| 61. |
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| 62. |
- Hrynczenko, Iwona, et al.
(författare)
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Shadow dance : Installation and discussion on proposed solutions for embodied games through cross-disciplinary workshops within an educational context
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper argues the issue of embodiment and gesture in games, the aesthetics of movement from the phenomenological point of view, and suggests a framework proposal for DAMA, a Dance and Media Art Network interdisciplinary network project, which integrates students and teachers from art schools and universities within the European Nordic and Baltic regions. This argument is supported by documentation of Shadow Dance installation that presents an interactive tool for corporal expressions, based on real-time movement capture, an open source and visual programming environment (Pure Data), all integrated within a web environment. The aim of this installation is to propose a different perspective based on corporal movement’s aesthetics via subjective expressions. It is one of the action points for the game development process, during interdisciplinary workshops, proposing content based on traditions in dance and physical theatre and encouraging the notions of presence and creative use of whole body movements across digital space and especially within physical games.
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| 63. |
- Hållén, Elinor
(författare)
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Ignorance as method and methodology
- 2015
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Ingår i: Ignorance. - Stockholm : Axl Books. - 9789186883331 - 918688333X
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 64. |
- Højmark Søvsø, Mette, et al.
(författare)
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Pilgrimssouvenir
- 2016
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Ingår i: Skalk: Nyt om gammelt. - : Fonden Skalk. - 0560-1894. ; 1, s. 9-15
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 3D scans on a fragmented stone mould from medieval Ribe (in combination with a digital reconstruction of the casted metal object) show that it was used for the casting of spheric, hollow pilgrimssouvenirs, probably filled with soundmaking and scented materials, that were sold as during the 13th century.
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| 65. |
- Innocenti, Paolo, 1981-
(författare)
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Sexual Conflict and Gene Expression in Drosophila melanogaster
- 2011
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Sexual conflict is broadly defined as a conflict between the evolutionary interests of the two sexes. Depending on the genetic architecture of the traits involved, it can occur at the level of male-female interactions or take the form of selection acting to change the mean of a shared trait against the sign of its genetic correlation. The aim of my thesis was to use genome-wide expression profiles in the model organism Drosophila melanogaster to provide novel insights in the study of sexual conflict. First, we studied the female post-mating response to partition transcriptional changes associated with reproduction from male-induced effects, which are known to be harmful to females. We found substantial changes in expression of metabolic pathways associated with the activation of reproduction, while male-specific effects were dominated by the onset of an immune response. Changes in female response under different mating strategies was studied using experimental evolution: we found that monogamous females suffered decreased fecundity and their gene expression profiles suggested an overall weaker response to mating. To identify sexually antagonistic genes, we used hemiclonal lines and associated their sex-specific fitness with genome-wide transcript abundance. We confirmed the presence of a negative covariance for fitness and identified a group of candidate genes experiencing sexually antagonistic selection. We then focused on mitochondria, which can enable the accumulation of deleterious mutations with sex-specific effects due to their maternal inheritance, and found few effects on nuclear gene expression in females but major effects in males, predominantly in male-specific tissues. Finally, we used published data to compare intraspecific and interspecific genetic variation for a set of transcripts, to test whether speciation occurs along lines of maximum genetic variance. In conclusion, gene expression techniques can generate useful results in the study of sexual conflict, particularly in association with phenotypic data or when integrated with published datasets.
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| 66. |
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| 67. |
- Iordanoglou, Dimitrios, 1972-
(författare)
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Iliaden - en cover
- 2010
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Bok (övrigt vetenskapligt/konstnärligt)
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| 68. |
- Ishihara, Sachiko, et al.
(författare)
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The Critical Interference Podcast at CEMUS : Season 2 Episode 2
- 2022
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Annan publikation (ljud/tal) (populärvet., debatt m.m.)abstract
- Podcast interview by Daniel Mossberg, Outreach and Educational Coordinator at Centre for Environment and Development Studies (CEMUS), Uppsala University and Swedish University of Agricultural Scieinces, with the authors of the article "Student-led Education for a better world?" Reflections in conversation.Article abstract:This essay provokes who the “experts” are in discussions about education: why not the students who are most impacted by it? At the Centre for Environment and Development Studies (CEMUS), a joint centre between Uppsala University and Swedish University of Agricultural Sciences, students are hired as Course Coordinators (CCs) to develop and facilitate freestanding university courses. This paper is an outcome of a collaborative reflection exercise in the form of a written dialogue between students, CCs, and a guest lecturer of a CEMUS course “Reimagining Education”. This course focused on approaching learning and education on a meta-level where students and their experience become the subject of collaborative learning. By comparing the experience from this course with other courses at CEMUS and beyond, we discuss whether and how CEMUS challenges traditional pedagogies based on teacher-student hierarchies. Both the capacity for CCs to influence the content and pedagogical arrangements as well as the opportunities for non-CC students to take responsibility in steering class discussions were highlighted as empowering experiences. Wereflect upon how this and the use of arts-based pedagogies can lead to fostering community and how it motivates students to collectively engage in their personal learning experiences beyond curriculum goals.Read the article here: https://doi.org/10.23865/hu.v11.3006
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| 69. |
- Jaiteh, Mariama
(författare)
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New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
- 2020
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. GPCRs are important drug targets and are associated with diseases such as central nervous system (CNS) disorders, cardiovascular diseases, cancer, and diabetes. Currently, 34% of FDA-approved drugs mediate their effects via modulation of GPCRs. Research during the past decades has resulted in a deeper understanding of GPCR structure and function. Moreover, recent breakthroughs in structural biology allowed the determination of several atomic resolution GPCR structures. New paradigms in GPCR pharmacology have also emerged that can lead to improved drugs. Together, these advances provide new avenues for structure-based drug discovery. The work in this thesis focused on how the large amount of structural data gathered over the last decades can be used to model GPCR targets for which no experimental structures are available, and the use of structure-based virtual screening (SBVS) campaigns to identify ligands with tailored pharmacological properties. In paper I, we investigated how template selection affects the virtual screening performance of homology models of the D2 dopamine receptor (D2R) and serotonin 5-HT2A receptor (5-HT2AR). In papers II and III, SBVS methods were used to identify dual inhibitors of the A2A adenosine receptor (A2AAR) and an enzyme, which could be relevant for treatment of Parkinson’s Disease, and functionally selective D2R ligands from a focused library. Finally, we also investigated how structural information can complement computational and biophysical methods to model and characterize the A2AAR-D2R heterodimer (paper IV).
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| 70. |
- Kaewmaraya, Thanayut, 1984-
(författare)
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First-Principles Studies of Materials Properties : Pressure-Induced Phase Transitions & Functional Materials
- 2015
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents the first-principles studies of materials properties within the framework of the density functional theory (DFT). The thesis constitutes three main parts, i. e., pressure-induced phase transitions in solids, data-storage and clean-energy materials.The first part focuses on the predictions of crystal structures and the determinations of electronic properties of Xe-H2, FeB4 and Co3O4. Pressurizing Xe-H2 compound yields the formation of H-rich Xe(H2)8, which can exhibit a metallic feature at comparatively lower pressure than pure hydrogen. Hard superconducting FeB4 gets transformed into a novel transparent phase under pressure owing to the enhanced overlap of atomic cores. Spinel Co3O4 undergoes the phase transition from a cubic to a monoclinic because of the charge transfer between cations via the increased 3d-3d interactions.The second part involves the study of structural and electronic properties of phase-change memory materials (PCMs), i. e., Ge2Sb2Te5 (GST) and Ga-doped In2O3. Van der Waals (vdW) interaction must be considered to obtain accurate crystal structure of layered GST. For Ga-doped In2O3 (GIO), the local structure of amorphous GIO is found to resemble that of amorphous In2O3, except the vicinity of doping atoms. The electronic property of a-GIO is metallic, which considerably differs from the semiconducting feature of the crystalline GIO. This emphasizes the contrast in the conductivity of the crystalline and amorphous upon phase switching of GIO.The third part associates with the search for clean-energy materials, viz., hydrogen production, hydrogen storage and green Mg-ion batteries. For hydrogen production, the role of intrinsic point defects to water adsorption on ZnO(10-10) surface is investigated. The findings show that the Zn and O defect-sites are energetically not favorable for the water adsorption and dissociation. For the purpose of storing hydrogen in a solid phase, silicene, doped by alkaline and alkaline earth metals, is investigated. We find that Li-doped and Na-doped silicene can attain the superior storage capacity. For cathode material of Mg-ion batteries, Mg2Mo6S8, the diffusivity of Mg ions occurs through an available channel in the bulk with the onset temperature of 200 K.
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