| 542371. |
- Lind, Tore, et al.
(författare)
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Eradication of Helicobacter pylori Using One-week Triple Therapies Combining Omeprazole with Two Antimicrobials : The MACH I Study
- 1996
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Ingår i: Helicobacter. - : Wiley. - 1083-4389 .- 1523-5378. ; 1:3, s. 138-144
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Tidskriftsartikel (refereegranskat)abstract
- Background.Eradication of Helicobacter pylori provides potential cure in the majority of patients with peptic ulcer disease, and eradication rates of more than 90% have been reported, using omeprazole in combination with two antimicrobials. The choice of antimicrobials, dose regimen and duration of treatment have varied between studies, however, and an optimal treatment still has to be established.Materials and Methods.We conducted an international, randomized, double-blind, placebo-controlled study involving more than 100 patients in each of six treatment groups in 43 hospital gastrointestinal units in Canada, Germany, Ireland, Sweden, and the United Kingdom. Patients (n=787) with proved duodenal ulcer disease were randomized to treatment twice daily for 1 week with omeprazole, 20 mg (O), plus either placebo (P) or combinations of two of the following anti-microbials: amoxicillin, 1 gm (A), clarithromycin, 250 or 500 mg (C250, C500), or metronidazole, 400 mg (M). Eradication of H. pylori was evaluated by 13C-UBT, performed before and 4 weeks after treatment cessation.Results.The eradication rates for the all-patients-treated analysis were 96%. OAC500; 95%, OMC250; 90%, OMC500; 84%, OAC250; 79%, OAM; and 1%, OP. OAC500 and OMC250 achieved eradication rates with lower 95% confidence interval limits exceeding 90%. All regimens were well-tolerated, 96% of patients complied with their dose regimen, and 2.3% of the patients discontinued treatment owing to adverse events.Conclusions.Omeprazole triple therapies given twice daily for 1 week produce high eradication rates, are well-tolerated, and are associated with high patient compliance. The two most effective therapies were those combining omeprazole, 20 mg, with either amoxicillin, 1 gm, plus clarithromycin, 500 mg, or metronidazole, 400 mg, plus clarithromycin, 250 mg, all given twice daily.
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| 542372. |
- Lind, Thomas, et al.
(författare)
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Excessive dietary intake of vitamin A reduces skull bone thickness in mice
- 2017
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:4
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Tidskriftsartikel (refereegranskat)abstract
- Calvarial thinning and skull bone defects have been reported in infants with hypervitaminosis A. These findings have also been described in humans, mice and zebrafish with loss-of-function mutations in the enzyme CYP26B1 that degrades retinoic acid (RA), the active metabolite of vitamin A, indicating that these effects are indeed caused by too high levels of vitamin A and that evolutionary conserved mechanisms are involved. To explore these mechanisms, we have fed young mice excessive doses of vitamin A for one week and then analyzed the skull bones using micro computed tomography, histomorphometry, histology and immunohistochemistry. In addition, we have examined the effect of RA on gene expression in osteoblasts in vitro. Compared to a standard diet, a high dietary intake of vitamin A resulted in a rapid and significant reduction in calvarial bone density and suture diastasis. The bone formation rate was almost halved. There was also increased staining of tartrate resistant acid phosphatase in osteocytes and an increased perilacunar matrix area, indicating osteocytic osteolysis. Consistent with this, RA induced genes associated with bone degradation in osteoblasts in vitro. Moreover, and in contrast to other known bone resorption stimulators, vitamin A induced osteoclastic bone resorption on the endocranial surfaces.
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| 542373. |
- Lind, Torgny, et al.
(författare)
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Extension, advice and knowledge systems for private forestry: Understanding diversity and change across Europe
- 2020
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Ingår i: Land Use Policy. - : Elsevier BV. - 0264-8377 .- 1873-5754. ; 94
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Tidskriftsartikel (refereegranskat)abstract
- The decisions and actions of private forest owners are important for the delivery of forest goods and services. Both forest ownership, and policies related to forest owners, are changing. Traditionally in most countries, government extension officers have advised and instructed forest owners, but this is evolving, with greater importance given to a range of actors, objectives, and knowledge types. Drawing on literature and mixed data from 10 countries in Europe, this paper explores how forestry advisory systems can be conceptualized, and describes their current situation in Europe. Drawing parallels with the concept of AKIS (Agricultural Knowledge and Information Systems), we propose the term FOKIS (FOrestry Knowledge and Information Systems), as both a system (a purposeful and interdependent group of bodies) and a method for understanding such systems. We define four dimensions for describing FOKIS: owners, policy goals, advice providers, and tools. We find different roles for extension in countries with centrally controlled, highly regulated forest management, and advisors in regions where forest owners have more freedom to choose how to manage their forest. We find five trends across Europe: increasing flexibility, openness and participation of owners as sources of information; increasing reliance on information and persuasion rather than enforced compliance; a shift of attention from timber to a wider range of ecosystem services such as biodiversity and recreation; a shift of funding and providers from public to private sector; emergence of new virtual communication tools. The approach provides a way to make sense of comparisons and change in FOKIS, and opens up an important research field.
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| 542374. |
- Lind, Torgny
(författare)
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Growing stock monitoring by European National Forest Inventories: Historical origins, current methods and harmonisation
- 2022
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Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 505
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Tidskriftsartikel (refereegranskat)abstract
- Wood resources have been essential for human welfare throughout history. Also nowadays, the volume of growing stock (GS) is considered one of the most important forest attributes monitored by National Forest Inventories (NFIs) to inform policy decisions and forest management planning. The origins of forest inventories closely relate to times of early wood shortage in Europe causing the need to explore and plan the utilisation of GS in the catchment areas of mines, saltworks and settlements. Over time, forest surveys became more detailed and their scope turned to larger areas, although they were still conceived as stand-wise inventories. In the 1920s, the first sample-based NFIs were introduced in the northern European countries. Since the earliest beginnings, GS monitoring approaches have considerably evolved. Current NFI methods differ due to country-specific conditions, inventory traditions, and information needs. Consequently, GS estimates were lacking international comparability and were therefore subject to recent harmonisation efforts to meet the increasing demand for consistent forest resource information at European level. As primary large-area monitoring programmes in most European countries, NFIs assess a multitude of variables, describing various aspects of sustainable forest management, including for example wood supply, carbon sequestration, and biodiversity. Many of these contemporary subject matters involve considerations about GS and its changes, at different geographic levels and time frames from past to future developments according to scenario simulations. Due to its historical, continued and currently increasing importance, we provide an up-to-date review focussing on large-area GS monitoring where we i) describe the origins and historical development of European NFIs, ii) address the terminology and present GS definitions of NFIs, iii) summarise the current methods of 23 European NFIs including sampling methods, tree measurements, volume models, estimators, uncertainty components, and the use of air-and space-borne data sources, iv) present the recent progress in NFI harmonisation in Europe, and v) provide an outlook under changing climate and forest-based bioeconomy objectives.
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| 542375. |
- Lind, Torgny, et al.
(författare)
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Harmonisation of stem volume estimates in European National Forest Inventories
- 2019
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Ingår i: Annals of Forest Science. - : Springer Science and Business Media LLC. - 1286-4560 .- 1297-966X. ; 76
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Tidskriftsartikel (refereegranskat)abstract
- Key messageVolume predictions of sample trees are basic inputs for essential National Forest Inventory (NFI) estimates. The predicted volumes are rarely comparable among European NFIs because of country-specific dbh-thresholds and differences regarding the inclusion of the tree parts stump, stem top, and branches. Twenty-one European NFIs implemented harmonisation measures to provide consistent stem volume predictions for comparable forest resource estimates.ContextThe harmonisation of forest information has become increasingly important. International programs and interest groups from the wood industry, energy, and environmental sectors require comparable information. European NFIs as primary source of forest information are well-placed to support policies and decision-making processes with harmonised estimates.AimsThe main objectives were to present the implementation of stem volume harmonisation by European NFIs, to obtain comparable growing stocks according to five reference definitions, and to compare the different results.MethodsThe applied harmonisation approach identifies the deviations between country-level and common reference definitions. The deviations are minimised through country-specific bridging functions. Growing stocks were calculated from the un-harmonised, and harmonised stem volume estimates and comparisons were made.ResultsThe country-level growing stock results differ from the Cost Action E43 reference definition between -8 and +32%. Stumps and stem tops together account for 4 to 13% of stem volume, and large branches constitute 3 to 21% of broadleaved growing stock. Up to 6% of stem volume is allocated below the dbh-threshold.ConclusionComparable volume figures are available for the first time on a large-scale in Europe. The results indicate the importance of harmonisation for international forest statistics. The presented work contributes to the NFI harmonisation process in Europe in several ways regarding comparable NFI reporting and scenario modelling.
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| 542376. |
- Lind, Torgny, et al.
(författare)
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Harmonised projections of future forest resources in Europe
- 2019
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Ingår i: Annals of Forest Science. - : Springer Science and Business Media LLC. - 1286-4560 .- 1297-966X. ; 76
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Tidskriftsartikel (refereegranskat)abstract
- center dot Key message A dataset of forest resource projections in 23 European countries to 2040 has been prepared for forest-related policy analysis and decision-making. Due to applying harmonised definitions, while maintaining country-specific forestry practices, the projections should be usable from national to international levels. The dataset can be accessed at 10.5061/dryad.4t880qh. The associated metadata are available at https://metadata-afs.nancy.inra.fr/geonetwork/srv/eng/catalog.search#/metadata/8f93e0d6-b524-43bd-bdb8-621ad5ae6fa9.
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| 542377. |
- Lind, Thomas, et al.
(författare)
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High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats
- 2011
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Ingår i: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 48:3, s. 496-506
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Tidskriftsartikel (refereegranskat)abstract
- Vitamin A (retinol) is the only molecule known to induce spontaneous fractures in laboratory animals and we have identified retinol as a risk factor for fracture in humans. Since subsequent observational studies in humans and old animal data both show that high retinol intake appears to only have small effects on bone mineral density (BMD) we undertook a mechanistic study of how excess retinol reduces bone diameter while leaving BMD essentially unaffected. We fed growing rats high doses of retinol for only 1week. Bone analysis involved antibody-based methods, histology, pQCT, biomechanics and bone compartment-specific PCR together with Fourier Transform Infrared Spectroscopy of bone mineral. Excess dietary retinol induced weakening of bones with little apparent effect on BMD. Periosteal osteoclasts increased but unexpectedly endosteal osteoclasts disappeared and there was a reduction of osteoclastic serum markers. There was also a lack of capillary erythrocytes, endothelial cells and serum retinol transport protein in the endosteal/marrow compartment. A further indication of reduced endosteal/marrow blood flow was the increased expression of hypoxia-associated genes. Also, in contrast to the inhibitory effects in vitro, the marrow of retinol-treated rats showed increased expression of osteogenic genes. Finally, we show that hypervitaminotic bones have a higher degree of mineralization, which is in line with biomechanical data of preserved stiffness in spite of thinner bones. Together these novel findings suggest that a rapid primary effect of excess retinol on bone tissue is the impairment of endosteal/marrow blood flow leading to hypoxia and pathological endosteal mineralization.
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| 542378. |
- Lind, Thomas, et al.
(författare)
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Increased Bone Mass in Female Mice Lacking Mast Cell Chymase
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:12
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Tidskriftsartikel (refereegranskat)abstract
- Here we addressed the potential impact of chymase, a mast-cell restricted protease, on mouse bone phenotype. We show that female mice lacking the chymase Mcpt4 acquired a persistent expansion of diaphyseal bone in comparison with wild type controls, reaching a 15% larger diaphyseal cross sectional area at 12 months of age. Mcpt4(-/-) mice also showed increased levels of a bone anabolic serum marker and higher periosteal bone formation rate. However, they were not protected from experimental osteoporosis, suggesting that chymase regulates normal bone homeostasis rather than the course of osteoporosis. Further, the absence of Mcpt4(-/-) resulted in age-dependent upregulation of numerous genes important for bone formation but no effects on osteoclast activity. In spite of the latter, Mcpt4(-/-) bones had increased cortical porosity and reduced endocortical mineralization. Mast cells were found periosteally and, notably, bone-proximal mast cells in Mcpt4(-/-) mice were degranulated to a larger extent than in wild type mice. Hence, chymase regulates degranulation of bone mast cells, which could affect the release of mast cell-derived factors influencing bone remodelling. Together, these findings reveal a functional impact of mast cell chymase on bone. Further studies exploring the possibility of using chymase inhibitors as a strategy to increase bone volume may be warranted.
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| 542379. |
- Lind, Torbjörn, et al.
(författare)
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Iron and zinc interactions : reply to FT Wieringa et al
- 2004
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Ingår i: American Journal of Clinical Nutrition. - Bethesda : American society of clinical nutrition. - 0002-9165 .- 1938-3207. ; 80:3, s. 789-790
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Tidskriftsartikel (refereegranskat)
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| 542380. |
- Lind, Torbjörn, et al.
(författare)
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Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age
- 2008
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 97:6, s. 770-775
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Tidskriftsartikel (refereegranskat)abstract
- Background: General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. Objective: A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb >= 113 g/L and S-ferritin >= 33 mu g/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. Results: Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 mu g/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 mu mol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. Conclusion: In our study, iron supplementation of IR infants affected WAZ adversely, whereas iron supplementation to non-iron-replete infants did not affect growth. These results support a cautious approach to iron supplementation of IR infants.
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