SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Dorronsoro Miren) "

Sökning: WFRF:(Dorronsoro Miren)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
181.
  • Wu, Xifeng, et al. (författare)
  • A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
  • 2012
  • Ingår i: Human Molecular Genetics. - 0964-6906. ; 21:2, s. 456-462
  • Tidskriftsartikel (refereegranskat)abstract
    • Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P = 6.07 x 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.
  •  
182.
  • Zamora-Ros, Raul, et al. (författare)
  • Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
  • 2017
  • Ingår i: International Journal of Cancer. - John Wiley & Sons. - 0020-7136. ; 140:8, s. 1836-1844
  • Tidskriftsartikel (refereegranskat)abstract
    • Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
  •  
183.
  • Zheng, Ju-Sheng, et al. (författare)
  • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : : A cross-sectional analysis in the EPIC-InterAct study
  • 2017
  • Ingår i: BMC Medicine. - BioMed Central. - 1741-7015. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (47)
Typ av publikation
tidskriftsartikel (183)
Typ av innehåll
refereegranskat (183)
Författare/redaktör
Dorronsoro, Miren (181)
Riboli, Elio (158)
Trichopoulou, Antoni ... (155)
Overvad, Kim (153)
Boeing, Heiner (151)
Tumino, Rosario (151)
visa fler...
Palli, Domenico (125)
Khaw, Kay-Tee (124)
Kaaks, Rudolf (119)
Tjonneland, Anne (119)
Vineis, Paolo (113)
Boutron-Ruault, Mari ... (109)
Panico, Salvatore (109)
Bueno-de-Mesquita, H ... (103)
Tjønneland, Anne (102)
Sánchez, Maria-José (95)
Clavel-Chapelon, Fra ... (89)
Barricarte, Aurelio (85)
Jenab, Mazda (84)
Weiderpass, Elisabet ... (76)
Peeters, Petra H (75)
Olsen, Anja (70)
Trichopoulos, Dimitr ... (70)
Ardanaz, Eva (65)
Lund, Eiliv (61)
Lagiou, Pagona (61)
Peeters, Petra H. M. (61)
González, Carlos A (56)
Key, Timothy J (55)
Krogh, Vittorio (51)
Quirós, J Ramón (51)
Wareham, Nick (50)
Norat, Teresa (48)
Ferrari, Pietro (48)
Travis, Ruth C (47)
Hallmans, Göran, (46)
Sacerdote, Carlotta (45)
Romieu, Isabelle (44)
Navarro, Carmen (44)
Mattiello, Amalia (43)
Skeie, Guri (41)
Aleksandrova, Krasim ... (40)
Fedirko, Veronika (38)
Rinaldi, Sabina (38)
Chirlaque, Maria-Dol ... (36)
Manjer, Jonas (36)
Bamia, Christina (36)
Slimani, Nadia (36)
Quiros, JR (35)
Agudo, Antonio (35)
visa färre...
Lärosäte
Umeå universitet (168)
Lunds universitet (129)
Karolinska Institutet (89)
Göteborgs universitet (17)
Stockholms universitet (6)
Uppsala universitet (4)
visa fler...
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (183)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (174)
Lantbruksvetenskap (4)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy