| 21. |
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| 22. |
- Abolhalaj, Milad, et al.
(author)
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Transcriptional profiling demonstrates altered characteristics of CD8 + cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia
- 2022
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 11:15, s. 3023-3032
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Journal article (peer-reviewed)abstract
- Background: Acute myeloid leukemia (AML) patients have limited effect from T-cell-based therapies, such as PD-1 and CTLA-4 blockade. However, recent data indicate that AML patients with TP53 mutation have higher immune infiltration and other immunomodulatory therapies could thus potentially be effective. Here, we performed the transcriptional analysis of distinct T-cell subpopulations from TP53-mutated AML to identify gene expression signatures suggestive of altered functional properties.Methods: CD8+ cytotoxic T lymphocytes (CTLs), conventional helper T cells (Th), and regulatory T cells (Tregs) were sorted from peripheral blood of AML patients with TP53 mutation (n = 5) and healthy donors (n = 3), using FACS, and the different subpopulations were subsequently subjected to RNA-sequencing. Differentially expressed genes were identified and gene set enrichment analysis (GSEA) was performed to outline altered pathways and exhaustion status. Also, expression levels for a set of genes encoding established and emerging immuno-oncological targets were defined.Results: The results showed altered transcriptional profiles for each of the T-cell subpopulations from TP53-mutated AML as compared to control subjects. IFN-α and IFN-γ signaling were stronger in TP53-mutated AML for both CTLs and Tregs. Furthermore, in TP53-mutated AML as compared to healthy controls, Tregs showed gene expression signatures suggestive of metabolic adaptation to their environment, whereas CTLs exhibited features of exhaustion/dysfunction with a stronger expression of TIM3 as well as enrichment of a gene set related to exhaustion.Conclusions: The results provide insights on mechanisms underlying the inadequate immune response to leukemic cells in TP53-mutated AML and open up for further exploration toward novel treatment regimens for these patients.
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| 23. |
- Abrahamsson, Christian
(author)
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Drottningens fråga
- 2010
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In: Ordfront Magasin. - 0284-981X.
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Journal article (pop. science, debate, etc.)
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| 24. |
- Abrahamsson, Cristian
(author)
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Elevengagemang ur ett NO-lärarperspektiv : Hur lärare uppfattar elevers engagemang och dess betydelse för lärarrollen och undervisningen
- 2019
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Licentiate thesis (other academic/artistic)abstract
- AbstractThis essay focuses on teachers' perspective on student engagement and aims to highlight the connection between student engagement, teaching and content matter. It investigates how teachers interpret the concept of student engagement and what consequences their interpretation have for themselves, their teaching and their students. It also examines how teachers perceive the relationship between student engagement and the content of science teaching. The study is based on a theoretical view on engagement as a context-dependent, multi-dimensional concept that includes other concepts such as interest and motivation. Engagement is a concept often used when describing a desirable quality of school students. In research, the concept has been linked to students' outcome and lack of engagment as a precursor for drop-out from school behaviour. Many studies about engagement focus on how the concept is to be defined and measured and how engagement is influenced by its context, often described with other concepts such as attitude, interest and motivation. These studies often have a student-oriented perspective with questionnaires or self-assessments.Two methods for data collecting has been used. First, a three-stage Delphi survey distributed to 39 Swedish expert science teachers and second, four focus group interviews with a total of 21 science teachers teaching in Swedish upper primary school. The results show that teachers in the studies had no problem to use the concept of engagement even though they did not have a clear definition of what it stands for. They link engagement to motivation and interest and often interpret students’ feelings or behaviours as engagement, whereas evidence of cognitive strategies often go unnoticed. The teachers emphasize that their teaching in terms of strategies, methods and relations to studens is of great importance to students' engagement rather than content matter, itself. The major conclusions concern the relation between teaching and student engagement. Teachers can create engagement by using interesting aspects of the content or by linking it to students' own experiences. They see students' engagement as a confirmation of their own ability and the quality of their work. Their interpretation of the students' responses will then influence the form and content of teaching as student engagement is considered important. The results imply that engagement has a role to play as a concept teachers can use when they want to discuss science teaching and students' learning. This requires that teachers gain a deeper understanding of all dimensions of student engagement in view of the major influence student engagement has on the teacher and thereby the teaching. Then teachers’ knowledge about how to create engagement in science can be used as a means of increasing students’ learning, not for engagement as a goal for the teaching itself.
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| 25. |
- Abrahamsson, Cristian, et al.
(author)
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En Delfistudie om lärares uppfattning av elevengagemang i NO-undervisningen
- 2019
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In: NorDiNa. - Oslo : Naturfagsenteret / Norwegian Centre for Science Education. - 1504-4556 .- 1894-1257. ; 15:2, s. 128-144
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Journal article (peer-reviewed)abstract
- What happens in a science classroom where students are engaged and how do teachers observe and interpret student engagement? This article highlights teachers’ perspective on students’ engagement in science education and to what extent it is connected to the scientific content. This approach complements earlier research which focuses mostly on students’ attitude towards science education and their interest in various topics in science.The findings are based on a three-stage Delphi survey distributed to 39 expert science teachers. The results shows science education with a range of different perspectives and that most teachers do not perceive any direct connection between specific science topics and the students’ engagement. The survey also shows that teachers to a high level interpret students’ emotional expressions and academic behavior as engagement rather than their cognitive behavior.
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| 26. |
- Abrahamsson, Jan, et al.
(author)
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Sopact - en katalysator för samhällsnytta
- 2020
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In: 1666. 1999. 2000. 2020. Campus Helsingborg 20 år.. - 9789151970912 ; , s. 327-333
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Book chapter (pop. science, debate, etc.)
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| 27. |
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| 28. |
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| 29. |
- Abrahamsson Lindeblad, Peter, et al.
(author)
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Handledning för mätning och utvärdering av resfria möten
- 2014
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Reports (other academic/artistic)abstract
- Det resfria mötet – vårt sätt att arbeta och träffas utan att vara på samma plats fysiskt – blir allt vanligare. Men vad blir effekterna och hur mäter vi dessa? Med hjälp av verktyg som telefonkonferenser, videokonferenser och datorstödda mötesverktyg sköter vi en allt större del av vår dagliga verksamhet. Organisationer inför och använder resfria mötesverktyg med en förhoppning att de ska medföra en mängd positiva effekter: besparingar i tid, resande och kostnader, minskad stress bland medarbetarna, ökad produktivitet, och i förlängningen även en minskad belastning på miljön. För att kunna följa upp om de önskade effekterna faktiskt uppnås har denna handledning tagits fram. Handledningen ger förslag på hur användningen av resfria möten och effekterna därav mäts, hur man kan tolka resultatet och förslag på vad man kan göra för att förbättra resultatet.
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| 30. |
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