SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Isaacs Sarah) "

Sökning: WFRF:(Isaacs Sarah)

  • Resultat 51-55 av 55
  • Föregående 12345[6]
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
51.
  • Ried, Janina S., et al. (författare)
  • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
  • 2016
  • Ingår i: Nature Communications. - Nature Publishing Group. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
52.
  • Shungin, Dmitry, et al. (författare)
  • New genetic loci link adipose and insulin biology to body fat distribution.
  • 2015
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 518:7538, s. 187-378
  • Tidskriftsartikel (refereegranskat)abstract
    • Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
  •  
53.
  • Siddiq, Afshan, et al. (författare)
  • A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
  • 2012
  • Ingår i: Human Molecular Genetics. - 0964-6906. ; 21:24, s. 5373-5384
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P 1 10(-5) in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR 1.16; P 1.1 10(8)) but showed a weaker association with overall breast cancer (OR 1.08, P 1.3 10(6)) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR 1.01, P 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR 1.12; P 1.1 10(9)), and with both ER-positive (OR 1.09; P 1.5 10(5)) and ER-negative (OR 1.16, P 2.5 10(7)) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci.
  •  
54.
  • Tragante, Vinicius, et al. (författare)
  • Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
  • 2014
  • Ingår i: American Journal of Human Genetics. - Cell Press. - 0002-9297. ; 94:3, s. 349-360
  • Tidskriftsartikel (refereegranskat)abstract
    • Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.
  •  
55.
  • Willer, Cristen J., et al. (författare)
  • Discovery and refinement of loci associated with lipid levels
  • 2013
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
  • Tidskriftsartikel (refereegranskat)abstract
    • Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P &lt; 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 51-55 av 55
  • Föregående 12345[6]
Åtkomst
fritt online (7)
Typ av publikation
tidskriftsartikel (54)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (53)
övrigt vetenskapligt (2)
Författare/redaktör
Isaacs, Aaron (27)
Van Duijn, Cornelia ... (22)
Hayward, Caroline (22)
Campbell, Harry (22)
Rudan, Igor (22)
Wilson, James F. (22)
visa fler...
Wild, Sarah H. (21)
Pramstaller, Peter P ... (21)
Hofman, Albert, (20)
Uitterlinden, Andre ... (20)
Oostra, Ben A. (20)
Wiklund, Fredrik (19)
Xu, Jianfeng (18)
Hicks, Andrew A. (18)
Wiley, Kathleen E (18)
Gyllensten, Ulf, (17)
Grönberg, Henrik (17)
Wright, Alan F. (17)
Isaacs, Sarah D (17)
Chasman, Daniel I., (16)
Polasek, Ozren (16)
Vitart, Veronique (16)
Gronberg, H, (15)
Gudnason, Vilmundur, (15)
Johansson, Åsa, (15)
Gieger, Christian (15)
Rivadeneira, Fernand ... (15)
Shuldiner, Alan R. (15)
Tanaka, Toshiko (15)
Isaacs, William B (15)
Ferrucci, Luigi, (14)
Esko, Tonu (14)
Harris, Tamara B. (14)
Walsh, Patrick C (14)
Ridker, Paul M., (13)
Prokopenko, Inga (13)
Boerwinkle, Eric (13)
Metspalu, Andres (13)
O'Connell, Jeffrey R ... (13)
Vollenweider, Peter, (13)
Illig, Thomas (12)
Munroe, Patricia B. (12)
Nolte, Ilja M (12)
Pattaro, Cristian (12)
Teumer, Alexander, (11)
Psaty, Bruce M., (11)
Jarvelin, Marjo-Riit ... (11)
Kolcic, Ivana (11)
Loos, Ruth J. F. (11)
Liu, Yongmei (11)
visa färre...
Lärosäte
Karolinska Institutet (32)
Uppsala universitet (27)
Umeå universitet (25)
Lunds universitet (17)
Göteborgs universitet (9)
Sveriges Lantbruksuniversitet (3)
visa fler...
Högskolan Dalarna (3)
Örebro universitet (2)
Stockholms universitet (1)
Mälardalens högskola (1)
visa färre...
Språk
Engelska (55)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (42)
Naturvetenskap (6)
Lantbruksvetenskap (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy