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  • Kahn, Joel S., et al. (författare)
  • Anthropology and Modernity1/Comments/Reply
  • 2001
  • Ingår i: Current Anthropology. ; 42:5
  • Tidskriftsartikel (refereegranskat)abstract
    •   Against those who have taken anthropologists to task for flirting with the "meta-narratives" of modernity, this article argues that it is incumbent on them to engage with both modernity and modernist narratives far more directly and explicitly than in the past. This holds even, or especially, for those who, in positing a notion of multiple modernities, have managed to hold modernist narrative at arm’s length, neglecting the potential fruitfulness of juxtaposing Western and non-Western experiences of what Habermas has called the project of modernity. The encounter between anthropology and modernity is generated on the one hand by changes in the lives of the subjects of ethnographic research, but the fact of these changes raises more searching questions about whether ethnographers ever studied genuinely premodern peoples and cultures. The reflexive imperative, moreover, confirms the need to recognize anthropology’s own modernist origins. Finally it is argued that it is critical modernist theory in the Hegel-Marx-Weber tradition that is the most pertinent to the ethnographic encounter and that the exercise of bringing together critical theory and ethnographic knowledge, while conflictual, produces fruitful results for both sides. [PUBLICATION ABSTRACT]
  • Niska-Blakie, Joanna, et al. (författare)
  • Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
  • Ingår i: Cellular and Molecular Life Sciences. - : Birkhäuser Verlag. - 1420-682X.
  • Tidskriftsartikel (refereegranskat)abstract
    • SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients remain largely asymptomatic despite high levels of glutarate in the urine. To study the disease mechanism, we generated SugctKO mice and uncovered imbalanced lipid and acylcarnitine metabolism in kidney in addition to changes in the gut microbiome. After SugctKO mice were treated with antibiotics, metabolites were comparable to WT, indicating that the microbiome affects metabolism in SugctKO mice. SUGCT loss of function contributes to gut microbiota dysbiosis, leading to age-dependent pathological changes in kidney, liver, and adipose tissue. This is associated with an obesity-related phenotype that is accompanied by lipid accumulation in kidney and liver, as well as “crown-like” structures in adipocytes. Furthermore, we show that the SugctKO kidney pathology is accelerated and exacerbated by a high-lysine diet. Our study highlights the importance of non-essential genes with no readily detectable early phenotype, but with substantial contributions to the development of age-related pathologies, which result from an interplay between genetic background, microbiome, and diet in the health of mammals.
  • Pongpairoj, Korbkarn, et al. (författare)
  • Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy
  • Ingår i: Dermatitis. - : Lippincott Williams & Wilkins. - 1710-3568. ; 27:5, s. 248-258
  • Forskningsöversikt (refereegranskat)abstract
    • The International Contact Dermatitis Research Group proposes a classification for the clinical presentation of contact allergy. The classification is based primarily on the mode of clinical presentation. The categories are direct exposure/contact dermatitis, mimicking or exacerbation of preexisting eczema, multifactorial dermatitis including allergic contact dermatitis, by proxy, mimicking angioedema, airborne contact dermatitis, photo-induced contact dermatitis, systemic contact dermatitis, noneczematous contact dermatitis, contact urticaria, protein contact dermatitis, respiratory/mucosal symptoms, oral contact dermatitis, erythroderma/exfoliative dermatitis, minor forms of presentation, and extracutaneous manifestations.
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