SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(James Paul A.) ;srt2:(2010-2014)"

Sökning: WFRF:(James Paul A.) > (2010-2014)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
161.
  • van Diepen, Sean, et al. (författare)
  • Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction : insights from the APEX-AMI trial
  • 2012
  • Ingår i: Journal of Thrombosis and Thrombolysis. - 0929-5305 .- 1573-742X. ; 34:1, s. 106-113
  • Tidskriftsartikel (refereegranskat)abstract
    • Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch.
  •  
162.
  • van Diepen, Sean, et al. (författare)
  • Prognostic relevance of baseline pro- and anti-inflammatory markers in STEMI : An APEX AMI substudy
  • 2013
  • Ingår i: International Journal of Cardiology. - 0167-5273 .- 1874-1754. ; 168:3, s. 2127-2133
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Plaque rupture, acute ischemia, and necrosis in acute coronary syndromes are accompanied by concurrent pro-and anti-inflammatory cascades. Whether STEMI clinical prediction models can be improved with the addition of baseline inflammatory biomarkers remains unknown. Methods: In an APEX-AMI trial substudy, 772 patients had a panel of 9 inflammatory serum biomarkers, high sensitivity C reactive protein (hsCRP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measured at baseline after randomization. Baseline biomarkers were incorporated into a clinical prediction model for a composite of 90-day death, shock, or heart failure. Incremental prognostic value was assessed using Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI). Results: Individually, several biomarkers were independent predictors of clinical outcome: hsCRP (hazard ratio [HR] 1.12; 95% confidence interval [CI], 1.03-1.21; p=0.007, per doubling), NT-proBNP (HR 1.14; 95% CI, 1.06-1.23; p<0.001, per doubling), interleukin (IL)-6 (HR 1.26; 95% CI, 1.12-1.41; p<0.001, per doubling), and inducible protein-10 (IP-10) (HR 0.86; 95% CI, 0.76-0.98; p<0.025, per doubling). The addition of baseline NT-proBNP (NRI 8.6%, p=0.028; IDI 0.030, p<0.001) and IL-6 (NRI 8.8%, p=0.012; IDI 0.036, p<0.001) improved the clinical risk prediction model and the addition of hsCRP (NRI 6.5%, p=0.069; IDI 0.018, p=0.004) yielded minimal improvement. After incorporating NT-proBNP into the model, the remaining biomarkers added little additional predictive value. Conclusions: Multiple inflammatory biomarkers independently predicted 90-day death, shock or heart failure; however, they added little value to a clinical prediction model that included NT-proBNP. Future studies of inflammatory biomarkers in STEMI should report incremental value in a prediction model that includes NT-proBNP.
  •  
163.
  • Women and Gender in Ancient Religions : Interdisciplinary Approaches
  • 2010
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt)abstract
    • Following a scholarly conference given in honor of Adela Yarbro Collins, this collection of essays offers focused studies on the wide range of ways that women and gender contribute to the religious landscape of the ancient world. Experts in Greek and Roman religions, Early Christianity, Ancient Judaism, and Ancient Christianity engage in literary, social, historical, and cultural analysis of various ancient texts, inscriptions, social phenomena, and cultic activity. These studies continue the welcomed trend in scholarship that expands the social location of women in ancient Mediterranean religion to include the public sphere and consciousness. The result is an important and lively book that deepens the understanding of ancient religion as a whole. With contributions by:Patricia D. Ahearne-Kroll, Loveday Alexander, Mary Rose D'Angelo, Stephen J. Davis, Robert Doran, Radcliffe G. Edmonds III, Carin M. C. Green, Fritz Graf, Jan Willem van Henten, Paul A. Holloway, Annette B. Huizenga, Jeremy F. Hultin, Sarah Iles Johnston, James A. Kelhoffer, Judith L. Kovacs, Outi Lehtipuu, Matt Jackson-McCabe, Candida R. Moss, Christopher N. Mount, Susan E. Myers, Clare K. Rothschild, Turid Karlsen Seim.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (25)
Typ av publikation
tidskriftsartikel (153)
forskningsöversikt (4)
bokkapitel (3)
samlingsverk (redaktörskap) (2)
konferensbidrag (1)
Typ av innehåll
refereegranskat (154)
övrigt vetenskapligt (9)
Författare/redaktör
Hofman, Albert, (45)
Uitterlinden, Andre ... (39)
Van Duijn, Cornelia ... (35)
Boerwinkle, Eric (34)
Rudan, Igor (33)
Hayward, Caroline (32)
visa fler...
Wareham, Nicholas J. (31)
Prokopenko, Inga (31)
Campbell, Harry (31)
Gudnason, Vilmundur, (30)
Harris, Tamara B. (29)
Shuldiner, Alan R. (28)
Psaty, Bruce M., (27)
Gieger, Christian (27)
Ferrucci, Luigi, (26)
Khaw, Kay-Tee (25)
McCarthy, Mark I (25)
Salomaa, Veikko (25)
Johnson, Toby (25)
Illig, Thomas (25)
Boomsma, Dorret I., (24)
Boehnke, Michael (24)
Rivadeneira, Fernand ... (24)
Polasek, Ozren (24)
Wright, Alan F. (24)
Rotter, Jerome I., (23)
Deloukas, Panos (23)
Chasman, Daniel I., (23)
Willemsen, Gonneke (23)
Esko, Tonu (23)
Pramstaller, Peter P ... (23)
Watkins, Hugh (23)
Ridker, Paul M., (22)
Ingelsson, Erik (22)
Samani, Nilesh J. (22)
Wild, Sarah H. (22)
Collins, Francis S. (22)
Cupples, L. Adrienne (22)
Hottenga, Jouke-Jan, (21)
Langenberg, Claudia (21)
Mangino, Massimo (21)
Oostra, Ben A. (21)
Wichmann, H. Erich (21)
Jarvelin, Marjo-Riit ... (21)
Jackson, Anne U. (21)
Luan, Jian'an (21)
Thorleifsson, Gudmar (21)
Zhao, Jing Hua (21)
Vitart, Veronique (21)
Elliott, Paul (21)
visa färre...
Lärosäte
Uppsala universitet (89)
Lunds universitet (73)
Karolinska Institutet (60)
Göteborgs universitet (32)
Umeå universitet (32)
Stockholms universitet (11)
visa fler...
Linköpings universitet (4)
Linnéuniversitetet (4)
Högskolan Dalarna (4)
Kungliga Tekniska Högskolan (3)
Örebro universitet (2)
Mittuniversitetet (2)
Högskolan i Skövde (1)
visa färre...
Språk
Engelska (163)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (129)
Naturvetenskap (33)
Samhällsvetenskap (5)
Teknik (1)
Lantbruksvetenskap (1)
Humaniora (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy