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  • Wernicke, Brian, 1976-, et al. (författare)
  • Flow Dimensions at Swedish Construction Contractors
  • 2019
  • Ingår i: Lean Construction Journal. - Arlington, US : Lean Construction Institute. - 1555-1369 .- 1555-1369. ; 2019, s. 24-46
  • Tidskriftsartikel (refereegranskat)abstract
    • Research Question: How do different flow dimensions and their interrelations appear in Swedish construction settings?Purpose: To contribute to the ongoing discussion on flow in construction by providing empirical data to a proposed flow model and widening the current understanding within Lean Construction with theory from industrialized construction and operations management.Research Design: Transcriptions of nine in-depth interviews with managers at different Swedish contractors were utilized to identify different flow dimensions.Findings: Results show different patterns which describe contractors’ focus on different flow dimensions.Limitations: The study is performed in Swedish construction companies with limited generalizability to construction in general. Data collection based on interviews might struggle with objectivity and multi-case studies do not coincide with in-depth research in each single case.Implications: Different flow dimensions are relevant within construction contractors and should be addressed by either management activities or an operations strategy.Value for practitioners: Increased understanding of flow in construction based on empirical data enables management of different flow dimensions to evolve contractors’ operations strategies towards Lean Construction or industrialized construction.
  • Ran, Caroline (författare)
  • On genes involved in common neurological disorders : focus on Parkinson's disease
  • 2014
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • Parkinson’s disease and migraine are complex neurological disorders and it is likely that a combination of genetic risk factors are involved in the etiology of both these diseases. Papers in this thesis investigate candidate genes in the search of genetic risk factors contributing to disease. Genetic research on Parkinson’s disease is extensive. Therefore, genes belonging to certain groups of risk-genes that are particularly interesting with regard to their function were selected for investigation in relation to this disease. We have performed association analyses alongside with gene expression and behavioral studies. Genetic variations in genes encoding detoxifying enzymes and genes involved in cellular processes of cell protection and survival have received special focus. We have also studied genes involved in mitochondrial function and genes linked to rare forms of hereditary Parkinson’s disease. A more recent approach in genetic studies has been to investigate genes shown to associate with or have close to significant p-values in genome wide association studies. In line with this, we have investigated major histocompability complex class II DR alpha (HLA-DRA), a gene connected to the immune-response, in our well characterized Parkinson’s disease case-control material. Through genetic analysis we have found evidence supportive of paraoxonase (PON) 1 and 2, mitochondrial translation initiation factor 3 (MTIF3), nuclear factor erythroid 2-like 2 (NRF2) and glucocerebrosidase (GBA) being associated with Parkinson’s disease. One single nucleotide polymorphism (SNP) in PON1 was associated with decreased risk of disease, while the other three genes were found to harbor SNPs and mutations conferring increased risk of Parkinson’s disease. The SNP in MTIF3 represents an expression quantitative trait locus and the presence of the minor allele was accompanied by a decrease in mRNA levels. Mitochondrial Ras homolog family (MIRO) 1 and 2, v-akt murine thymoma viral oncogene homolog 1 (AKT1) and HLA-DRA were also investigated, and shown not to associate with disease in our material. In spite of the lack of association with AKT1, we discovered that Parkinson patients had lower AKT1 gene expression, which we interpreted as a consequence of the constituent pathological conditions. We also studied alcohol dehydrogenase (ADH) genes and leucine-rich repeat kinase 2 (LRRK2) in animal models of Parkinson’s disease. We discovered that Lrrk2 and α-synuclein were co-regulated in the rodent striatum and that the lack of dopamine itself did not seem to influence the expression of these genes. In contrast, we found that absence of ADH genes, which are not expressed in the brain, could influence dopamine-dependent behavior in mice. Taken together, we have found evidence of involvement of all the targeted pathways and familial PD genes, with the exception of the immunological gene HLA-DRA. Little is known about the genetic relationships that might cause or influence the risk of migraine. Therefore we aimed to validate previously published genetic findings using microarray data in a well characterized Swedish cohort. Our study supports the involvement of genetic factors in migraine. We analyzed SNPs in eight candidate genes for migraine and our data are in favor of one SNP in PR domain containing 16 (PRDM16) and one SNP in the proximity of metadherin (MTDH) as risk factors for migraine in Sweden.
  • Ehrenborg, Casimir, et al. (författare)
  • Fundamental bounds on MIMO antennas
  • Rapport (övrigt vetenskapligt)abstract
    • Antenna current optimization is often used to analyze the optimal perfor-mance of antennas. Antenna performance can be quantied in e.g., minimumQ-factor and maximal gain over Q-factor ratio. The performance of MIMOantennas is more involved and a single parameter is, in general, not sucientto quantify it. Here, the capacity of an idealized channel is used as the mainperformance quantity. An optimization problem in the current distributionfor optimal capacity, measured in spectral eciency, given a xed Q-factorand eciency is formulated as a semi-denite optimization problem. A modelorder reduction based on characteristic and energy modes is employed to im-prove the computational eciency. The bound is illustrated by solving theoptimization problem numerically for a rectangular plate.
  • Benthem, P., et al. (författare)
  • Aperture array development for future large radio telescopes
  • 2011
  • Ingår i: European Conference on Antennas and Propagation 2011, 11-15 April 2011, Rome.
  • Konferensbidrag (refereegranskat)abstract
    • We present the design of a phased array system for future radio telescopes. This includes a system overview and recent results of the designed and implemented system, the Electronic Multi-Beam Radio Astronomy Concept (EMBRACE). Furthermore, simulations with a full-EM antenna simulator, combined with measurements on actual hardware, will provide information for the next design step, the Aperture Array Verification System (AAVS). With AAVS, we will prove design readiness of this novel array technology.
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