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  • Morrow, Christine, et al. (författare)
  • Integrating morphological and molecular taxonomy with the revised concept of Stelligeridae (Porifera : Demospongiae)
  • 2019
  • Ingår i: Zoological Journal of the Linnean Society. - OXFORD UNIV PRESS. - 0024-4082 .- 1096-3642. ; 187:1, s. 31-81
  • Tidskriftsartikel (refereegranskat)abstract
    • This study reinforces and extends the findings of previous molecular studies showing that there is a dose relationship between species assigned to the sponge genera Halicnemia, Higginsia, Paratimea and Stelligera and that the family Heteroxyidae is polyphyletic. The present study has led to the description of one new species of Halicnemia and six new species of Paratimea, the resurrection of Halicnemia gallica and a better understanding of the characters uniting Stelligeridae. A new species of Heteroxya is also described. We demonstrate that many of the taxa assigned to Heteroxyidae are more closely related to other families, and we propose several changes to the classification of Heteroscleromorpha. Desmoxyidae is resurrected from synonymy and transferred to Poecilosclerida; Higginsia anfractuosa is transferred to Hymedesmiidae, and a new genus, Hooperia, is erected for its reception; Higginsia durissima is returned to Bubaris (Bubaridae); Higginsia fragilis is transferred to Spanioplon (Hymedesmiidae); Hemiasterella camelus is transferred to Paratimea; and Raspailia (Parasyringella) australiensis and Ceratopsion axiferum are transferred to Adreus (Hemiasterellidae).
  • Muduli, Pranaba, et al. (författare)
  • Study of magnetic anisotropy and magnetization reversal using the quadratic magnetooptical effect in epitaxial CoxMnyGez(111) films
  • 2009
  • Ingår i: Journal of Physics : Condensed Matter. - 0953-8984. ; 21:29, s. 296005
  • Tidskriftsartikel (refereegranskat)abstract
    • Magnetic anisotropy, magnetization reversal and the magnetooptic Kerr effect in CoxMnyGez have been studied over a range of compositions between 0 and 50 at.% of Ge and between 1 and 3 in the Co to Mn atomic ratio, including the Heusler alloy Co2MnGe. A strong quadratic magnetooptic Kerr effect has been observed within a narrow region of composition centered around the Co to Mn atomic ratio of 2, which has been used to probe and quantify the magnetic anisotropy and magnetization reversal of the system. The anisotropy is sixfold with a weak uniaxial component, and it exhibits sensitive dependence on composition, especially on the atomic ratio between Co and Mn. The magnetization reversal process is consistent with the single-domain Stoner-Wohlfarth model.
  • Nelson, Robert G., et al. (författare)
  • Development of Risk Prediction Equations for Incident Chronic Kidney Disease
  • 2019
  • Ingår i: Journal of the American Medical Association (JAMA). - AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 322:21, s. 2104-2114
  • Tidskriftsartikel (refereegranskat)abstract
    • IMPORTANCE: Early identification of individuals at elevated risk of developing chronic kidney disease (CKD) could improve clinical care through enhanced surveillance and better management of underlying health conditions.OBJECTIVE: To develop assessment tools to identify individuals at increased risk of CKD, defined by reduced estimated glomerular filtration rate (eGFR).DESIGN, SETTING, AND PARTICIPANTS: Individual-level data analysis of 34 multinational cohorts from the CKD Prognosis Consortium including 5 222 711 individuals from 28 countries. Data were collected from April 1970 through January 2017. A 2-stage analysis was performed, with each study first analyzed individually and summarized overall using a weighted average. Because clinical variables were often differentially available by diabetes status, models were developed separately for participants with diabetes and without diabetes. Discrimination and calibration were also tested in 9 external cohorts (n = 2 253 540).EXPOSURES: Demographic and clinical factors.MAIN OUTCOMES AND MEASURES: Incident eGFR of less than 60 mL/min/1.73 m(2).RESULTS: Among 4 441 084 participants without diabetes (mean age, 54 years, 38% women), 660 856 incident cases (14.9%) of reduced eGFR occurred during a mean follow-up of 4.2 years. Of 781 627 participants with diabetes (mean age, 62 years, 13% women), 313 646 incident cases (40%) occurred during a mean follow-up of 3.9 years. Equations for the 5-year risk of reduced eGFR included age, sex, race/ethnicity, eGFR, history of cardiovascular disease, ever smoker, hypertension, body mass index, and albuminuria concentration. For participants with diabetes, the models also included diabetes medications, hemoglobin A(1c), and the interaction between the 2. The risk equations had a median C statistic for the 5-year predicted probability of 0.845 (interquartile range [IQR], 0.789-0.890) in the cohorts without diabetes and 0.801 (IQR, 0.750-0.819) in the cohorts with diabetes. Calibration analysis showed that 9 of 13 study populations (69%) had a slope of observed to predicted risk between 0.80 and 1.25. Discrimination was similar in 18 study populations in 9 external validation cohorts; calibration showed that 16 of 18 (89%) had a slope of observed to predicted risk between 0.80 and 1.25.CONCLUSIONS AND RELEVANCE: Equations for predicting risk of incident chronic kidney disease developed from more than 5 million individuals from 34 multinational cohorts demonstrated high discrimination and variable calibration in diverse populations. Further study is needed to determine whether use of these equations to identify individuals at risk of developing chronic kidney disease will improve clinical care and patient outcomes.
  • Nene, Vishvanath, et al. (författare)
  • Genome sequence of Aedes aegypti, a major arbovirus vector.
  • 2007
  • Ingår i: Science (New York, N.Y.). - 1095-9203. ; 316:5832, s. 1718-23
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
  • Nikolaitchouk, Natalia, 1967-, et al. (författare)
  • Lactobacillus coleohominis sp. nov., isolated from human sources.
  • 2001
  • Ingår i: International journal of systematic and evolutionary microbiology. - 1466-5026. ; 51:Pt 6, s. 2081-5
  • Tidskriftsartikel (refereegranskat)abstract
    • Four strains of a hitherto unrecognized gram-positive, catalase-negative, facultatively anaerobic, rod-shaped bacterium isolated from human sources were characterized using phenotypic and molecular taxonomic methods. Comparative 16S rRNA gene sequencing demonstrated that the bacterium represents a new subline within the Lactobacillus casei/Pediococcus rRNA group of the genus Lactobacillus. The unknown bacterium was readily distinguished from all other described Lactobacillus species and related taxa by biochemical tests and electrophoretic analysis of whole-cell proteins. On the basis of phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Lactobacillus coleohominis sp. nov. The type strain of Lactobacillus coleohominis is CCUG 44007T (= CIP 106820T).
  • Nikpay, Majid, et al. (författare)
  • A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
  • 2015
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 47:10, s. 1121-1130
  • Tidskriftsartikel (refereegranskat)abstract
    • Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of similar to 185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
  • Nova, Isabella, et al. (författare)
  • Influence of the substrate properties on the performances of NH3-SCR monolithic catalysts for the aftertreatment of diesel exhaust: an experimental and modeling study
  • 2011
  • Ingår i: Industrial & Engineering Chemistry Research. - 1520-5045 .- 0888-5885. ; 50:1, s. 299-309
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of structural and geometrical characteristics of wash-coated monolith catalysts on the NO-NO2/NH3 selective catalytic reduction (SCR) activity were experimentally investigated over the same Cu-exchanged zeolite system coated onto honeycomb cordierite substrates with different cell densities, lengths, washcoat loads, and channel shapes. A stacked configuration was also tested. Contrary to previous reports, it was found that both interphase and intraphase diffusional limitations appreciably affected the deNOx efficiency at intermediate to high temperatures, whereas entrance effects did not play a noticeable role in enhancing the NOx conversion. A two-phase 1D+1D dynamic mathematical model of SCR monolithic converters, which explicitly accounts for both gas/solid and intraporous mass-transfer resistances, successfully predicted all of the observed effects using a single set of rate parameters estimated from intrinsic kinetic runs performed over the same catalyst in powdered form, under diffusion-free conditions.
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