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  • Carlson, Jonas, et al. (författare)
  • Classification of Electrocardiographic P-wave Morphology
  • 2001
  • Ingår i: IEEE Transactions on Biomedical Engineering. - IEEE - Institute of Electrical and Electronics Engineers Inc.. - 1558-2531. ; 48:4, s. 401-405
  • Tidskriftsartikel (refereegranskat)abstract
    • The atrial activity of the human heart is normally visible in the electrocardiogram as a P-wave. In patients with intermittent atrial fibrillation, a different P-wave morphology can sometimes be seen, indicating atrial conduction defects. The purpose of this study was to develop a method to discriminate between such P-waves and normal ones. 20 recordings of each type were used in a classification which, based on impulse response analysis of the P-wave and linear discrimination between various parameters, produced a correct classification in 37 of the 40 recordings (sensitivity 95%, specificity 90%)
  • Carlson, Jonas, et al. (författare)
  • Left atrial conduction along the coronary sinus during ectopic atrial tachycardia and atrial fibrillation: a study using correlation function analysis.
  • 2003
  • Ingår i: Journal of Cardiovascular Electrophysiology. - Wiley-Blackwell. - 1540-8167. ; 14:10 Suppl, s. 148-153
  • Tidskriftsartikel (refereegranskat)abstract
    • ntroduction: Correlation function analysis was applied to endocardial electrograms to investigate conduction patterns along the coronary sinus (CS) during sinus rhythm (SR) and atrial tachycardias. Methods and Results: Eighteen recordings were obtained from 14 patients suffering from supraventricular tachycardias. Five atrial fibrillation(AF) recordings were compared to 10 SR recordings and 3 ectopic atrial tachycardia (EAT) recordings. The maximum correlation coefficient was used to assess similarity between signals, i.e., if they originate from the samewavefront. The cumulative time delay, calculated as pairwise summation of interelectrode time delays was used as an indicator of activation sequence along CS. Method validation using SR showed right to left conduction with high correlations in 8 of 10 recordings indicating one single wavefront. EAT recordings showed consistent left to right conduction with left atrial foci and right to left with right atrial focus and lower correlations than SR. All 5 AFrecordings showed predominantly left to right conduction direction, also with correlations lower than SR.Conclusion: 1) Correlation function analysis can be used to assess agreement between signals and direction of activation spread. 2) Due to the position of CS, the results can be used to derive mechanisms of interatrial conduction. 3) Consistency in electrical activity propagation along CS iscommon in AF.
  • Carlsson, G, et al. (författare)
  • Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia
  • 2006
  • Ingår i: Journal of Periodontology. - 0022-3492. ; 77:4, s. 744-751
  • Tidskriftsartikel (refereegranskat)abstract
    • Patients with Kostmann syndrome (severe congenital neutropenia [SCN]) typically normalize their absolute neutrophil count (ANC) upon granulocyte colony-stimulating factor (G-CSF) therapy. However, although they no longer experience life-threatening bacterial infections, they frequently still have recurrent gingivitis and even severe periodontitis, often starting in early childhood. METHODS: We studied the periodontal disease in the four surviving patients belonging to the family originally described by Kostmann. Their odontological records, x-rays, color photos, bacterial cultures, serum antibodies to oral bacteria, and histopathological examinations were reviewed. The data were also correlated to previous investigations on their antibacterial peptides and molecular biology. RESULTS: Three patients had periodontal disease, despite normal ANC and professional dental care, and had neutrophils deficient in antibacterial peptides. One of these patients also had a heterozygous mutation in the neutrophil elastase gene, had severe periodontal disease and overgrowth of the periodontal pathogen Actinobacillus actinomycetemcomitans in the dental flora, and 15 permanent teeth had been extracted by the age of 27. One bone marrow-transplanted patient had no periodontal disease. CONCLUSIONS: Normalized ANC levels are not sufficient to maintain normal oral health in SCN patients, and because neutrophils are important for first-line defense and innate immunity, the deficiency of the antibacterial peptide LL-37 probably explains their chronic periodontal disease. Professional dental care is still important for SCN patients, despite treatment with G-CSF and normal ANC levels. Whether antibacterial peptides play a role in the pathogenesis of periodontitis in other patients remains to be elucidated.
  • Cescon, Marzia, et al. (författare)
  • Short-Term Diabetes Blood Glucose Prediction Based On Blood Glucose Measurements
  • 2009
  • Ingår i: 2nd Int. Conference on Advanced Technologies and Treatments for Diabetes 2009,2009-02-25.
  • Konferensbidrag (refereegranskat)abstract
    • Given current glucose value, amount and timing of insulin injections and food intake, is it possible to predict future blood glucose levels with a prediction error of ±20 mg/dL? In the current study an attempt is made to empirically model the glucose-insulin dynamic interplay and to provide model-based short-term predictors suitable for the purpose.
  • Christiansson, Rolf, et al. (författare)
  • Studier av sprängskador i Äspö-laboratoriet
  • 2005
  • Ingår i: Bergsprängningskommittén Diskussionsmöte BK 2005. - Bergsprängningskommittén. ; s. 139-152
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • En ny tunnel med 70 m längd byggdes på 450 m djup i Äspölaboratoriet 2003. Det ställdes speciella krav på begränsning av sprängskadezonens djup med hänsyn till planerade experiment.Tunneln drevs med galleri och bågformad låg pall för att minimera sprängskador i sulan. I huvuddelen av tunneln användes initieringsystemet Nonel MS och LP. I de tre sista salvorna av galleriet testades elektroniksprängkapslar. Skonsamhetsgraden för vägg och tak var normal med en tillåten skadezon på 0,3 m. Däremot tillämpades samma skonsamhetsgrad även för botten. I övrigt användes normal sprängteknik och normala sprängämnen som Dynotex 17 och Dynorex.Arbetet följdes noggrant genom dokumentation av utfört arbete. Vibrationsmätningar utfördes på nära håll samt på stort avstånd, 1,5 km från arbetsplatsen. Språng¬skador har undersökts genom sågning och sprickkartering.Föredraget kommer att presentera projektet, framförallt (1) erfarenheter från vibra¬tionsmätningar av samtliga sprängsalvor (noggrannheten i geofonmätningarna; totala antalet spränghål i salvorna; bomsalvor; avståndet från salvorna och geo¬logiska strukturer), (2) P-vågshastigheten i tunnelns närområde, (3) faktorer som påverkar utvecklingen av sprängskador, och (4) förslag på kontrollåtgärder som kan leda till att begränsa skadezonen i praktiskt tunnelarbete.
  • Dörk, Thilo, et al. (författare)
  • Two truncating variants in FANCC and breast cancer risk
  • 2019
  • Ingår i: Scientific Reports. - 2045-2322 .- 2045-2322. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95% CI 0.44-1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.
  • Ekberg, Olle, et al. (författare)
  • Autonomic nerve dysfunction in patients with bolus-specific esophageal dysmotility
  • 1995
  • Ingår i: Dysphagia. - Springer. - 1432-0460. ; 10:1, s. 44-48
  • Tidskriftsartikel (refereegranskat)abstract
    • The pathogenetic mechanisms causing esophageal dysmotility is not well understood. We examined 13 patients with solid bolus dysphagia in a radiologic barium study including the swallowing of a 14-mm tablet. In all 13 patients the tablet was caught in the proximal or midesophagus. In 8 patients, the entrapment was associated with symptoms (Group 1) whereas in 5 patients (Group 2), no symptoms were reported. All 13 patients together with a control group of 56 healthy, nondysphagic subjects were tested for autonomic nerve function. Autonomic nerve function tests included registration of electrocardiographic R-R interval variation during deep breathing test (E/I ratio), a test of parasympathetic, vagal, nerve function. The results showed that the E/I ratio was significantly lower in patients with symptoms of bolus-specific esophageal dysmotility (-2,19 [1.76]) (median [interquartile range]) compared with patients without symptoms (0.05 [2, 87], p = 0.0192) and controls (-0.25 [1.26], p = 0.0009). In conclusion, symptomatic bolus-specific esophageal dysmotility is associated with vagal nerve dysfunction.
  • Ekberg, Olle, et al. (författare)
  • Das pharyngoosophageale Segment
  • 1995
  • Ingår i: Radiologe. - Springer. - 0033-832X. ; 35:10, s. 689-692
  • Tidskriftsartikel (refereegranskat)abstract
    • The pharyngoesophageal segment (PES) is a striated muscular structure separating the relatively wide pharynx from the narrow cervical esophagus. There is a substantial axial and longitudinal asymmetry within the PES, as well as basal resting pressure that is substantially influenced by a variety of stimuli as well as deglutition.
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