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Sökning: WFRF:(Carlson Christopher S)

  • Resultat 11-15 av 15
  • Föregående 1[2]
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  • Eastwood, J. P., et al. (författare)
  • THEMIS observations of a hot flow anomaly : Solar wind, magnetosheath, and ground-based measurements
  • 2008
  • Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 35:17, s. L17S03-
  • Tidskriftsartikel (refereegranskat)abstract
    • The THEMIS spacecraft encountered a Hot Flow Anomaly ( HFA) on the dusk flank of the Earth's bow shock on 4 July 2007, observing it on both sides of the shock. Meanwhile, the THEMIS ground magnetometers traced the progress of the associated Magnetic Impulse Event along the dawn flank of the magnetosphere, providing a unique opportunity to study the transmission of the HFA through the shock and the subsequent downstream response. THEMIS-A, in the solar wind, observed classic HFA signatures. Isotropic electron distributions inside the upstream HFA are attributed to the action of the electron firehose instability. THEMIS-E, just downstream, observed a much more complex disturbance with the pressure perturbation decoupled from the underlying discontinuity. Simple calculations show that the pressure perturbation would be capable of significantly changing the magnetopause location, which is confirmed by the ground-based observations.
  • Schick, Ursula M, et al. (författare)
  • Association of exome sequences with plasma C-reactive protein levels in >9000 participants.
  • 2015
  • Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906. ; 24:2, s. 559-571
  • Tidskriftsartikel (refereegranskat)abstract
    • C-reactive protein (CRP) concentration is a heritable systemic marker of inflammation that is associated with cardiovascular disease risk. Genome-wide association studies have identified CRP-associated common variants associated in ∼25 genes. Our aims were to apply exome sequencing to (1) assess whether the candidate loci contain rare coding variants associated with CRP levels and (2) perform an exome-wide search for rare variants in novel genes associated with CRP levels. We exome-sequenced 6050 European-Americans (EAs) and 3109 African-Americans (AAs) from the NHLBI-ESP and the CHARGE consortia, and performed association tests of sequence data with measured CRP levels. In single-variant tests across candidate loci, a novel rare (minor allele frequency = 0.16%) CRP-coding variant (rs77832441-A; p.Thr59Met) was associated with 53% lower mean CRP levels (P = 2.9 × 10(-6)). We replicated the association of rs77832441 in an exome array analysis of 11 414 EAs (P = 3.0 × 10(-15)). Despite a strong effect on CRP levels, rs77832441 was not associated with inflammation-related phenotypes including coronary heart disease. We also found evidence for an AA-specific association of APOE-ε2 rs7214 with higher CRP levels. At the exome-wide significance level (P < 5.0 × 10(-8)), we confirmed associations for reported common variants of HNF1A, CRP, IL6R and TOMM40-APOE. In gene-based tests, a burden of rare/lower frequency variation in CRP in EAs (P ≤ 6.8 × 10(-4)) and in retinoic acid receptor-related orphan receptor α (RORA) in AAs (P = 1.7 × 10(-3)) were associated with CRP levels at the candidate gene level (P < 2.0 × 10(-3)). This inquiry did not elucidate novel genes, but instead demonstrated that variants distributed across the allele frequency spectrum within candidate genes contribute to CRP levels.
  • Stender, Joshua D, et al. (författare)
  • Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells
  • 2017
  • Ingår i: Molecular Cell. - Cambridge, United States : Cell Press. - 1097-2765 .- 1097-4164. ; 65:6, s. 1122-1135.e5
  • Tidskriftsartikel (refereegranskat)abstract
    • Human breast cancers that exhibit high proportions of immune cells and elevated levels of pro-inflammatory cytokines predict poor prognosis. Here, we demonstrate that treatment of human MCF-7 breast cancer cells with pro-inflammatory cytokines results in ERα-dependent activation of gene expression and proliferation, in the absence of ligand or presence of 4OH-tamoxifen (TOT). Cytokine activation of ERα and endocrine resistance is dependent on phosphorylation of ERα at S305 in the hinge domain. Phosphorylation of S305 by IKKβ establishes an ERα cistrome that substantially overlaps with the estradiol (E2)-dependent ERα cistrome. Structural analyses suggest that S305-P forms a charge-linked bridge with the C-terminal F domain of ERα that enables inter-domain communication and constitutive activity from the N-terminal coactivator-binding site, revealing the structural basis of endocrine resistance. ERα therefore functions as a transcriptional effector of cytokine-induced IKKβ signaling, suggesting a mechanism through which the tumor microenvironment controls tumor progression and endocrine resistance.
  • Eriksson, S., et al. (författare)
  • Magnetic island formation between large-scale flow vortices at an undulating postnoon magnetopause for northward interplanetary magnetic field
  • 2009
  • Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:2, s. A00C17-
  • Tidskriftsartikel (refereegranskat)abstract
    • Time History of Events and Macroscale Interactions during Substorms multispacecraft observations are presented for a similar to 2-h-long postnoon magnetopause event on 8 June 2007 that for the first time indicate that the trailing (sunward) edges of Kelvin-Helmholtz (KH) waves are commonly related to small-scale < 0.56 R-E magnetic islands or flux transfer events (FTE) during the growth phase of these surface waves. The FTEs typically show a characteristic bipolar B-N structure with enhanced total pressure at their center. Most of the small-scale FTEs are not related to any major plasma acceleration. TH-A observations of one small FTE at a transition from the low-latitude boundary layer (LLBL) into a magnetosheath plasma depletion layer were reconstructed using separate techniques that together confirm the presence of a magnetic island within the LLBL adjacent to the magnetopause. The island was associated with a small plasma vortex and both features appeared between two large-scale (similar to 1 R-E long and 2000 km wide) plasma vortices. We propose that the observed magnetic islands may have been generated from a time-varying reconnection process in a low ion plasma beta (beta(i) < 0.2) and low 8.3 degrees field shear environment at the sunward edge of the growing KH waves where the local magnetopause current sheet may be compressed by the converging flow of the large-scale plasma vortices as suggested by numerical simulations of the KH instability.
  • Fdez. Galván, Ignacio, et al. (författare)
  • OpenMolcas : From Source Code to Insight
  • Ingår i: Journal of Chemical Theory and Computation. - : The American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 15:11, s. 5925-5964
  • Forskningsöversikt (refereegranskat)abstract
    • In this Article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS product to the open-source platform. The paper initially describes the technical details of the new software development platform. This is followed by brief presentations of many new methods, implementations, and features of the OpenMolcas program suite. These developments include novel wave function methods such as stochastic complete active space self-consistent field, density matrix renormalization group (DMRG) methods, and hybrid multiconfigurational wave function and density functional theory models. Some of these implementations include an array of additional options and functionalities. The paper proceeds and describes developments related to explorations of potential energy surfaces. Here we present methods for the optimization of conical intersections, the simulation of adiabatic and nonadiabatic molecular dynamics, and interfaces to tools for semiclassical and quantum mechanical nuclear dynamics. Furthermore, the Article describes features unique to simulations of spectroscopic and magnetic phenomena such as the exact semiclassical description of the interaction between light and matter, various X-ray processes, magnetic circular dichroism, and properties. Finally, the paper describes a number of built-in and add-on features to support the OpenMolcas platform with postcalculation analysis and visualization, a multiscale simulation option using frozen-density embedding theory, and new electronic and muonic basis sets.
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