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Sökning: WFRF:(Ahlgren Christina)

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  • Föregående 1234[5]67Nästa
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41.
  • Pohl, Petra, et al. (författare)
  • Äldre män och kvinnor som med-aktörer i design av tränings-appar för fallprevention
  • 2013
  • Konferensbidrag (refereegranskat)abstract
    • Bakgrund och syfte:Det finns en uppsjö av olika fallpreventiva evidensbaserade träningsprogram för äldre i ordinärt boende. Även om evidensgraden är hög för viss träning finns det svårigheter med att få äldre personer att utföra träningen. Vissa motivationsfaktorer och hindrande faktorer har redan identifierats och forskningen visar att skräddarsydda, hembaserade träningsprogram med möjlighet till regelbunden återkoppling är det som fungerar bäst. Applikationer till mobiltelefoner och surfplattor erbjuder denna möjlighet, och har funnits sedan en längre tid, men dessa vänder sig oftast till yngre och medelålders personer. Det finns ännu ingen applikation som är baserad på de äldres egna önskemål. Syftet med studien är att undersöka hur friska äldre män och kvinnor i ordinärt boende resonerar och vilka övningar de föredrar när de deltar i utveckling och design av ett fallpreventivt träningsprogram i form av en applikation till smarta telefoner och surfplattor. Metoder:18 deltagare > 70 år. Deltagande och uppskattande aktionsforskning samt fokusgruppsintervjuer och workshops. Kvalitativ innehållsanalys. Resultat:De preliminära resultaten visar att när äldre män och kvinnor i ordinärt boende deltar i utvecklingen av ett fallpreventivt träningsprogram för smarta telefoner och surfplattor har de många idéer, tankar och erfarenheter som kan fungera som motiverande faktorer i syfte att utföra regelbunden fallpreventiv träning. Konklusion:Implementeringen och följsamheten för evidensbaserade fallpreventiva träningsprogram är otillräcklig. Denna studie bidrar med kunskaper för att designa skräddarsydda, hembaserade fallpreventiva träningsprogram för friska äldre personer i ordinärt boende.
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42.
  • Ranatunga, Wasantha, et al. (författare)
  • Architecture of the human mitochondrial iron-sulfur cluster assembly machinery
  • 2016
  • Ingår i: Journal of Biological Chemistry. - ASBMB. - 0021-9258. ; 291:40, s. 21296-21321
  • Tidskriftsartikel (refereegranskat)abstract
    • Fe-S clusters, essential cofactors needed for the activity of many different enzymes, are assembled by conserved protein machineries inside bacteria and mitochondria. As the architecture of the human machinery remains undefined, we co-expressed in Escherichia coli the following four proteins involved in the initial step of Fe-S cluster synthesis: FXN42-210 (iron donor); [NFS1]·[ISD11] (sulfur donor); and ISCU (scaffold upon which new clusters are assembled). We purified a stable, active complex consisting of all four proteins with 1:1:1:1 stoichiometry. Using negative staining transmission EM and single particle analysis, we obtained a three-dimensional model of the complex with ∼14 Å resolution. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN42-210]24·[NFS1]24·[ISD11]24·[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components. The complex structure fulfills distance constraints obtained from chemical cross-linking of the complex at multiple recurring interfaces, involving hydrogen bonds, salt bridges, or hydrophobic interactions between conserved residues. The complex consists of a central roughly cubic [FXN42-210]24·[ISCU]24 sub-complex with one symmetric ISCU trimer bound on top of one symmetric FXN42-210 trimer at each of its eight vertices. Binding of 12 [NFS1]2·[ISD11]2 sub-complexes to the surface results in a globular macromolecule with a diameter of ∼15 nm and creates 24 Fe-S cluster assembly centers. The organization of each center recapitulates a previously proposed conserved mechanism for sulfur donation from NFS1 to ISCU and reveals, for the first time, a path for iron donation from FXN42-210 to ISCU.
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43.
  • Sand, Fredrik Wolfhagen, et al. (författare)
  • Growth-limiting role of endothelial cells in endoderm development
  • 2011
  • Ingår i: Developmental Biology. - Academic Press. - 0012-1606. ; 352:2, s. 267-277
  • Tidskriftsartikel (refereegranskat)abstract
    • Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs.
44.
  • Sandlund, Marlene, et al. (författare)
  • Gender perspective on older people’s exercise preferences and motivators in the context of falls prevention a qualitative Study
  • 2018
  • Ingår i: BioMed Research International. - Hindawi Publishing Corporation. - 2314-6133.
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Several factors have previously been identified to positively influence the uptake and adherence for fall prevention exercise programmes. There is, however, a lack of studies investigating if men and women differ in their views and preferences for fall prevention exercises. Aim. To explore exercise preferences and motivators of older community-dwelling women and men in the context of falls prevention from a gender perspective. Methods. Workshops including multistage focus group discussions were conducted with 18 older community-dwelling people with and without history of falls. Participants were purposively selected and divided into two groups. Each group met on six occasions over a period of five months. Participatory and Appreciative Action and Reflection methodology was used to guide the discussions. A qualitative content analysis approach was used in the analysis. Results. Older participants had many diverse preferences and confirmed that individually tailored exercise, in terms of mode, intensity, challenge, and social context, is important. Moreover, important factors for exercise adherence and maintenance included the experience of individual confirmation; different spirit lifters to increase enjoyment; and personal tricks to maintain exercise routines. The individual differences within genders were more diverse than the differences between women and men. Conclusion. Exercise interventions to prevent falls should be individually tailored, based on the specific needs and preferences of the older participant, and do not appear to require gender specific approaches. To increase adherence, intrinsic motivation for exercise may be encouraged by competence enhancing confirmations, energizing spirit lifters, and practical tips for exercise maintenance. The study provides an awareness about women’s and men’s preferences for fall prevention exercises, and this information could be used as guidance in designing inclusive exercise interventions.
45.
  • Sandlund, Marlene, et al. (författare)
  • Gender Perspective on Older People’s Preferences for Exercises in the Context of Falls Prevention : A qualitative study
  • ????
  • Annan publikation (övrigt vetenskapligt)abstract
    • The aim with this study was to explore the preferences of community-dwelling older women and men regarding exercise characteristics in the context of preventing falls. Multistage focus group discussions were conducted with 18 older community-dwelling people with or without a history of falls. Participants were purposively sampled, and divided into two groups. Each group met six times. Participatory and Appreciative Action and Reflection methodology was used to guide the discussions. A qualitative content analysis approach was used in the analysis. Six categories emerged from the analysis. Two categories were related to motives and barriers for uptake, and four categories were related to adherence and maintenance: exercise characteristics; confirmation; spirit lifters and maintenance tricks. Small differences and many similarities in what women and men perceived as motivating factors in an exercise situation were displayed. To conclude, older people have many diverse preferences regarding exercise in the context of preventing falls, and the individual differences within genders seem to be greater than the differences between men and women. Exercise interventions to prevent falls should be individually tailored based on the specific needs and preferences of the older participant. In order to encourage internalization and intrinsic motivation for exercises, autonomy-supportive approaches may be applied and accompanied by competence strengthening confirmations, energizing spirit lifters and practical tips for exercise maintenance
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46.
  • Sandlund, Marlene, et al. (författare)
  • Gender perspectives on views and preferences of older people on exercise to prevent falls a systematic mixed studies review
  • 2017
  • Ingår i: BMC Geriatrics. - BioMed Central. - 1471-2318. ; 17
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: To offer fall prevention exercise programs that attract older people of both sexes there is a need to understand both women's and men's views and preferences regarding these programs. This paper aims to systematically review the literature to explore any underlying gender perspectives or gender interpretations on older people's views or preferences regarding uptake and adherence to exercise to prevent falls. Methods: A review of the literature was carried out using a convergent qualitative design based on systematic searches of seven electronic databases (PubMed, CINAHL, Amed, PsycINFO, Scopus, PEDro, and OTseeker). Two investigators identified eligible studies. Each included article was read by at least two authors independently to extract data into tables. Views and preferences reported were coded and summarized in themes of facilitators and barriers using a thematic analysis approach. Results: Nine hundred and nine unique studies were identified. Twenty five studies met the criteria for inclusion. Only five of these contained a gender analysis of men's and women's views on fall prevention exercises. The results suggests that both women and men see women as more receptive to and in more need of fall prevention messages. The synthesis from all 25 studies identified six themes illustrating facilitators and six themes describing barriers for older people either starting or adhering to fall prevention exercise. The facilitators were: support from professionals or family; social interaction; perceived benefits; a supportive exercise context; feelings of commitment; and having fun. Barriers were: practical issues; concerns about exercise; unawareness; reduced health status; lack of support; and lack of interest. Considerably more women than men were included in the studies. Conclusion: Although there is plenty of information on the facilitators and barriers to falls prevention exercise in older people, there is a distinct lack of studies investigating differences or similarities in older women's and men's views regarding fall prevention exercise. In order to ensure that fall prevention exercise is appealing to both sexes and that the inclusion of both men and women are encouraged, more research is needed to find out whether gender differences exists and whether practitioners need to offer a range of opportunities and support strategies to attract both women and men to falls prevention exercise.
47.
  • Sandlund, Marlene, et al. (författare)
  • Older women and men as co-creators in design of a mobile application for fall prevention
  • 2013
  • Konferensbidrag (refereegranskat)abstract
    • IntroductionThere is a plethora of fall prevention programs for older community-dwelling people. The evidence for exercise-based programs is strong. There is a problem however with implementation and adherence. Motivational factors and barriers have been identified to some extent. Previous studies have shown that what works best is when exercise programs are tailor made, home based, and when people have access to personal feedback on a regular basis. Mobile applications for Smartphones with exercises have these advantages, and have been available for a long time, but these are most commonly directed to young and middle-aged people. There are no applications for fall prevention developed based on senior’s own wishes. The aim was to investigate how healthy older community-dwelling women and men reason and what exercises they prefer when participating in development and design of a fall prevention program in shape of a mobile application for Smartphones.Method Participatory and appreciative action research design with focus group interviews and workshops. Qualitative data analysis.Results The preliminary results show that when older community-dwelling men and women participate in developing a fall prevention program for Smartphones, they have many ideas, thoughts and experiences that may serve as a motivational factor for following a fall prevention program regularly.ConclusionThe implementation and adherence for evidence based fall preventative exercise programs is insufficient. This study will gain knowledge to design tailor made, home based fall prevention exercise programs among community-dwelling healthy seniors.
48.
  • Sonntag-Öström, Elisabet, 1958-, et al. (författare)
  • “Nature's effect on my mind” patients’ qualitative experiences of a forest-based rehabilitation programme
  • 2015
  • Ingår i: Urban Forestry & Urban Greening. - Elsevier. - 1618-8667. ; 14:3, s. 607-614
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: The aim of this study was to investigate the personal experiences and perceived effects on mind from visits to forest environments in a subset of patients with severe exhaustion disorder (ED), who participated in a randomized controlled trial for evaluation of forest-based rehabilitation.Participants: A subsample of 19 patients with diagnosed ED, who completed the three-month forest-based rehabilitation programme in the ForRest project, was interviewed. Method: The forest-based rehabilitation consisted of repeated forest visits with the main objective of spending time in rest and solitude in a chosen forest setting. Semi-structured interviews were carried out and analysed using Grounded Theory.Result: A core category and five subcategories were set up to describe the patients’ experiences and development during the forest-based rehabilitation. As patients mostly reported that they strove to achieve peace of mind during the forest visits, Striving for serenity was chosen to be the core category. At first the patients were frustrated when left alone with their own thoughts in an unfamiliar forest environment. They gradually became familiar with the forest environments and also found their favourite places where they experienced peace of mind. They were then able to rest and begin reflective thinking about their life situation, which led to ambitions to change it.The preferred forest environments were characterised by openness, light and a good view, and were felt to be undemanding, peaceful and stimulating.Conclusion: Visits to the forest provided favourite places for rest, were experienced as restorative, seemed to improved reflection and may have contributed to starting the coping process for these patients. However, forest visits, as the only treatment option, are not sufficient as rehabilitation from severe and long-term ED. We suggest that forest visits should be integrated with cognitive behavioural therapy to further improve the recovery and enhance coping in daily life for these patients.
49.
  • Stenberg, Gunilla, 1968-, et al. (författare)
  • A gender perspective on physiotherapy treatment in patients with neck and back pain
  • 2010
  • Ingår i: Advances in Physiotherapy. - Informa Healthcare. - 1403-8196. ; 12:1, s. 35-41
  • Tidskriftsartikel (refereegranskat)abstract
    • Women report more pain from the musculoskeletal system, and more disability, than do men. As a consequence, women more often seek healthcare than men do, and are more often on sick leave. Research shows that female patients and male patients are treated differently by physicians and that the physician's gender also influenced the choice of treatment. The aim was to study whether the patients’ and/or the physiotherapists’ gender influences physiotherapy treatments for patients with neck and/or low back pain. During 3 days in April 2006, 73 physiotherapists in primary care and private practices collected information on 586 patients with neck and/or low back pain. The information included data on the affected pain sites and the treatment procedures used by the physiotherapist. Baseline data on the physiotherapists were collected with a questionnaire. The results showed that female and male physiotherapists mainly used the same treatment procedures, but with some differences. The female physiotherapists used significantly more acupuncture and procedures directed toward treatment of mental function. They also gave their patients a unique combination of treatment procedures to a greater extent than their male colleagues. The malte physiotherapists used significantly more training of joint mobility. Male and female patients were given the same treatment.
50.
  • Stenberg, Gunilla, et al. (författare)
  • "Getting confirmation" gender in expectations and experiences of healthcare for neck or back patients
  • 2012
  • Ingår i: Journal of Rehabilitation Medicine. - 1650-1977. ; 44:2, s. 163-171
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The aim of this study was to explore, from a gender perspective, patients' expectations prior to seeking healthcare for neck or back pain, and their subsequent experiences of the care and rehabilitation they received. Methods: Thematized interviews with 12 patients, 7 women and 5 men, using open-ended questions, were analysed according to grounded theory. Each patient was interviewed before their first appointment with a physiotherapist or general practitioner and 3 months later. Results: Analysis resulted in 5 categories: "To be taken seriously", "Getting an explanation", "To be invited to participate", "To be assessed and treated individually", and "To be taken care of in a trustworthy environment", which were linked by a core category "Getting confirmation". Two ideal types were identified: the "Confident" type, characterized by self-confidence and pride, and the "Ambiguous" type, characterized by disparagement and shame. The categories were partly perceived in different ways from the two ideal types. The ideal types were not defined by sex; however, more men were found to be of the "Confident" type and more women of the "Ambiguous" type. Conclusion: Gender appears to affect expectations and experiences, in addition to how patients view and express their problems. Healthcare professionals should take this into account in consultations.
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