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Sökning: WFRF:(Masters Colin L.)

  • Resultat 11-15 av 15
  • Föregående 1[2]
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11.
  • Schindler, Suzanne E., et al. (författare)
  • Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19
  • 2020
  • Ingår i: Journal of Alzheimer's disease : JAD. - : IOS Press. - 1387-2877. ; 76:1, s. 27-31
  • Tidskriftsartikel (refereegranskat)abstract
    • The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. Some issues to consider include structuring the visit workflow to minimize contacts and promote social distancing; screening and/or testing participants and staff for COVID-19; wearing masks and performing hand hygiene; and precautions for handling, storing, and analyzing biofluids. AD fluid biomarker research remains a vitally important public health priority and resuming studies requires appropriate safety procedures to protect research participants and staff.
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12.
  • Schubert, Walter, et al. (författare)
  • Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites
  • 1991
  • Ingår i: Brain Research. - 0006-8993 .- 1872-6240. ; 563:1-2, s. 184-194
  • Tidskriftsartikel (refereegranskat)abstract
    • We have recently shown that the amyloid beta A4 precursor protein (APP) is synthesized in neurons and undergoes fast axonal transport to synaptic sites [Koo et al., Proc. Natl. Acad. Sci. U.S.A., 87 (1990) 1561-1565]. Using immunofluorescence, laser confocal microscopy and immunoelectron microscopy with simultaneous detection of APP and synaptophysin, we now report a preferential localization of APP at synaptic sites of human and rat brain and at neuromuscular junctions. APP is further found on vesicular elements of neuronal perikarya, dendrites and axons. The synaptic localization of APP implies (1) a role of APP in physiological synaptic activity and (2) a potential and early impairment of central synapses when synaptic APP is converted to beta A4 amyloid during the pathological evolution of Alzheimer's disease and Down's syndrome.
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13.
  • Westermark, Per, et al. (författare)
  • A primer of amyloid nomenclature
  • 2007
  • Ingår i: Amyloid. - 1350-6129 .- 1744-2818. ; 14:3, s. 179-183
  • Tidskriftsartikel (refereegranskat)abstract
    • The increasing knowledge of the exact biochemical nature of the localized and systemic amyloid disorders has made a logical and easily understood nomenclature absolutely necessary. Such a nomenclature, biochemically based, has been used for several years but the current literature is still mixed up with many clinical and histochemically based designations from the time when amyloid in general was poorly understood. All amyloid types are today preferably named by their major fibril protein. This makes a simple and rational nomenclature for the increasing number of amyloid disorders known in humans and animals.
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  • Resultat 11-15 av 15
  • Föregående 1[2]
 
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