simplex virus 2 (HSV-2), HSV-2 gD, and HSV-2 VP16 subunits were transfected into tobacco plants, using TMV CP-TMGMV CP expression vectors.
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| 44. |
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| 45. |
- Abraha, Desalegn, et al.
(författare)
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Relationships and Networks in the Processes of Establishment of Firms in Transitional Economies : The case of Scandinavian firms in Eastern and Central Europe
- 2006
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Rapport (populärvet., debatt m.m.)abstract
- Focus on the particular entry mode a firm uses to enter a new market, rather than the process of establishment dominates in extant literature. To fill this void, we apply an establishment process model developed from the network approach to illuminate the web of relationship forms embedded in the establishment process of two Scandinavian firms as they attempt to establish themselves in transition economies. In one case, the results show that Statoil’s process of establishment in Estonia was less time- and resource-consuming because the firm drew support from significant actors in their network of exchange relationships. In the second case, a lack of home and host country support for Scania in Croatia resulted in an arduous and costly process and less stable position in the market, with the firm’s position changing several times as different problems cropped up. In light of the findings from the two cases, theoretical and practical implications for managing the establishment process are discussed.
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| 46. |
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| 47. |
- Abraha, Desalegn, et al.
(författare)
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Transformation of Strategic Alliances in Emerging Markets : Volume I
- 2021. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- There is much research into strategic business alliances in emerging markets, but none focuses on this form of collaboration within Europe’s emerging economies. This is a critical absence, as the European transition region is not only different from other European and Western regions but also from other regions with developing economies. Partners in the European transition region have unique cultural and social backgrounds, and consequently, unique ways of doing business. Transformations of Strategic Alliances in Emerging Markets focuses on this important gap. This book, the first of a two-volume set, makes a unique contribution to emerging market research by investigating the transformation of alliances in Eastern and central Europe over the past forty years. It provides a conceptual framework to describe and analyse the formation, development and functional mechanisms of strategic alliances in the European transition region, ultimately offering an in-depth overview of the challenges and opportunities around strategic alliance formation in emerging European markets. Transformations of Strategic Alliances in Emerging Markets, Volume I, is a must-read for academics and postgraduate students of development economics and business administration.
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| 48. |
- Abraha Gebrekidan, Desalegn, et al.
(författare)
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From industrial networks to strategic alliances or vice-versa
- 2009
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Ingår i: International Journal of Business and Emerging Markets. - : InderScience Publishers. - 1753-6219 .- 1753-6227. ; 1:4, s. 361-386
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this paper is: to highlight the impact of industrial networks on strategic alliances; to determine if alliances help firms to build up new or strengthen existing networks; to find out whether alliances succeed or precede networks. Our findings show that well-developed networks have a positive impact on how alliances function and the results that they can achieve. The other finding is that alliances defend and strengthen networks, and also enable firms to build new ones or penetrate those of their alliance partner(s). The final conclusion is that it is difficult to determine if alliances succeed or precede networks.
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| 49. |
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| 50. |
- Abrahamsen, Håkon B, et al.
(författare)
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Simulation-based training and assessment of non-technical skills in the Norwegian Helicopter Emergency Medical Services : a cross-sectional survey
- 2015
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Ingår i: Emergency Medicine Journal. - : BMJ. - 1472-0205 .- 1472-0213. ; 32:8, s. 647-653
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Human error and deficient non-technical skills (NTSs) among providers of ALS in helicopter emergency medical services (HEMS) is a threat to patient and operational safety. Skills can be improved through simulation-based training and assessment. Objective: To document the current level of simulation-based training and assessment of seven generic NTSs in crew members in the Norwegian HEMS. Methods: A cross-sectional survey, either electronic or paper-based, of all 207 physicians, HEMS crew members (HCMs) and pilots working in the civilian Norwegian HEMS (11 bases), between 8 May and 25 July 2012. Results: The response rate was 82% (n=193). A large proportion of each of the professional groups lacked simulation-based training and assessment of their NTSs. Compared with pilots and HCMs, physicians undergo statistically significantly less frequent simulation-based training and assessment of their NTSs. Fifty out of 82 (61%) physicians were on call for more than 72 consecutive hours on a regular basis. Of these, 79% did not have any training in coping with fatigue. In contrast, 72 out of 73 (99%) pilots and HCMs were on call for more than 3 days in a row. Of these, 54% did not have any training in coping with fatigue. Conclusions: Our study indicates a lack of simulation-based training and assessment. Pilots and HCMs train and are assessed more frequently than physicians. All professional groups are on call for extended hours, but receive limited training in how to cope with fatigue.
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