| 21. |
- Adolfsson, Jan, et al.
(författare)
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Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 41:6, s. 456-477
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment. MATERIAL AND METHODS: Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR). This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis. RESULTS: In total, 72,028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR). During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of > 100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score <6. Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed. Treatment with curative intent increased dramatically and treatment patterns varied according to geographical region. In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged > or =75 years than in those aged <75 years. Also, the pattern of endocrine treatment varied in different parts of Sweden. CONCLUSIONS: All changes in the register seen over time are consistent with increased diagnostic activity, especially PSA testing, resulting in an increased number of cases with early disease, predominantly tumors in category T1c. The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden. The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer.
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| 22. |
- Adranno, Brando, et al.
(författare)
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The 8-hydroxyquinolinium cation as a lead structure for efficient color-tunable ionic small molecule emitting materials
- 2023
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Ingår i: Advanced Photonics Research. - : John Wiley & Sons. - 2699-9293. ; 4:3
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Tidskriftsartikel (refereegranskat)abstract
- Albeit tris(8-hydroxyquinolinato) aluminum (Alq3) and its derivatives are prominent emitter materials for organic lighting devices, and the optical transitions occur among ligand-centered states, the use of metal-free 8-hydroxyquinoline is impractical as it suffers from strong nonradiative quenching, mainly through fast proton transfer. Herein, it is shown that the problem of rapid proton exchange and vibration quenching of light emission can be overcome not only by complexation, but also by organization of the 8-hydroxyquinolinium cations into a solid rigid network with appropriate counter-anions (here bis(trifluoromethanesulfonyl)imide). The resulting structure is stiffened by secondary bonding interactions such as pi-stacking and hydrogen bonds, which efficiently block rapid proton transfer quenching and reduce vibrational deactivation. Additionally, the optical properties are tuned through methyl substitution from deep blue (455 nm) to blue-green (488 nm). Time-dependent density functional theory (TDFT) calculations reveal the emission to occur from which an unexpectedly long-lived S-1 level, unusual for organic fluorophores. All compounds show comparable, even superior photoluminescence compared to Alq3 and related materials, both as solids and thin films with quantum yields (QYs) up to 40-50%. In addition, all compounds show appreciable thermal stability with decomposition temperatures above 310 °C.
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| 23. |
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| 24. |
- Agmon-Levin, Nancy, et al.
(författare)
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International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies
- 2014
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 73:1, s. 17-23
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Tidskriftsartikel (refereegranskat)abstract
- Anti-nuclear antibodies (ANA) are fundamental for the diagnosis of autoimmune diseases, and have been determined by indirect immunofluorescence assay (IIFA) for decades. As the demand for ANA testing increased, alternative techniques were developed challenging the classic IIFA. These alternative platforms differ in their antigen profiles, sensitivity and specificity, raising uncertainties regarding standardisation and interpretation of incongruent results. Therefore, an international group of experts has created recommendations for ANA testing by different methods. Two groups of experts participated in this initiative. The European autoimmunity standardization initiative representing 15 European countries and the International Union of Immunologic Societies/World Health Organization/Arthritis Foundation/Centers for Disease Control and Prevention autoantibody standardising committee. A three-step process followed by a Delphi exercise with closed voting was applied. Twenty-five recommendations for determining ANA (1-13), anti-double stranded DNA antibodies (14-18), specific antibodies (19-23) and validation of methods (24-25) were created. Significant differences between experts were observed regarding recommendations 24-25 (p<0.03). Here, we formulated recommendations for the assessment and interpretation of ANA and associated antibodies. Notably, the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining, were emphasised, while the need to incorporate alternative automated methods was acknowledged. Various approaches to overcome discrepancies between methods were suggested of which an improved bench-to-bedside communication is of the utmost importance. These recommendations are based on current knowledge and can enable harmonisation of local algorithms for testing and evaluation of ANA and related autoantibodies. Last but not least, new more appropriate terminologies have been suggested.
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| 25. |
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| 26. |
- Agnidakis, Paul, 1974-
(författare)
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Ethnology : Theories and methods
- 2018. - 1
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Ingår i: The International Encyclopedia of Anthropology. - Hoboken, NJ : John Wiley & Sons. - 9780470657225 - 9781118924396 ; , s. 1-13
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Bokkapitel (refereegranskat)abstract
- Ethnology is a disciplinary field that is more or less interwoven with anthropology. Its main focus is the analysis of various cultures and cultural expressions, usually within a national context. In practice, ethnologists favor an approach toward culture from the individual perspective, with a key interest in how single ordinary individuals, seen as active cultural beings, think and act in their everyday lives. This implies that they are both shaped by and contributors to the shaping of cultures in their everyday lives. However, within ethnology, culture viewed as a bidirectional phenomenon is not merely regarded as an individual process. Rather, it is regarded as something that occurs in collective social contexts. When analyzing culture, ethnologists usually employ a combined focus on its ideational and folkloric aspects as well as aspects of materiality, locality, and identity. Ethnology's general methodological approaches comprise ethnographic fieldwork as well as studies of artifacts and sociocultural structures.
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| 27. |
- Agnidakis, Paul, 1974-
(författare)
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Etnologi : Kontinuitet och anpassning av ett kulturvetenskapligt ämne
- 2018
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Ingår i: RIG. - Uppsala : Kungl. Gustav Adolfskademien för svensk folkkultur. - 0035-5267 .- 2002-3863. ; 101:1, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- Ethnology. The Adaptability and Continuity of a DisciplineThis article discusses the development throughtime and space of ethnology as a multifaceted disciplinaryfield. The objective of the article,however, is to challenge possible pre-assumptionsof ethnology as an incoherent i.e. variable and inconstant discipline, due to national limitations andtheoretical and methodological responsiveness, byproposing some core aspects regarding focalpoints,perspectives and methods that may beconsidered as prominent and unifying amongstethnologists both in Sweden and abroad. The articleargues for a general and continuing disciplinarianfocus on culture as a pluralistic, complexand individual-based phenomenon, as well as fundamentalinterest in the functions, social structures,constructions and experiences of cultures.Furthermore, the article describes how both earlierand later generations of ethnologists in generalhave chosen to study culture based on a selectionof recurring perspectives that comprise boththe intangible and tangible aspects of culture, aswell as the spatial and social contexts in whichcultures are formed and maintained. Finally, thearticle highlights how different types of ethnologicaldata are collected and analyzed via a combinationof constantly developed methods of culturalanalysis, though rooted in a disciplinarian tradition. In conclusion, despite a continuous progressionand adjustments within ethnology in regardto perspectives and methods over time and space,this has more often resulted in additions ratherthan replacements. For this reason, it seems relevantto define ethnology as a coherent discipline,designated by both adaptation and continuity.
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| 28. |
- Agnidakis, Paul, 1974-
(författare)
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Folkfest kring lokalhistoriska betydelser : Kulturarvsbetonade festivaler för främjandet av lokal identitet på postindustriella mindre orter
- 2018
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Ingår i: Tidsskrift for kulturforskning. - Oslo : Novus Forlag. - 1502-7473 .- 2387-6727. ; 17:2, s. 45-65
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Tidskriftsartikel (refereegranskat)abstract
- Celebrating local history – Cultural heritage festivals in post-industrial small towns as prerequisites for local identificationMany minor post-industrial communities in Sweden, such as Surahammar and Timrå, struggle with financial difficulties and socio-cultural challenges due to the industrial decline and increased dependency on immigration from neighboring cities. In the light of this, arranging annual local festivals with a focus on cultural heritage can be seen as an opportunity to strengthen local identity as well as its inhabitant’s coexistences and sense of belonging. This article aims to analyze two local festivals, viewed as platforms for the production, communication and experiences of local cultural heritage values. Empirically resting on data collection and analysis of mainly ethnographic fieldwork, comprising interviews and observations, the article argues that these post-industrial local festivals involves identificational negotiations in regard to both the ritualized communication and implementation of local cultural heritage values. In conclusion, these festivals confirms a clearly industrial linked local cultural heritage but at the same time challenges it through enlargements, sufficiently vigilant connected to a local past in order to allow for inclusive local identifications, regardless of e.g. spatial origins.
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| 29. |
- Agnidakis, Paul, 1974-, et al.
(författare)
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I riktning mot en normkreativ kulturmiljövård : Metodutveckling utifrån exemplet Statens fastighetsverk i Sverige
- 2018
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Ingår i: Kulturstudier. - København : Dansk Historisk Fællesråd. - 1904-5352. ; 9:1, s. 167-198
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Tidskriftsartikel (refereegranskat)abstract
- Utifrån tvärvetenskapliga perspektiv och metoder, hämtade från etnologin och kulturgeografin, och med en empirisk utgångspunkt i tre kulturmiljöer som förvaltas av Statens fastighetsverk (SFV) i Sverige, analyserar artikeln historiebruk i form av kulturarvsproduktion och föreslår ett applicerbart normkritiskt samt i förlängningen normkreativt angreppssätt för att möjliggöra alternativa, varierade och mer inkluderande historieskildringar kring kulturmiljöer. Genom att utveckla och integrera dessa synsätt och verktyg vill artikeln argumentera för att man får tillgång till nya berättelser om platsen; berättelser som går utöver den traditionella, „normala“ historien om staten, enskilda byggnaders materiella utformning och den sociokulturella och ekonomiska eliten. En långsiktig effekt blir att det möjliggör ökad mångfald och inkludering både i fråga om förmedling och representation av platser som komplexa rumsliga och sociokulturella helheter.
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| 30. |
- Agnidakis, Paul, 1974-
(författare)
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Ideologisering, manifestering och gemenskapande : kulturarvsproduktion som process i lokala industrisamhällen under omvandling
- 2019
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Ingår i: RIG. - Uppsala : Kungl. Gustav Adolfs Akademien för svensk folkkultur. - 0035-5267 .- 2002-3863. ; 102:2, s. 65-86
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Tidskriftsartikel (refereegranskat)abstract
- Ideologization, manifestation and community making - Processes of heritage production in two local communities in transitionAs the local industry has taken on an increasingly marginalized role in post-industrial small towns, like Surahammar and Timrå, in Central and Northern Sweden, an industrial past has emerged as the more valuable politically, economically but also socio-culturally, to nurture, preserve and identify with in these local industrial communities that undergo transition. This article aims to analyze local heritage production as a use and representation of history. Empirically resting on data collection and analysis of primary and secondary sources, comprising interviews, observations, archives and contextual literature, the article argues that local post-industrial heritage production may involve continuation as well as alterations of processes started in the past industrial society. Also, it comprises local adaptation as well as adjustments on heritage discourses. In conclusion, despite of local differences similarities may, as shown in Surahammar and Timrå, indeed occur in both design and content. This involves a pre-dominance of “non-professional” producers and including and excluding representations of places and people. Furthermore, local heritage provide combined political, economic and socio-cultural arenas of different ideologies as well as sites for creation of shared values and evoking emotions of belonging in diversified communities. In Surahammar and Timrå this has been done recurrently with the use of effective homogenization strategies within the field of heritage, i.e. by emphasizing sufficiently remote pasts to induce temporary but nevertheless efficient “classless and rootless” unity in pride of local place and values.
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