SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:uu ;conttype:(refereed)"

Sökning: LAR1:uu > Refereegranskat

  • Resultat 116561-116570 av 163223
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
116561.
  •  
116562.
  •  
116563.
  • Pirinen, Riku, et al. (författare)
  • The Outcome after Endovascular and Open Repair of Abdominal Aortic Aneurysms-A Binational Study Conducted between 1998 and 2017
  • 2024
  • Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 13:15
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: We aimed to analyse patient outcomes following open (OAR) or endovascular repair (EVAR) of an abdominal aortic aneurysm (AAA) in Finland and Sweden from 1998 to 2017. Both intact and ruptured AAAs (rAAAs) were included in the analysis.Methods: Patient-level data from national registries in Finland and Sweden were analysed, pairing operations for intact and ruptured AAA repair with mortality data (date of death). All-cause mortality was the primary endpoint. Anonymized patient data from both countries were pooled, comprising a total of 32,324 operations. Ruptured and intact AAAs were considered separately. In total, EVAR was performed on 9619 intact AAAs and 1470 rAAAs, while OAR was performed on 13,241 intact AAAs and 7994 rAAAs. The patient's age, sex and the date of operation were obtained as demographic information. Cox regression and Kaplan-Meier analyses were used to evaluate long-term (10-year) survival after the treatment of AAA or rAAA with either modality. Kaplan-Meier analysis was performed in three different age groups (<65 years, 65-79 years and >= 80 years).Results: Considering all age groups together, the 1-, 3- and 10-year Kaplan-Meier survival rates after EVAR were 93.4%, 80.5% and 35.3%, respectively, for intact AAA repair and 67.2%, 55.9% and 22.2%, respectively, for rAAA repair. For OAR of intact AAAs, the 1-, 3- and 10-year Kaplan-Meier survival rates were 92.1%, 84.8% and 48.7%, respectively. The respective rates for OAR of rAAAs were 55.4%, 49.3% and 24.6%. In a Cox regression analysis, a more recent year of operation was associated with improved survival, and older age affected survival negatively for both intact and ruptured AAA repair. If patients survived the first 90 days after the operation, the survival after intact AAA repair was 13.5 years for those <65 years (general population: 18.0 years), and 7.3 years for those >= 80 years (general population: 7.9 years). After rAAA repair, the mean survival was 13.1 years for patients <65 years and 5.5 years for patients >= 80 years, respectively.Conclusions: The long-term survival of patients undergoing intact AAA treatment at the age of 80 or older is close to that of the general population, provided they survive the operation. Conversely, for patients younger than 65, the long-term survival is markedly worse. The long-term survival of AAA patients has improved over time. Open surgery is still a safe and effective option for young patients undergoing intact AAA repair. Our results support the ESVS guidelines recommendation of EVAR being the first-line treatment for patients with rAAA.
  •  
116564.
  •  
116565.
  •  
116566.
  • Pirkola, Laura, et al. (författare)
  • Fecal microbiota composition affects in vitro fermentation of rye, oat, and wheat bread
  • 2023
  • Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Fermentation of dietary fiber by gut microbes produces short-chain fatty acids (SCFA), but fermentation outcomes are affected by dietary fiber source and microbiota composition. The aim of this study was to investigate the effect of two different fecal microbial compositions on in vitro fermentation of a standardized amount of oat, rye, and wheat breads. Two human fecal donors with different microbial community composition were recruited. Bread samples were digested enzymatically. An in vitro fermentation model was used to study SCFA production, dietary fiber degradation, pH, and changes in microbiota. Feces from donor I had high relative abundance of Bacteroides and Escherichia/Shigella, whereas feces from donor II were high in Prevotella and Subdoligranulum. Shifts in microbiota composition were observed during fermentation. SCFA levels were low in the samples with fecal microbiota from donor I after 8 h of fermentation, but after 24 h acetate and propionate levels were similar in the samples from the different donors. Butyrate levels were higher in the fermentation samples from donor II, especially with rye substrate, where high abundance of Subdoligranulum was observed. Dietary fiber degradation was also higher in the fermentation samples from donor II. In conclusion, fermentation capacity and substrate utilization differed between the two different microbiota compositions.
  •  
116567.
  • Pirmohamed, Munir, et al. (författare)
  • A Randomized Trial of Genotype-Guided Dosing of Warfarin
  • 2013
  • Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 369:24, s. 2294-2303
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The level of anticoagulation in response to a fixed-dose regimen of warfarin is difficult to predict during the initiation of therapy. We prospectively compared the effect of genotype-guided dosing with that of standard dosing on anticoagulation control in patients starting warfarin therapy.Methods: We conducted a multicenter, randomized, controlled trial involving patients with atrial fibrillation or venous thromboembolism. Genotyping for CYP2C9*2, CYP2C9*3, and VKORC1 (-1639GA) was performed with the use of a point-of-care test. For patients assigned to the genotype-guided group, warfarin doses were prescribed according to pharmacogenetic-based algorithms for the first 5 days. Patients in the control (standard dosing) group received a 3-day loading-dose regimen. After the initiation period, the treatment of all patients was managed according to routine clinical practice. The primary outcome measure was the percentage of time in the therapeutic range of 2.0 to 3.0 for the international normalized ratio (INR) during the first 12 weeks after warfarin initiation.Results: A total of 455 patients were recruited, with 227 randomly assigned to the genotype-guided group and 228 assigned to the control group. The mean percentage of time in the therapeutic range was 67.4% in the genotype-guided group as compared with 60.3% in the control group (adjusted difference, 7.0 percentage points; 95% confidence interval, 3.3 to 10.6; P<0.001). There were significantly fewer incidences of excessive anticoagulation (INR 4.0) in the genotype-guided group. The median time to reach a therapeutic INR was 21 days in the genotype-guided group as compared with 29 days in the control group (P<0.001).Conclusions: Pharmacogenetic-based dosing was associated with a higher percentage of time in the therapeutic INR range than was standard dosing during the initiation of warfarin therapy. 
  •  
116568.
  •  
116569.
  • Pirmohamed, Munir, et al. (författare)
  • Oral anticoagulation : a critique of recent advances and controversies
  • 2015
  • Ingår i: TIPS - Trends in Pharmacological Sciences. - : Elsevier BV. - 0165-6147 .- 1873-3735. ; 36:3, s. 153-163
  • Forskningsöversikt (refereegranskat)abstract
    • There have recently been significant advances in the field of oral anticoagulation, but these have also led to many controversies. Warfarin is still the commonest drug used for clotting disorders but its use is complicated owing to wide inter-individual variability in dose requirement and its narrow therapeutic index. Warfarin dose requirement can be influenced by both genetic and environmental factors. Two recent randomized controlled trials (RCTs) came to different conclusion regarding the utility of genotype-guided dosing; we critically explore the reasons for the differences. The new generation of oral anticoagulants have been demonstrated to be as efficacious as warfarin, but further work is needed to evaluate their safety in real clinical settings.
  •  
116570.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 116561-116570 av 163223
Typ av publikation
tidskriftsartikel (131538)
konferensbidrag (15224)
bokkapitel (8805)
forskningsöversikt (4031)
bok (1307)
samlingsverk (redaktörskap) (992)
visa fler...
recension (661)
rapport (273)
proceedings (redaktörskap) (259)
annan publikation (125)
konstnärligt arbete (36)
visa färre...
Typ av innehåll
refereegranskat  (163223)Ta bort avgränsningen
Författare/redaktör
Ekelöf, Tord (1140)
Brenner, Richard (1117)
Ellert, Mattias (1098)
Strandberg, Jonas (1065)
Zwalinski, L. (1028)
Bohm, Christian (906)
visa fler...
Larsson, Anders (904)
Abbott, B. (806)
Aad, G (767)
Kupsc, Andrzej (757)
Silverstein, Samuel ... (756)
Lund-Jensen, Bengt (714)
Moa, Torbjörn (706)
Hellman, Sten (678)
Wolke, Magnus (666)
Zhu, J. (643)
Peters, K. (632)
Clement, Christophe (626)
Sjölin, Jörgen (621)
Janson, Christer (618)
Zhou, B. (614)
Meyer, J. (613)
Liu, Y. (612)
Fox, H. (611)
Evans, H. (608)
Gutierrez, P. (608)
Brandt, A. (607)
Brock, R. (607)
Burdin, S. (607)
Kupco, A. (607)
Pleier, M. -A. (607)
Quadt, A. (607)
Sawyer, L. (607)
Stark, J. (607)
Borissov, G. (606)
Cooke, M. (606)
Kehoe, R. (606)
Lokajicek, M. (606)
Qian, J. (606)
Schwienhorst, R. (606)
Snyder, S. (606)
Watts, G. (606)
Khanov, A. (605)
Severini, H. (605)
Shabalina, E. (605)
Rizatdinova, F. (604)
Strauss, M. (604)
Fiedler, F. (603)
Hohlfeld, M. (603)
Tsybychev, D. (603)
visa färre...
Lärosäte
Uppsala universitet (163223)
Karolinska Institutet (16765)
Lunds universitet (6608)
Kungliga Tekniska Högskolan (6120)
Stockholms universitet (5710)
Umeå universitet (4713)
visa fler...
Göteborgs universitet (4570)
Linköpings universitet (4125)
Örebro universitet (2540)
Sveriges Lantbruksuniversitet (2191)
Högskolan Dalarna (1291)
Linnéuniversitetet (1126)
Mälardalens universitet (1109)
Chalmers tekniska högskola (1006)
Högskolan i Gävle (949)
Karlstads universitet (668)
Mittuniversitetet (662)
Södertörns högskola (638)
Luleå tekniska universitet (483)
RISE (442)
Jönköping University (393)
Malmö universitet (375)
Högskolan i Skövde (276)
Marie Cederschiöld högskola (268)
Naturhistoriska riksmuseet (199)
Högskolan i Borås (158)
Försvarshögskolan (151)
Handelshögskolan i Stockholm (148)
Sophiahemmet Högskola (136)
Högskolan i Halmstad (127)
Gymnastik- och idrottshögskolan (122)
Röda Korsets Högskola (108)
Högskolan Kristianstad (81)
Nordiska Afrikainstitutet (76)
Enskilda Högskolan Stockholm (56)
Högskolan Väst (49)
Institutet för språk och folkminnen (43)
Blekinge Tekniska Högskola (34)
VTI - Statens väg- och transportforskningsinstitut (26)
Kungl. Musikhögskolan (15)
Riksantikvarieämbetet (12)
IVL Svenska Miljöinstitutet (9)
Konstfack (5)
Naturvårdsverket (2)
Stockholms konstnärliga högskola (1)
visa färre...
Språk
Engelska (151825)
Svenska (7061)
Odefinierat språk (2201)
Tyska (548)
Franska (435)
Spanska (190)
visa fler...
Ryska (154)
Danska (107)
Nederländska (100)
Italienska (90)
Norska (89)
Polska (69)
Finska (50)
Estniska (47)
Turkiska (43)
Isländska (32)
Kinesiska (29)
Portugisiska (26)
Japanska (20)
Ungerska (16)
Esperanto (15)
Kroatiska (10)
Koreanska (10)
Nygrekiska (7)
Bulgariska (5)
Slovakiska (5)
Iriska (5)
Rumänska (4)
Serbiska (4)
Ukrainska (4)
Nynorsk (4)
Persiska (3)
Latin (2)
Tjeckiska (2)
Vietnamesiska (2)
Baluchi (2)
Grekiska, klassisk (1)
Katalanska (1)
Hindi (1)
Swahili (1)
Indonesiska (1)
Bokmål (1)
Frisiska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Naturvetenskap (48149)
Medicin och hälsovetenskap (36675)
Samhällsvetenskap (18819)
Humaniora (12399)
Teknik (9433)
Lantbruksvetenskap (1506)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy