Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Persson Fredrik) "

Sökning: WFRF:(Persson Fredrik)

Sortera/gruppera träfflistan
  • Johansson, Karl-Axel, et al. (författare)
  • The quality assurance process for the ARTSCAN head and neck study - a practical interactive approach for QA in 3DCRT and IMRT.
  • 2008
  • Ingår i: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 87:2, s. 290-299
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: This paper describes the quality assurance (QA) work performed in the Swedish multicenter ARTSCAN (Accelerated RadioTherapy of Squamous cell CArcinomas in the head and Neck) trial to guarantee high quality in a multicenter study which involved modern radiotherapy such as 3DCRT or IMRT. MATERIALS AND METHODS: The study was closed in June 2006 with 750 randomised patients. Radiation therapy-related data for every patient were sent by each participating centre to the QA office where all trial data were reviewed, analysed and stored. In case of any deviation from the protocol, an interactive process was started between the QA office and the local responsible clinician and/or physicist to increase the compliance to the protocol for future randomised patients. Meetings and workshops were held on a regular basis for discussions on various trial-related issues and for the QA office to report on updated results. RESULTS AND DISCUSSION: This review covers the 734 patients out of a total of 750 who had entered the study. Deviations early in the study were corrected so that the overall compliance to the protocol was very high. There were only negligible variations in doses and dose distributions to target volumes for each specific site and stage. The quality of the treatments was high. Furthermore, an extensive database of treatment parameters was accumulated for future dose-volume vs. endpoint evaluations. CONCLUSIONS: This comprehensive QA programme increased the probability to draw firm conclusions from our study and may serve as a concept for QA work in future radiotherapy trials where comparatively small effects are searched for in a heterogeneous tumour population.
  • Kallberg, Yvonne, et al. (författare)
  • Evolutionary Conservation of the Ribosomal Biogenesis Factor Rbm19/Mrd1 : Implications for Function
  • 2012
  • Ingår i: PLoS ONE. - 1932-6203 .- 1932-6203. ; 7:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Ribosome biogenesis in eukaryotes requires coordinated folding and assembly of a pre-rRNA into sequential pre-rRNA-protein complexes in which chemical modifications and RNA cleavages occur. These processes require many small nucleolar RNAs (snoRNAs) and proteins. Rbm19/Mrd1 is one such protein that is built from multiple RNA-binding domains (RBDs). We find that Rbm19/Mrd1 with five RBDs is present in all branches of the eukaryotic phylogenetic tree, except in animals and Choanoflagellates, that instead have a version with six RBDs and Microsporidia which have a minimal Rbm19/Mrd1 protein with four RBDs. Rbm19/Mrd1 therefore evolved as a multi-RBD protein very early in eukaryotes. The linkers between the RBDs have conserved properties; they are disordered, except for linker 3, and position the RBDs at conserved relative distances from each other. All but one of the RBDs have conserved properties for RNA-binding and each RBD has a specific consensus sequence and a conserved position in the protein, suggesting a functionally important modular design. The patterns of evolutionary conservation provide information for experimental analyses of the function of Rbm19/Mrd1. In vivo mutational analysis confirmed that a highly conserved loop 5-β4-strand in RBD6 is essential for function.
  • Nahlen Bose, Catarina, et al. (författare)
  • Patterns and the mediating role of avoidant coping style and illness perception on anxiety and depression in patients with chronic heart failure
  • 2016
  • Ingår i: Scandinavian Journal of Caring Sciences. - 0283-9318 .- 1471-6712. ; 30:4, s. 704-713
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Emotional distress in patients with chronic heart failure (CHF) predicts mortality, hospital readmission and quality of life. The patient's avoidant coping style and beliefs about the disease have been linked to emotional distress in CHF. However, the pattern and transmitting effects of these variables are indefinite.Aim: This study aimed to examine the links between and the potential mediating role of illness perceptions and avoidant coping style on depression and anxiety in patients with CHF.Method: Self-assessment data from 103 patients with CHF were subjected to path analysis in two hypothesised models. The outcome measures were coping styles, illness perception, anxiety and depression.Results: Avoidant coping had a direct adverse effect on anxiety and depression. The perception of symptom burden and personal control, significantly mediated the effect between avoidant coping and anxiety and depression.Conclusions: Avoidant coping style appears to influence not only emotional distress, but also a malignant symptom perception and low sense of control over the illness.
  • Pekar, Heidi, et al. (författare)
  • Fast, rugged and sensitive ultra high pressure liquid chromatography tandem mass spectrometry method for analysis of cyanotoxins in raw water and drinking water-First findings of anatoxins, cylindrospermopsins and microcystin variants in Swedish source waters and infiltration ponds
  • 2016
  • Ingår i: ; 1429, s. 265-276
  • Tidskriftsartikel (refereegranskat)abstract
    • Freshwater blooms of cyanobacteria (blue-green algae) in source waters are generally composed of several different strains with the capability to produce a variety of toxins. The major exposure routes for humans are direct contact with recreational waters and ingestion of drinking water not efficiently treated. The ultra high pressure liquid chromatography tandem mass spectrometry based analytical method presented here allows simultaneous analysis of 22 cyanotoxins from different toxin groups, including anatoxins, cylindrospermopsins, nodularin and microcystins in raw water and drinking water. The use of reference standards enables correct identification of toxins as well as precision of the quantification and due to matrix effects, recovery correction is required. The multi-toxin group method presented here, does not compromise sensitivity, despite the large number of analytes. The limit of quantification was set to 0.1 mu g/L for 75% of the cyanotoxins in drinking water and 0.5 mu g/L for all cyanotoxins in raw water, which is compliant with the WHO guidance value for microcystin-LR. The matrix effects experienced during analysis were reasonable for most analytes, considering the large volume injected into the mass spectrometer. The time of analysis, including lysing of cell bound toxins, is less than three hours. Furthermore, the method was tested in Swedish source waters and infiltration ponds resulting in evidence of presence of anatoxin, homo-anatoxin, cylindrospermopsin and several variants of microcystins for the first time in Sweden, proving its usefulness.
  • Persson, A. E., et al. (författare)
  • The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes
  • 2002
  • Ingår i: Photodermatology, Photoimmunology & Photomedicine. - 0905-4383 .- 1600-0781. ; 18:6, s. 287-293
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Sun exposure is accepted as the major risk factor for developing skin cancer, the most common cancer in the western world. Ultraviolet-B (UV-B) radiation is considered the causative agent, but recently several findings suggest a role also for ultraviolet-A (UV-A) radiation. Repeated suberythemal doses of ultraviolet-A1 (UV-A1) on healthy human skin induce an increase of p53 immunoreactive cells in epidermis, which may indicate cell cycle arrest and/or occurrence of p53 mutations. Methods: We have investigated the possible mutagenic effect of UV-A1 on skin by sequencing exons 4-11 and adjacent intron sequence of the p53 gene in immunoreactive single cells from three healthy individuals. Previously unexposed buttock skin was irradiated three times a week for 2 weeks with physiological fluences (40 J/cm(2)) of UV-A1. Punch biopsies were taken before and at different time-points after the exposure, and from these single p53 immunoreactive cells were isolated by using laser-assisted microdissection. Results: Three mutations - all being indicative of oxidative damage and most likely related to UV-A exposure were found among the 37 single cells from exposed skin, whereas no mutations were found in the 22 single cells taken before exposure. Conclusions: The findings indicate a mutagenic effect of low-dose UV-A1 on healthy human skin, which further demonstrates the importance of considering UV-A when taking protective measures against skin cancer.
  • Persson, Fredrik, et al. (författare)
  • 2017
  • Ingår i: 2017 WINTER SIMULATION CONFERENCE (WSC). - : IEEE. - 9781538634288 ; , s. 3768-3779
  • Konferensbidrag (refereegranskat)abstract
    • Safety stock calculations are difficult for products with intermittent demand, long production lead times, and high monetary values. Theoretically, forecasts can be used to reduce the need for safety stocks. A high precision forecast minimizes the need for safety stock and forecast evaluation measurements can be used to calculate the safety stock level. However, a more realistic determination of safety stock levels can he obtained by simulation. In this paper, simulation is used to model and experiment on a case with three end products in order to determine the relationship between safety stock levels and service levels. Also, a comparison is made with theoretically calculated safety stocks to see how well basic theoretical models for safety stock calculations fulfill the requirements of service level. The result is that simulation can provide a much more accurate determination of safety stock levels for intermittent demands than theoretical calculations.
  • Persson, M. Friederich, et al. (författare)
  • Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
  • 2012
  • Ingår i: Diabetologia. - : Springer Verlag (Germany). - 0012-186X .- 1432-0428. ; 55:5, s. 1535-1543
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims/hypothesis  Increased oxygen consumption results in kidney tissue hypoxia, which is proposed to contribute to the development of diabetic nephropathy. Oxidative stress causes increased oxygen consumption in type 1 diabetic kidneys, partly mediated by uncoupling protein-2 (UCP-2)-induced mitochondrial uncoupling. The present study investigates the role of UCP-2 and oxidative stress in mitochondrial oxygen consumption and kidney function in db/db mice as a model of type 2 diabetes. Methods  Mitochondrial oxygen consumption, glomerular filtration rate and proteinuria were investigated in db/db mice and corresponding controls with and without coenzyme Q10 (CoQ10) treatment.Results  Untreated db/db mice displayed mitochondrial uncoupling, manifested as glutamate-stimulated oxygen consumption (2.7 ± 0.1 vs 0.2 ± 0.1 pmol O2 s−1 [mg protein]−1), glomerular hyperfiltration (502 ± 26 vs 385 ± 3 μl/min), increased proteinuria (21 ± 2 vs 14 ± 1, μg/24 h), mitochondrial fragmentation (fragmentation score 2.4 ± 0.3 vs 0.7 ± 0.1) and size (1.6 ± 0.1 vs 1 ± 0.0 μm) compared with untreated controls. All alterations were prevented or reduced by CoQ10 treatment. Mitochondrial uncoupling was partly inhibited by the UCP inhibitor GDP (−1.1 ± 0.1 pmol O2 s−1 [mg protein]−1). UCP-2 protein levels were similar in untreated control and db/db mice (67 ± 9 vs 67 ± 4 optical density; OD) but were reduced in CoQ10 treated groups (43 ± 2 and 38 ± 7 OD).Conclusions/interpretation  db/db mice displayed oxidative stress-mediated activation of UCP-2, which resulted in mitochondrial uncoupling and increased oxygen consumption. CoQ10 prevented altered mitochondrial function and morphology, glomerular hyperfiltration and proteinuria in db/db mice, highlighting the role of mitochondria in the pathogenesis of diabetic nephropathy and the benefits of preventing increased oxidative stress.
  • Persson, M., et al. (författare)
  • Heavy Meromyosin Molecules Extending More Than 50 nm above Adsorbing Electronegative Surfaces
  • 2010
  • Ingår i: Langmuir. - : The American Chemical Society (ACS). - 1520-5827 .- 0743-7463. ; 26:12, s. 9927-9936
  • Tidskriftsartikel (refereegranskat)abstract
    • In the in vitro motility assay, actin filaments are propelled by surface-adsorbed myosin motors, or rather, myosin motor fragments such as heavy meromyosin (HMM). Recently, efforts have been made to develop actomyosin powered nanodevices on the basis of this assay but such developments are hampered by limited understanding of the HMM adsorption geometry. Therefore, we here investigate the HMM adsorption geometries on trimethylchlorosilane-[TMCS-] derivatized hydrophobic surfaces and on hydrophilic negatively charged surfaces (SiO2). The TMCS surface is of great relevance in fundamental studies of actomyosin and both surface substrates are important for the development of motor powered nanodevices. Whereas both the TMCS and SiO2 surfaces were nearly saturated with HMM (incubation at 120 mu g mL(-1)) there was little actin binding on SiO2 in the absence of ATP and no filament sliding in the presence of ATP. This contrasts with excellent actin-binding and motility on TMCS. Quartz crystal microbalance with dissipation (QCM-D) studies demonstrate a HMM layer with substantial protein mass up to 40 nm above the TMCS surface, considerably more than observed for myosin subfragment 1 (SI; 6 nm). Together with the excellent actin transportation on TMCS, this strongly suggests that HMM adsorbs to TMCS mainly via its most C-terminal tail part. Consistent with this idea, fluorescence interference contrast (FLIC) microscopy showed that actin filaments are held by HMM 38 +/- 2 nm above the TMCS-surface with the catalytic site, on averge, 20-30 nm above the surface. Viewed in a context with FLIC, QCM-D and TIRF results, the lack of actin motility and the limited actin binding on SiO2 shows that HMM adsorbs largely via the actin-binding region on this surface with the C-terminal coiled-coil tails extending > 50 nm into solution. The results and new insights from this study are of value, not only for the development of motor powered nanodevices but also for the interpretation of fundamental biophysical studies of actomyosin function and for the understanding of surface protein interactions in general.
  • Sundström, Johan, Professor, 1971-, et al. (författare)
  • Weight gain and blood pressure
  • 2020
  • Ingår i: ; 38:3, s. 387-394
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Although the causality of the obesity—hypertension association is established, the potential for prevention is not. We hypothesized that weight gain between early adulthood and mid-life is associated with higher mid-life blood pressure.METHODS: We investigated the hypothesis using a large contemporaneous population-based mid-life cohort of men and women aged 50-64 years. Recalled body weight at age 20 years was self-reported, and mid-life body weight and office blood pressures were measured in accordance with a detailed protocol.RESULTS: On average, men had gained 14.9 (95% CI 14.6-15.2) kg of weight, and women 14.6 (95% CI 14.4-14.9) kg, between age 20 years and the mid-life examination, corresponding to 0.40 (95% CI 0.39-0.41) kg/year for men and women. Both weight at age 20 years and weight at the mid-life examination were associated with mid-life blood pressures. On average, a 10 kg weight increase between age 20 years and mid-life was associated with 2.2 (95% CI 0.9-3.5) mmHg higher systolic and 1.7 (95% CI 0.9-2.5) mmHg higher diastolic mid-life blood pressure in men, and 3.2 (2.5-4.0) mmHg higher systolic and 2.4 (1.9-2.9) mmHg higher diastolic mid-life blood pressure in women. Mid-life weight was more closely associated than weight at age 20 years with mid-life blood pressure. For a given mid-life weight, blood pressure was higher in persons with higher weight gain from age 20 years.CONCLUSION: In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood.
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (276)
konferensbidrag (94)
rapport (41)
annan publikation (22)
bokkapitel (19)
doktorsavhandling (12)
visa fler...
forskningsöversikt (8)
licentiatavhandling (8)
recension (5)
bok (4)
proceedings (redaktörskap) (3)
samlingsverk (redaktörskap) (2)
patent (2)
konstnärligt arbete (1)
visa färre...
Typ av innehåll
refereegranskat (322)
övrigt vetenskapligt (145)
populärvet., debatt m.m. (29)
Persson, Fredrik (104)
Persson, Fredrik, 19 ... (31)
Palm, Fredrik (29)
Hansell, Peter (23)
Persson, Fredrik, 19 ... (22)
Tegenfeldt, Jonas O. (21)
visa fler...
Westerlund, Fredrik, ... (20)
Persson, Patrik (19)
Persson, F. (17)
Persson, Per (16)
Uhlén, Mathias (16)
Pontén, Fredrik (15)
Tegenfeldt, J. O. (15)
Persson, Fredrik, 19 ... (14)
Tegenfeldt, Jonas (13)
Stenman, Göran, 1953 (13)
Persson, Bengt (12)
Fritzsche, Joachim, ... (11)
Westerlund, Fredrik (11)
Nilsson, Peter (10)
Fritzsche, Joachim (10)
Hober, Sophia (9)
Asplund, Anna (9)
Kampf, Caroline (9)
Wester, Kenneth (9)
Modesti, M. (9)
Persson, Karin (9)
Kristensen, Anders (9)
Espinoza, Fredrik (9)
Karlsson, Fredrik (8)
Wilson, Christopher, ... (8)
Delsing, Per, 1959 (8)
Olsson, Fredrik (8)
Persson, B (8)
Persson, M (8)
Gustafsson, Fredrik (8)
Persson, Anja (8)
Nyberg, Lena, 1979 (8)
Nilsson, Fredrik (7)
Persson, H (7)
Sehlstedt-Persson, M ... (7)
Persson, Katrin (7)
Wernerus, Henrik (7)
Björling, Erik (7)
Persson, Mikael, 195 ... (7)
Edelvik, Fredrik, 19 ... (7)
Hedenus, Fredrik, 19 ... (7)
Persson, Martin, 197 ... (7)
Persson, Mats, 1954 (7)
Palm, Fredrik, 1973- (7)
visa färre...
Linköpings universitet (115)
Lunds universitet (102)
Uppsala universitet (100)
Chalmers tekniska högskola (69)
Göteborgs universitet (53)
Kungliga Tekniska Högskolan (35)
visa fler...
RISE (30)
Karolinska Institutet (19)
Umeå universitet (10)
Stockholms universitet (9)
Luleå tekniska universitet (8)
Linnéuniversitetet (8)
swepub_uni:mau_t (6)
Karlstads universitet (6)
Röda Korsets Högskola (6)
Mittuniversitetet (5)
Naturhistoriska riksmuseet (5)
Mälardalens högskola (4)
Örebro universitet (4)
Högskolan Dalarna (4)
Jönköping University (2)
Blekinge Tekniska Högskola (2)
Sveriges Lantbruksuniversitet (2)
Högskolan i Skövde (1)
Högskolan i Borås (1)
visa färre...
Engelska (413)
Svenska (80)
Odefinierat språk (2)
Tyska (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (111)
Medicin och hälsovetenskap (100)
Teknik (91)
Samhällsvetenskap (33)
Humaniora (30)
Lantbruksvetenskap (3)


pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy