SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Ehrnström Roy) "

Sökning: WFRF:(Ehrnström Roy)

  • Resultat 11-20 av 36
  • Föregående 1[2]34Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Ceder, Jens, et al. (författare)
  • The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate.
  • 2008
  • Ingår i: European Urology. - : Elsevier. - 1873-7560. ; 53:3, s. 524-532
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Questions regarding the cell source and mechanisms in the initiation and progression of prostate cancer are today still open for debate. Indeed, our knowledge regarding prostate cell regulation, self-renewal, and cytodifferentiation is presently rather limited. In this study, we investigated these processes in the normal adult human prostate. METHODS: Dynamic expression patterns in prostate stem/progenitor cells, intermediate/transit-amplifying cells, and cell lineages were immunohistochemically identified in an in situ explant renewal model of the human normal/benign adult prostate (n=6). RESULTS: Cells with a basal phenotype proliferated significantly in explant cultures, whereas luminal cells went into apoptosis. Results further show down-regulation in tissue cultures of the basal and hypothetical stem cell marker Bcl-2 in the majority of cells, except in rare putative epithelial stem cells. Investigation of established (AC133) and novel candidate prostate stem/progenitor markers, including the cell surface receptor tyrosine kinase KIT and its ligand stem cell factor (SCF), showed that these rare epithelial cells are AC133(+)/CD133(low)/Bcl-2(high)/cytokeratin(+)/vimentin(-)/KIT(low)/SCF(low). In addition, we report on a stromal population that expresses the mesenchymal marker vimentin and that is AC133(-)/CD133(high)/Bcl-2(-)/cytokeratin(-)/KIT(high)/SCF(high). CONCLUSIONS: We provide evidence for epithelial renewal in response to tissue culture and for basal and epithelial stem/progenitor cell recruitment leading to an expansion of an intermediate luminal precursor phenotype. Data further suggest that SCF regulates prostate epithelial stem/progenitor cells in an autocrine manner and that all or a subset of the identified novel stromal phenotype represents prostate stromal progenitor cells or interstitial pacemaker cells or both.
  •  
12.
  •  
13.
  • Don-Doncow, Nicholas, et al. (författare)
  • Expression of STAT3 in Prostate Cancer Metastases
  • Ingår i: European Urology. - : Elsevier. - 0302-2838. ; 71:3, s. 313-316
  • Tidskriftsartikel (refereegranskat)abstract
    • STAT3 and its upstream activator IL6R have been implicated in the progression of prostate cancer and are possible future therapeutic targets. We analyzed 223 metastatic samples from rapid autopsies of 71 patients who had died of castration-resistant prostate cancer (CRPC) to study protein and gene expression of pSTAT3 and IL6R. Immunohistochemical analysis revealed that 95% of metastases were positive for pSTAT3 and IL6R, with varying expression levels. Bone metastases showed significantly higher expression of both pSTAT3 and IL6R in comparison to lymph node and visceral metastases. STAT3 mRNA levels were significantly higher in bone than in lymph node and visceral metastases, whereas no significant difference in IL6R mRNA expression was observed. Our study strongly supports the suggested view of targeting STAT3 as a therapeutic option in patients with metastatic CRPC. Patient summary We studied the levels of two proteins (pSTAT3 and IL6R) in metastases from patients who died from castration-resistant prostate cancer. We found high levels of pSTAT3and IL6R in bone metastases, suggesting that these proteins could be used as targets for new anticancer drugs.
  •  
14.
  • Egevad, Lars, et al. (författare)
  • Primary seminal vesicle carcinoma detected at transurethral resection of prostate
  • 2007
  • Ingår i: Urology. - : Elsevier. - 1527-9995. ; 69:4
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a case of primary seminal vesicle carcinoma detected at transurethral resection. The clinical presentation, radiologic findings, and pathologic features of these tumors are reviewed. Grossly, seminal vesicle carcinoma is poorly circumscribed and solid or solid/cystic and may be misinterpreted as an abscess or hemorrhage on radiologic examination. Although a definitive diagnosis often cannot be given until after complete resection, we describe the findings indicative of seminal vesicle origin, including papillary histologic architecture, sometimes with mucinous differentiation, and a characteristic immunophenotype positive for CA-125 and cytokeratin 7, but negative for prostate-specific antigen and cytokeratin 20. UROLOGY 69: 778.e11-78.e13, 2007.
  •  
15.
  • Egevad, Lars, et al. (författare)
  • Urachal signet-cell adenocarcinoma
  • 2009
  • Ingår i: Scandinavian Journal of Urology and Nephrology. - : Taylor & Francis. - 0036-5599. ; 43:1, s. 88-91
  • Tidskriftsartikel (refereegranskat)abstract
    • This report presents two cases of urachal signet-cell adenocarcinoma (USCA). Two men, aged 53 and 51 years, presented with haematuria. Cystoscopy showed tumours in the dome of the bladder and transurethral resection revealed signet ring cell carcinoma. They both underwent cystoprostatectomy but died of metastatic disease after 14 and 26 months. USCA is a very rare tumour with poor prognosis. Only 25 cases have been reported. The tumours have a specific gross and microscopic morphology but must be distinguished from metastases of signet ring cell originating from other sites. Immunohistochemistry is helpful for the determination of the primary site.
  •  
16.
  • Ehrnström, Roy, et al. (författare)
  • An experimental study of gastric stump carcinoma in Wistar rats
  • 1995
  • Ingår i: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - : John Wiley and Sons Inc.. - 1600-0463. ; 103:12, s. 878-884
  • Tidskriftsartikel (refereegranskat)abstract
    • The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump carcinoma in rats without the addition of exogenous carcinogens. The aim of this study was: 1) to find the incidence of gastric carcinoma in rats subjected to BII resection and followed for 10 months, and 2) to examine if acetic acid, a common dietary factor, could influence the development of gastric carcinoma. Amongst BII-operated male Wistar rats, infiltrating carcinoma was found in 5/20 on a normal diet and in 5/24 exposed to acetic acid (NS). Benign mucosal changes were seen in 12/20 and 16/24 respectively (NS). With the exception of a profound inflammation in one sham-operated animal, no mucosal pathological changes were found in 24 sham-operated and 24 control animals where no operation was performed.
  •  
17.
  • Ehrnström, Roy (författare)
  • Carbonate Ions and Gastric Cancer
  • 2007
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • Nearly one million new cases of gastric cancer are diagnosed annually throughout the world. Even though the incidence has fallen dramatically in recent decades, this disease is still the second leading cause of cancer death in a global perspective. The geographic distribution of gastric cancer varies markedly, with the highest rates in Asian countries such as Japan, Korea, and China. This variation is presumably associated with modifiable risk factors, primarily H. pylori infection and diet, which have dominated the debate on this topic for more than a decade. The incidence of spontaneous gastric cancer is extremely low in rats, which has led to testing of different experimental models in attempts to generate gastric tumors in these animals. In the first study underlying this thesis, rats were subjected to gastric resection to generate duodenogastric reflux (DGR) and subsequent development of gastric adenocarcinomas. The effects of various food supplements on the incidence of cancer were studied using a total of 256 male Wistar rats. Surprisingly, in the first set of experiments in the second study, ingestion of food supplemented with calcium carbonate more than tripled the incidence of carcinomas (61%) compared to controls (17%). In a second set of experiments, calcium ions were switched to sodium ions, which revealed that carbonate ions caused the remarkable increase in cancer in the rats given an altered diet (54%, compared to 12% for controls). Both experimental and clinical studies have shown that DGR is associated with the development of gastric cancer. It has also been found that pancreaticoduodenal juice is responsible for the neoplastic formation, and that such fluid is especially rich in carbonate ions. The final study examined non-transformed mucosa in a rat model of gastric cancer to determine expression of COX-2 and ODC as markers of tumor promotion and to measure production of Ki67 as an indication of cell proliferation. This was done to assess the effect of carbonate ions on gastric tumorigenesis. The results indicated that the gastric resection per se increased COX-2 expression and significantly augmented cell proliferation. Dietary supplementation of carbonate ions did not further enhance the levels of COX-2. However, in the resected animals, carbonate-supplemented food led to elevated expression of ODC and a further increase in cell proliferation in the non-transformed mucosa. In conclusion, an environment entailing persistent chronic inflammation and increased levels of COX-2, induced by either duodenogastric reflux or a factor such as H. pylori infection, increases the risk of malignant transformation. Moreover, extra carbonate intake raises the levels of ODC in the gastric mucosa in a COX-2-dependent manner, which magnifies the proliferative drive and results in an even higher risk of gastric carcinoma.
  •  
18.
  •  
19.
  •  
20.
  • Förnvik, Daniel, et al. (författare)
  • No evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression.
  • 2013
  • Ingår i: Breast Cancer Research and Treatment. - : Springer. - 1573-7217. ; 141:2, s. 187-195
  • Tidskriftsartikel (refereegranskat)abstract
    • This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa (range, 1.0-22.5 kPa) and the average mean breast pressure 3.4 ± 1.6 kPa (range, 1.5-7.1 kPa) was statistically significant (p < 0.001), confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm (range, 9-30 mm). Four subjects (17 %) were CTC positive before compression and two of these (8 %) were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm(2) (range of the longest diameter, 5-12 μm). The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 36
  • Föregående 1[2]34Nästa
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy