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  • Collins, J, et al. (författare)
  • Unintegrated parton density functions
  • 2005
  • Ingår i: HERA and the LHC,CERN, Geneva, Switzerland,2004-03-01. - CERN.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • An overview on activities to determine unintegrated parton density functions is given and the concept and need for unintegrated PDFs is discussed. It is also argued that it is important to reformulate perturbative QCD results in terms of fully unintegrated parton densities, differential in all components of the parton momentum. Also the need for non-linear BFKL evolution is discussed and results using the BK equation supplemented by DGLAP corrections at short distances is reviewed. Finally the use unintegrated generalized parton distributions for hard diffractive processes is discussed.
  • Collins, Lucy M, et al. (författare)
  • A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease
  • 2014
  • Ingår i: BMC Neurology. - BioMed Central (BMC). - 1471-2377. ; 14
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Current clinical assessments of motor function in Huntington's Disease (HD) rely on subjective ratings such as the Unified Huntington's Disease Rating scale (UHDRS). The ability to track disease progression using simple, objective, inexpensive, and robust measures would be beneficial.METHODS: One objective measure of motor performance is hand-tapping. Over the last 14 years we have routinely collected, using a simple device, the number of taps made by the right and left hand over 30 seconds in HD patients attending our NHS clinics.RESULTS: Here we report on a longitudinal cohort of 237 patients, which includes patients at all stages of the disease on a wide range of drug therapies. Hand tapping in these patients declines linearly at a rate of 5.1 taps per year (p < 0.0001; 95% CI = 3.8 to 6.3 taps), and for each additional year of age patients could perform 0.9 fewer taps (main effect of age: p = 0.0007; 95% CI = 0.4 to 1.4). Individual trajectories can vary widely around this average rate of decline, and much of this variation could be attributed to CAG repeat length. Genotype information was available for a subset of 151 patients, and for each additional repeat, patients could perform 5.6 fewer taps (p < 0.0001; 95% CI = 3.3 to 8.0 taps), and progressed at a faster rate of 0.45 fewer taps per year (CAG by time interaction: p = 0.008; 95% CI = 0.12 to 0.78 taps). In addition, for each unit decrease in Total Functional Capacity (TFC) within individuals, the number of taps decreased by 6.3 (95% CI = 5.4 to 7.1, p < 0.0001).CONCLUSIONS: Hand tapping is a simple, robust, and reliable marker of disease progression. As such, this simple motor task could be a useful tool by which to assess disease progression as well therapies designed to slow it down.
  • Collins, Lucy M., et al. (författare)
  • Dermal fibroblasts from patients with Parkinson's disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations
  • 2018
  • Ingår i: F1000Research. - F1000 Research Ltd.. - 2046-1402. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Recently, the development of Parkinson's disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. Methods: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. Results: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase) activity, whilst patients with PD and GBA mutations have a selective deficit in GCase enzyme activity and impaired autophagic flux. Conclusions: This data suggests that only PD patients with a GBA mutation have altered GCase activity and autophagy, which may explain their more rapid clinical progression.
  • Collins, Lucy M, et al. (författare)
  • Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease
  • 2015
  • Ingår i: PLoS Currents. - Public Library of Science. - 2157-3999. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.
  • Collins, Max, et al. (författare)
  • A constant power capacitor charging structure for flicker mitigation in high power long pulse klystron modulators
  • 2018
  • Ingår i: 21st IEEE International Conference on Pulsed Power, PPC 2017,Brighton, United Kingdom,2017-06-18 - 2017-06-22. - Institute of Electrical and Electronics Engineers Inc..
  • Konferensbidrag (refereegranskat)abstract
    • In order to generate high voltage high pulsed power, klystron modulators necessarily contain at least one capacitor bank charging structure supplying the energy to be released during the pulse. Conventional charging structures are based on AC/DC front-end units typically based on diode rectifiers combined with on/off controlled power charging structures as a second stage, producing prohibitive levels of grid flicker and harmonic contents on the AC grid side while operating at suboptimal power factor; problems usually corrected by both costly and spacious external grid compensators. Today, the increased demand on both accelerator peak power and pulse length (translating into higher average power), in conjunction with stricter regulations and standards represent additional challenges also in modulators' design. An alternative method for capacitor bank charging, implying use of a combination of a grid connected Active Front End (AFE) and a DC/DC buck converter is proposed. The AFE controls the AC line current to be sinusoidal (reducing harmonic content) and in phase with the AC line voltage (minimizing reactive power). The DC/DC converter is regulated in current mode for instantaneous constant power charging by measuring capacitor bank voltage and adjusting the current reference to match the exact average power consumed by the load over a pulse repetition cycle, allowing in steady state for complete reduction of the grid flicker despite the heavily pulsed loads. This paper explains in detail the working principle behind the proposed power electronic structure and associated control methodology, and provides successful power quality results obtained both in simulation and from experiments carried out on a klystron modulator prototype delivering long pulses (3.5 ms), high voltage (115 kV), and high pulsed power (peak power > 2 MW).
  • Collins, M D, et al. (författare)
  • An unusual Streptococcus from human urine, Streptococcus urinalis sp. nov.
  • 2000
  • Ingår i: International journal of systematic and evolutionary microbiology. - 1466-5026. ; 50 Pt 3, s. 1173-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Biochemical, molecular chemical and molecular genetic studies were performed on an unknown Gram-positive, catalase-negative, chain-forming coccus isolated from the urine of a patient suffering from cystitis. Comparative 16S rRNA gene sequencing showed that the organism is a member of the 'pyogenic subgroup' of the genus Streptococcus and has a close affinity with Streptococcus pyogenes and Streptococcus canis. The unknown coccus was, however, readily distinguished from these species and other streptococci by biochemical tests and electrophoretic analysis of whole-cell proteins. Based on phenotypic and phylogenetic evidence, it is proposed that the unknown bacterium be classified as a new species of the genus Streptococcus, Streptococcus urinalis sp. nov. The type strain of Streptococcus urinalis is CCUG 41590T.
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