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Sökning: WFRF:(Ludvigsson M. L.)

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91.
  • Svensson, Christian, et al. (författare)
  • Characteristics of airborne gold aggregates generated by spark discharge and high temperature evaporation furnace: Mass-mobility relationship and surface area
  • 2015
  • Ingår i: Journal of Aerosol Science. - Elsevier. - 0021-8502. ; 87, s. 38-52
  • Tidskriftsartikel (refereegranskat)abstract
    • The properties of gas-borne aggregates are important in nano-technology and for potential health effects. Gold aggregates from three generators (one commercial and one custom built spark discharge generator and one high-temperature furnace) have been characterized. The aggregate surface areas were determined using five approaches - based on aggregation theory and/or measured aggregate properties. The characterization included mass-mobility relationships, effective densities (assessed by an Aerosol Particles Mass analyzer), primary particle analysis (based on Transmission Electron Microscopy), as well as total mass and number concentration outputs. The relationships between mass and mobility are well described by power-law functions with exponents of 2.18-2.35. For all generators, the primary particles of the aggregates were fused together by a bridge with a diameter typically similar to 60-70% of the primary particle diameter (5-10 nm). The total mass outputs were 6.1-48.1 mg/m3 and the predicted surface area outputs in the range 0.9 x 10(-3)-17 x 10(-3) cm(2)/cm(3). The aggregate effective densities differed considerably between generators. The difference could partly be explained by the differences in primary particle diameter, but not fully. This in turn may be explained either by a varying primary particle size with aggregate size, or by that there are slight differences in the morphology of the aggregates from the generators. (C) 2015 The Authors. Published by Elsevier Ltd.
92.
  • Svensson, M., et al. (författare)
  • Antibodies to Influenza Virus A/H1N1 Hemagglutinin in Type 1 Diabetes Children Diagnosed Before, During and After the SWEDISH A(H1N1)pdm09 Vaccination Campaign 2009-2010
  • 2014
  • Ingår i: Scandinavian Journal of Immunology. - Wiley. - 0300-9475 .- 1365-3083. ; 79:2, s. 137-148
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We determined A/H1N1-hemagglutinin (HA) antibodies in relation to HLAD-Q genotypes and islet autoantibodies at clinical diagnosis in 1141 incident 0.7 to 18-year-old type 1 diabetes patients diagnosed April 2009-December 2010. Antibodies to S-35-methionine-labelled A/H1N1 hemagglutinin were determined in a radio-binding assay in patients diagnosed before (n = 325), during (n = 355) and after (n = 461) the October 2009-March 2010 Swedish A(H1N1) pdm09 vaccination campaign, along with HLA-DQ genotypes and autoantibodies against GAD, insulin, IA-2 and ZnT8 transporter. Before vaccination, 0.6% patients had A/H1N1-HA antibodies compared with 40% during and 27% after vaccination (P less than 0.0001). In children less than3 years of age, A/H1N1-HA antibodies were found only during vaccination. The frequency of A/H1N1-HA antibodies during vaccination decreased after vaccination among the 3 less than 6 (P = 0.006) and 13 less than 18 (P = 0.001), but not among the 6 less than 13-year-olds. HLA-DQ2/8 positive children less than3 years decreased from 54% (15/28) before and 68% (19/28) during, to 30% (9/30) after vaccination (P = 0.014). Regardless of age, DQ2/2; 2/X (n = 177) patients had lower frequency (P = 0.020) and levels (P = 0.042) of A/H1N1-HA antibodies compared with non-DQ2/2; 2/X (n = 964) patients. GADA frequency was 50% before, 60% during and 51% after vaccination (P = 0.009). ZnT8QA frequency increased from 30% before to 34% during and 41% after vaccination (P = 0.002). Our findings suggest that young (less than3 years) along with DQ2/2; 2/X patients were low responders to Pandemrix (R). As the proportion of DQ2/8 patients less than3 years of age decreased after vaccination and the frequencies of GADA and ZnT8QA were enhanced, it cannot be excluded that the vaccine affected clinical onset of type 1 diabetes.</p>
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  • Resultat 91-92 av 92
  • Föregående 1...456789[10]
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