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Sökning: WFRF:(Pedersen Nancy L.) > (2000-2004)

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  • Larsson, Mats, et al. (författare)
  • Genetic correlations among texture characteristics in the human iris
  • 2004
  • Ingår i: Molecular Vision. - 1090-0535 .- 1090-0535. ; 10, s. 821-831
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>PURPOSE:</p> <p>To estimate the magnitude of genetic correlations among five general textural characteristics of the human iris.</p> <p>METHODS:</p> <p>Color photographs of iris were available from 100 monozygotic and 99 dizygotic twin pairs. Comparative scales were constructed based on ratings of the subjects' left iris. To explore the genetic and environmental covariation among frequency of Fuchs' crypts, frequency of pigment dots, iris color, the extension, and distinction of Wolfflin nodules, and contraction furrows, a structural equation model with Cholesky decomposition was applied to variance-covariance matrices for monozygotic (MZ) and dizygotic (DZ) pairs.</p> <p>RESULTS:</p> <p>Significant genetic correlations fell between -0.22 and 0.44 and accounted almost entirely for the phenotypic correlations among the iris characteristics. No evidence for individual specific environmental effects in common to the characteristics was found.</p> <p>CONCLUSIONS:</p> <p>The modest genetic correlations indicate that there is little overlap in the genetic influence for these characteristics. Candidate genes with embryological and histological expression patterns in the eye could potentially influence the iris characteristics' variability.</p>
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26.
  • Larsson, Mats, et al. (författare)
  • Importance of genetic effects for characteristics of the human iris
  • 2003
  • Ingår i: Twin research. - 1369-0523 .- 2053-6003. ; 6:3, s. 192-200
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The relative importance of genetic influences (heritability) on five general textural quality characteristics of the human iris was assessed using sex and age limitation models. Colour photographs of irises were available from 100 monozygotic twin pairs, 99 dizygotic twin pairs, and 99 unrelated randomly paired age-matched German subjects. Comparative scales were constructed and two judges who were blind to zygosity independently rated five characteristic of the subjects' left iris. Inter-rater reliabilities were larger than .90 for all five scales. The heritabilities for the five iris characteristics ranged from .51-.90. No sex-specific genetic factors were found for the iris characteristics. Age-group differences in heritability were found for one of the five iris characteristics — "distinction of white dot rings". Heritability was greater for the older cohort (90%) than the younger (73%). The iris characteristics that showed the next highest additive-genetic effect were "contractional furrows" (78%) and "frequency of crypts" in the main stroma leaf (66%).</p>
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  • Resultat 21-29 av 29
  • Föregående 12[3]
 
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