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  • Prosek, Tomas, et al. (författare)
  • Relationship between corrosion performance and microstructure of Zn-AI and Zn-AI-Mg model alloys
  • 2015
  • Ingår i: European Corrosion Congress, EUROCORR 2015. - Austrian Society for Metallurgy and Materials (ASMET). - 9781510837379 ; s. 511-522
  • Konferensbidrag (refereegranskat)abstract
    • <p>Zn-5wt.%AI and Zn-3wt.%AI-2wt.%Mg model alloys were cast and heat treated in order to obtain specimens with distinct microstructure and identical chemical composition. The microstructure was characterized in detail using scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDX) and x-ray diffraction spectroscopy (XRD) to identify chemical composition, size and distribution of present phases. Mass loss of samples with different microstructure and identical chemical composition subjected to a cyclic corrosion test and a test under non-rinsing conditions differed by a factor of up to two. Some model alloys showed better corrosion performance compared to commercial coatings with similar composition tested in parallel. This indicates that microstructure modification can improve the corrosion performance of industrial zinc alloy coatings. The mechanism is discussed based on measurements of corrosion stability of individual phases, preferential corrosion, composition and stability of corrosion products, dc electrochemical characteristics and infrared absorption spectroscopy (IRRAS) experiments.</p>
  • Qaiser, Mahmood, 1981-, et al. (författare)
  • On the Fully Automatic Construction of a Realistic Head Model for EEG Source Localization
  • 2013
  • Ingår i: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. - 1557170X. ; s. 3331-3334
  • Konferensbidrag (refereegranskat)abstract
    • Accurate multi-tissue segmentation of magnetic resonance (MR) images is an essential first step in the construction of a realistic finite element head conductivity model (FEHCM) for electroencephalography (EEG) source localization. All of the segmentation approaches proposed to date for this purpose require manual intervention or correction and are thus laborious, time-consuming, and subjective. In this paper we propose and evaluate a fully automatic method based on a hierarchical segmentation approach (HSA) incorporating Bayesian-based adaptive mean-shift segmentation (BAMS). An evaluation of HSA-BAMS, as well as two reference methods, in terms of both segmentation accuracy and the source localization accuracy of the resulting FEHCM is also presented. The evaluation was performed using (i) synthetic 2D multi-modal MRI head data and synthetic EEG (generated for a prescribed source), and (ii) real 3D T1-weighted MRI head data and real EEG data (with expert determined source localization). Expert manual segmentation served as segmentation ground truth. The results show that HSA-BAMS outperforms the two reference methods and that it can be used as a surrogate for manual segmentation for the construction of a realistic FEHCM for EEG source localization.
  • Romu, Thobias, et al. (författare)
  • A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
  • 2016
  • Ingår i: Metabolism : Clinical and Experimental. - Elsevier. - 0026-0495 .- 1532-8600. ; 65:6, s. 926-934
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Objective</strong></p><p>To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.</p><p><strong>Design</strong></p><p>Randomized, open, parallel-group trial.</p><p><strong>Methods</strong></p><p>Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).</p><p><strong>Results</strong></p><p>Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 ± 199 kCal/24 h to 1795 ± 213 kCal/24 h, <em>p</em> = 0.047 cold-activated MR from 1900 ± 150 kCal/24 h to 1793 ± 215 kCal/24 h, <em>p</em> = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (<em>p</em> = 0.052). The difference between MR changes by the interventions between groups was statistically significant (<em>p</em> = 0.008 at room temperature, <em>p</em> = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥ 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 ± 0.015 l to 0.0216 ± 0.014 l, <em>p</em> = 0.049).</p><p><strong>Conclusions</strong></p><p>We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.</p>
  • Ruiz Pavón, Lorena, et al. (författare)
  • Arabidopsis ANTR1 is a thylakoid Na+-dependent phosphate transporter -functional characterization in Escherichia coli
  • 2008
  • Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 283:20, s. 13520-13527
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>In this study, the putative anion transporter 1 (ANTR1) from<sup> </sup><em>Arabidopsis thaliana</em> was shown to be localized to the chloroplast<sup> </sup>thylakoid membrane by Western blotting with two different peptide-specific<sup> </sup>antibodies. ANTR1 is homologous to the type I of mammalian Na<sup>+</sup>-dependent<sup> </sup>inorganic phosphate (P<sub>i</sub>) transporters. The function of ANTR1<sup> </sup>as a Na<sup>+</sup>-dependent P<sub>i</sub> transporter was demonstrated by heterologous<sup> </sup>expression and uptake of radioactive P<sub>i</sub> into <em>Escherichia coli</em><sup> </sup>cells. The expression of ANTR1 conferred increased growth rates<sup> </sup>to the transformed cells and stimulated P<sub>i</sub> uptake in a pH- and<sup> </sup>Na<sup>+</sup>-dependent manner as compared with the control cells. Among<sup> </sup>various tested effectors, P<sub>i</sub> was the preferred substrate. Although<sup> </sup>it competed with the uptake of P<sub>i</sub>, glutamate was not transported<sup> </sup>by ANTR1 into <em>E. coli</em>. In relation to its function as a P<sub>i</sub> transporter,<sup> </sup>several physiological roles for ANTR1 in the thylakoid membrane<sup> </sup>are proposed, such as export of P<sub>i</sub> produced during nucleotide<sup> </sup>metabolism in the thylakoid lumen back to the chloroplast stroma<sup> </sup>and balance of the trans-thylakoid H<sup>+</sup> electrochemical gradient<sup> </sup>storage.</p>
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