SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:uu ;mspu:(patent)"

Sökning: LAR1:uu > Patent

  • Resultat 11-20 av 304
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  •  
12.
  •  
13.
  • Becker, Juliane, et al. (författare)
  • MULTIPLE ORTHOGONAL LABELLING OF OLGONUCLEOTIDES
  • 2016
  • Patent (populärvet., debatt m.m.)abstract
    • In Summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing the inverse Diels-Alder reaction (DAinv) and the copper-catalyzed click reaction (CuAAC), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture prefer ably for one hour at room temperature. In detail, the reaction components are one or more N-modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more N3-re active groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as N3-re active group(s) and afrans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more pref erably frans-cyclooctene. Therefore, the present invention provides a one-pot method for post-synthetic multiple orthogonal labeling of oligonucleotides, which allows the site-specific introduction of more than one label, preferably of at least two labels into oligonucleotides after solid-phase synthesis, wherein the DAinv takes place on the dienophile modification only and the CuAAC selectively takes place on the N3-reactive group modification.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  •  
18.
  •  
19.
  •  
20.
  • Besidski, Yevgeni, et al. (författare)
  • Preparation of aminotriazole compounds as gamma secretase modulators useful for treatment of Aβ-related diseases.
  • 2014
  • Patent (populärvet., debatt m.m.)abstract
    • The invention relates to aminotriazole compds. of formula I and pharmaceutically acceptable salts and pharmaceutical compns. thereof, as well as processes for making these compds. for use in the treatment and/or prevention of Aβ-related diseases. I [wherein A is (un)substituted 5- or 6-membered heteroaryl ring comprising at least one N; R1 is H, C1-3-alkyl, cyano, etc.; R2 is (un)substituted C1-6-alkyl, C3-7-cycloalkyl-C1-3-alkyl, heterocyclyl-C1-3-alkyl, etc.; R3 and R4 are each independently selected from H, C1-6-alkyl, (un)substituted C3-7-cycloalkyl, etc.] or pharmaceutically acceptable salts thereof are claimed and exemplified. Example compd. II was prepd. from the reaction of 3-bromo-N-(cyclopropylmethyl)-1-methyl-1H-1,2,4-triazol-5-amine with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline dihydrochloride under Buchwald-Hartwig conditions in 26% yield. Nine compds. of I were evaluated for inhibition of Aβ formation utilizing electrochemiluminescence anal. and HEK cells expressing amyloid precursor protein (data given). [on SciFinder(R)]
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 304
Typ av publikation
patent  (304)Ta bort avgränsningen
Typ av innehåll
populärvet., debatt m.m. (300)
övrigt vetenskapligt/konstnärligt (4)
Författare/redaktör
Hagersten, Erik (45)
Zhen, Zhang, 1979- (42)
Strømme, Maria, 1970 ... (25)
Engqvist, Håkan (21)
Mihranyan, Albert, 1 ... (18)
Xia, Wei (17)
visa fler...
Strömme, Maria (11)
Lavoie, C. (11)
Caldwell, K. D. (9)
Yang, B (8)
Granqvist, C. G. (8)
Yngve, Ulrika. (7)
Jansson, Ulf (7)
Schaal, Wesley, PhD (7)
Nyholm, Leif (7)
Pelcman, Benjamin (7)
Olofsson, Kristofer (7)
Ozcan, A (6)
Zhang, Z. (5)
Svedlindh, Peter (5)
Strömberg, Mattias (5)
Gunnarsson, Klas (5)
Wilhelmsson, Ola (5)
Lewin, Erik, 1979- (5)
Risch, Tore (5)
Mihranyan, Albert (5)
Yngve, Ulrika, 1972- (5)
Huang, S.C. (5)
Herron, J.N. (5)
Christensen, D.A. (5)
Nilsson, Mats (4)
Hagfeldt, Anders (4)
Edvinsson, Tomas (4)
Yang, Xichuan (4)
Herrmann, Andreas (4)
Bergström, Jan (4)
Tian, Haining (4)
Garcia-Bennett, Alfo ... (4)
Söderberg, Lennart (4)
Azens, A (4)
Göransson, Jenny (4)
Suna, Edgars (4)
Erk, Peter (4)
Khater, M (4)
Eickemeyer, Felix (4)
Schoeneboom, Jan (4)
Frykstrand, Sara (4)
Li, Chen (4)
Muellen, Klaus (4)
Engman, Lars, 1952- (4)
visa färre...
Lärosäte
Uppsala universitet (304)
Språk
Engelska (294)
Tyska (2)
Ryska (2)
Kinesiska (2)
Svenska (1)
Franska (1)
visa fler...
Japanska (1)
Koreanska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Teknik (74)
Naturvetenskap (32)
Medicin och hälsovetenskap (19)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy