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  • Strömqvist, Björn, et al. (författare)
  • Ansiktsskydd for buklägesoperationer
  • 2001
  • Ingår i: Ortopediskt Magasin. - Svensk ortopedteknisk förening. - 0349-733X. ; :1, s. 18-18
  • Tidskriftsartikel (populärvet., debatt m.m.)
  • Ståhl, Fredrik, et al. (författare)
  • Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data
  • 2015
  • Ingår i: IFAC-PapersOnLine. - 28. - IFAC. ; 48, s. 715-720
  • Konferensbidrag (refereegranskat)abstract
    • To improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.
  • Ståhl, Fredrik, et al. (författare)
  • Predicting Nocturnal Hypoglycemia Using a Non-Parametric Insulin Action Model
  • 2015
  • Ingår i: IEEE International Conference on Systems, Man, and Cybernetics (SMC),City University of Hong Kong, China,2015-10-09 - 2015-10-12. - IEEE - Institute of Electrical and Electronics Engineers Inc..
  • Konferensbidrag (refereegranskat)abstract
    • Nocturnal hypoglycemia is a common and potentially very dangerous condition facing persons with insulin-treated diabetes. To reduce the risk of going low while sleeping, many patient wilfully elevate their glucose level before bedtime, thereby also eroding the conditions for a sound glucose control for the next day. Recent advances in sensor technology allow for real-time frequent monitoring of the glucose level, and the road map towards an artificial pancreas involves combining an insulin pump with such sensors. The first steps towards a more autonomous insulin pump have been taken by allowing the pump to suspend the insulin supply when a hypoglycemic episode is imminent. This feature relies on algorithms for predicting the nocturnal event. In this paper, we present a novel model for this purpose. In comparison to previous methods, a better trade-off between sensitivity and false alarm rate was achieved, as well as improved warning time.
  • Stålsby Lundborg, Cecilia, et al. (författare)
  • Antibiotic prescribing in outpatients : a 1-week diagnosis-prescribing study in 5 counties in Sweden.
  • 2002
  • Ingår i: Scand J Infect Dis. - 0036-5548. ; 34:6, s. 442-8
  • Tidskriftsartikel (refereegranskat)abstract
    • A diagnosis-antibiotic prescribing study initiated by the Swedish Strategic Programme for the Rational Use of Antimicrobial Agents and Surveillance of Resistance was performed in 5 counties in Sweden (total 1,290,000 inhabitants) during 1 week in November 2000. The aims of the study were to analyse diagnoses and antibiotics prescribed for outpatients and to appraise the feasibility of the data collection method. Physicians in primary care and departments of ENT, paediatrics and infectious diseases completed a questionnaire for each patient with an infectious disease complaint, including information about age, sex, diagnosis, diagnostic methods used and treatment. When an antibiotic was prescribed, the type and duration of treatment were noted. A total of 7,071 forms were returned, of which 7,029 included information on diagnosis; infections of the respiratory tract, urinary tract and the skin or soft tissues were responsible for 70%, 14% and 10% of the visits, respectively. Antibiotics were prescribed in 59% of all cases and phenoxymethylpenicillin was the most commonly prescribed antibiotic. Of the forms returned, 94% emanated from primary care centres. In conclusion, this study provides information on the treatment pattern associated with various diagnoses and the pattern of use of various antibiotics. Such a study is relatively simple to perform and entails only a small extra workload for the participants.
  • Svensson, Kristian, et al. (författare)
  • The paternal allele of the H19 gene is silenced in a stepwise manner duringearly mouse development: : the acetylation status of histones mya be involved in the generation of variegated expression patter
  • 1998
  • Ingår i: Development. - 0950-1991 .- 1477-9129. ; 125:1, s. 61-69
  • Tidskriftsartikel (refereegranskat)abstract
    • Transcriptional silencing can reflect heritable, epigenetic inactivation of genes, either singly or in groups, during the life-time of an organism. This phenomenon is exemplified by parent-of-origin-specific inactivation events (genomic imprinting) for a subset of mammalian autosomal genes, such as H19. Very little is known, however, about the timing and mechanism(s) of silencing of the paternal H19 allele during mouse development. Using a novel in situ approach, we present evidence that the silencing of the paternal H19 allele is progressive in the trophectodermal lineage during early mouse development and generates variegated expression patterns. The silencing process apparently involves recruitment of histone deacetylases since the mosaic paternal-specific H19 expression reappears in trichostatin A-treated mouse conceptuses, undergoing in vitro organogenesis. Moreover, the paternal H19 alleles of PatDup.d7 placentas, in which a region encompassing the H19 locus of chromosome 7 is bipaternally derived, partially escape the silencing process and are expressed in a variegated manner. We suggest that allele-specific silencing of H19 share some common features with chromatin-mediated silencing in position-effect variegation.
  • Thulin, Åsa, et al. (författare)
  • Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein
  • 2009
  • Ingår i: Molecular Cancer Research. - 1541-7786 .- 1557-3125. ; 7:11, s. 1792-1802
  • Tidskriftsartikel (refereegranskat)abstract
    • The angiogenesis inhibitor histidine-rich glycoprotein (HRG) constitutes one of several examples of molecules regulating both angiogenesis and hemostasis. The antiangiogenic properties of HRG are mediated via its proteolytically released histidine- and proline-rich (His/Pro-rich) domain.Using a combination of immunohistochemistry and massspectrometry, we here provide biochemical evidence for thepresence of a proteolytic peptide, corresponding to the antiangiogenic domain of HRG, in vivo in human tissue. This finding supports a role for HRG as an endogenous regulator of angiogenesis. Interestingly, the His/Pro-rich peptide bound to the vessel wall in tissue from cancer patients but not to the vasculature in tissue from healthy persons.Moreover, the His/Pro-rich peptide was found in close association with platelets. Relesate from in vitro–activated platelets promoted binding of the His/Pro-rich domain of HRG to endothelial cells, an effect mediated by Zn2+.Previous studies have shown that zinc-dependent bindingof the His/Pro-rich domain of HRG to heparan sulfate on endothelial cells is required for inhibition of angiogenesis.We describe a novel mechanism to increase the local concentration and activity of an angiogenesis inhibitor,which may reflect a host response to counteract angiogenesis during pathologic conditions. Our finding that tumor angiogenesis is elevated in HRG-deficient mice supports this conclusion.
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