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561.
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566.
  • Pal, S., et al. (författare)
  • Characteristics of potential fibre Bragg grating sensor-based devices at elevated temperatures
  • 2003
  • Ingår i: Measurement science and technology. - 0957-0233. ; 14:7, s. 1131-1136
  • Tidskriftsartikel (refereegranskat)abstract
    • Fibre Bragg gratings (FBGs) of type I and IIA were fabricated in Ge-doped and B-Ge co-doped fibres using a 248 nm excimer laser and their performance characteristics were tested and compared with those of a chemical composition grating (CCG), written in a fluorine-germanium doped fibre, over a wide range of temperatures. Long-term testing (more than 600 h) involving a series of step-wise incremental temperature changes shows for the first time the potential of FBGs for high temperature measurement applications (up to and beyond 1100 degreesC), this depending on the type of FBG involved and the material and composition of the substrate fibre (the CCG was observed to be the most durable at very high temperatures). These gratings are likely to be useful for the simultaneous measurement of strain and temperature over these higher temperature ranges.
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567.
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569.
  • Peden, John F., et al. (författare)
  • A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
  • 2011
  • Ingår i: Nature genetics. - 1546-1718. ; 43:4, s. 339-U89
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
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