SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Rolstad Sindre 1976) "

Sökning: WFRF:(Rolstad Sindre 1976)

  • Resultat 11-20 av 45
  • Föregående 1[2]345Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Eckerström, Carl, et al. (författare)
  • Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia.
  • 2020
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 73:2, s. 597-607
  • Tidskriftsartikel (refereegranskat)abstract
    • Research has shown that mixed dementia is more common than previously believed but little is known of its early stages.To examine if incipient mixed dementia can be differentiated from incipient Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SVD) using neuropsychological tests, cerebrospinal fluid (CSF) markers, and magnetic resonance imaging markers.We included 493 patients and controls from the Gothenburg MCI study and used the dementia groups for marker selection (CSF total-tau (T-tau), phospho-tau (P-tau), and amyloid-β42 (Aβ42), 11 neuropsychological tests, and 92 regional brain volumes) and to obtain cut-off values which were then applied to the MCI groups.Incipient mixed dementia was best differentiated from incipient AD by the Word fluency F-A-S test and the Trail making test A. CSF T-tau, P-tau, and Aβ42 differentiated incipient mixed dementia from incipient SVD.Incipient mixed dementia is characterized by an AD-like biomarker profile and an SVD-like cognitive profile. Incipient mixed dementia can be separated from incipient AD and incipient SVD using CSF markers and cognitive testing.
  •  
12.
  • Eckerström, Carl, et al. (författare)
  • Combination of Hippocampal Volume and Cerebrospinal Fluid Biomarkers Improves Predictive Value in Mild Cognitive Impairment.
  • 2010
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - 1421-9824. ; 29:4, s. 294-300
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Mild cognitive impairment (MCI) is a heterogeneous condition, and the prognosis differs within the group. Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder. Objective: To examine the combined predictive value of hippocampal volume and CSF levels of total tau (T-tau) and beta-amyloid(42) (Abeta(42)) in stable and converting MCI patients. The participants (n = 68) included patients with MCI at baseline and who converted to dementia by the time of the 2-year follow-up (n = 21), stable MCI patients (n = 21) and healthy controls (n = 26). Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually, based on data from the 0.5-tesla MRI investigations at baseline. Baseline CSF levels of T-tau and Abeta(42) were measured using commercially available, enzyme-linked immunosorbent assays. Results: The converting MCI group had significantly smaller left hippocampi, lower CSF Abeta(42) and higher T-tau compared to both the stable MCI group and the healthy controls. Multivariate analysis revealed that a combination of the variables outperformed the prognostic ability of the separate variables. Conclusions: Hippocampal volumes supplement the prognostic accuracy of CSF Abeta(42) and T-tau in MCI.
  •  
13.
  • Eckerström, Carl, et al. (författare)
  • High white matter lesion load is associated with hippocampal atrophy in mild cognitive impairment.
  • 2011
  • Ingår i: Dementia and geriatric cognitive disorders. - 1421-9824. ; 31:2, s. 132-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Mild cognitive impairment (MCI) is a heterogeneous condition suggested as a prodromal state of Alzheimer's disease (AD) and subcortical vascular dementia (SVD). Recent findings suggest that white matter lesions (WML) may be associated with hippocampal atrophy. The objective of the study was to examine hippocampal and WML volumes in MCI patients and to examine if WML were linked to hippocampal atrophy.
  •  
14.
  • Eckerström, Carl, et al. (författare)
  • Similar pattern of atrophy in early- and late-onset Alzheimer's disease
  • 2018
  • Ingår i: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - 2352-8729. ; 10, s. 253-259
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Previous research on structural changes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) have reported inconsistent findings. Methods: In the present substudy of the Gothenburg MCI study, 1.5 T scans were used to estimate lobar and hippocampal volumes using FreeSurfer. Study participants (N = 145) included 63 patients with AD, (24 patients with EOAD [aged ≤65 years], 39 patients with LOAD [aged >65 years]), 25 healthy controls aged ≤65 years, and 57 healthy controls aged >65 years. Results: Hippocampal atrophy is the most prominent feature of both EOAD and LOAD compared with controls. Direct comparison between EOAD and LOAD showed that the differences between the groups did not remain after correcting for age. Discussion: Structurally, EOAD and LOAD does not seem to be different nosological entities. The difference in brain volumes between the groups compared with controls is likely due to age-related atrophy. © 2018 The Authors
  •  
15.
  • Eckerström, Carl, et al. (författare)
  • Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia. The Göteborg MCI study.
  • 2008
  • Ingår i: Journal of the Neurological Sciences. - 0022-510X. ; 272:1-2, s. 48-59
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss. Objective: To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampal volume to different forms of dementia, and to investigate the role of hippocampal side differences and rate of volume loss over time. Patients: The subjects (N = 68) include patients with MCI at baseline and progression to dementia at the two-year follow-up (N = 21), stable MCI patients (N = 21), and controls (N = 26). Among the progressing patients, 13 were diagnosed as having AD. Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually on the MRI investigations at baseline and at the two-year follow-up. Results: Hippocampal volumetry could predict conversion to dementia in both the AD and the non-AD subgroup of converters. Left hippocampal volume in particular discriminated between converting and stable MCI. Cut off points for individual discrimination were shown to be potentially useful. The converting MCI group had a significantly higher rate of hippocampal volume loss as compared to the stable MCI group. Conclusions: In MCI patients, hippocampal volumetry at baseline gives prognostic information about possible development of AD and non-AD dementia. Contrary to earlier studies, we found that left hippocampal volume has the best predictive power. Reliable predictions appear to be possible in many individual cases.
  •  
16.
  • Eckerström, Carl, et al. (författare)
  • The Göteborg MCI study – absolute and normalized hippocampal volumes in the prediction of dementia
  • 2007
  • Ingår i: The Annual General Meeting of the Swedish Society of Medicine, Nov. 28-30, 2007.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • Mild cognitive impairment (MCI) is a state where the cognitive functions are more impaired than what would be expected from aging alone but not enough to be described as dementia. In our material, there was an overrepresentation of men in the stable MCI group and an overrepre-sentation of women in the two other groups. Normalization of the data removed the gender-related differences in hippocampal volume and allowed for better utilization of the data. Hippocampal volumetry predicts conversion to dementia in MCI patients.
  •  
17.
  • Eckerström, Marie, 1981, et al. (författare)
  • High Prevalence of Stress and Low Prevalence of Alzheimer Disease CSF Biomarkers in a Clinical Sample with Subjective Cognitive Impairment
  • 2016
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - 1420-8008 .- 1421-9824. ; 42:1-2, s. 93-105
  • Tidskriftsartikel (refereegranskat)abstract
    • Background/Aims: Subjective cognitive impairment (SCI) is a trigger for seeking health care in a possible preclinical phase of Alzheimer's disease (AD), although the characteristics of SCI need clarification. We investigated the prevalence of psychosocial stress, depressive symptoms and CSF AD biomarkers in SCI and MCI (mild cognitive impairment). Methods: Memory clinic patients (SCI: n = 90; age: 59.8 ± 7.6 years; MCI: n = 160; age: 63.7 ± 7.0 years) included in the Gothenburg MCI study were examined at baseline. Variables were analyzed using logistic regression with SCI as dependent variable. Results: Stress was more prevalent in SCI (51.1%) than MCI (23.1%); p < 0.0005. SCI patients had more previous depressive symptoms (p = 0.006), but showed no difference compared to MCI patients considering current depressive symptoms. A positive CSF AD profile was present in 14.4% of SCI patients and 35.0% of MCI patients (p = 0.001). Stress (p = 0.002), previous stress/depressive symptoms (p = 0.006) and a negative CSF AD profile (p = 0.036) predicted allocation to the SCI group. Conclusion: Psychosocial stress is more prevalent in SCI than previously acknowledged. The high prevalence and long-term occurrence of stress/depressive symptoms in SCI in combination with a low prevalence of altered CSF AD biomarkers strengthens the notion that AD is not the most likely etiology of SCI.
  •  
18.
  • Eckerström, Marie, 1981, et al. (författare)
  • Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample.
  • 2017
  • Ingår i: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279. ; 16:8, s. 96-107
  • Tidskriftsartikel (refereegranskat)abstract
    • Subjective cognitive decline (SCD) and biomarker-based "at-risk" concepts such as "preclinical" Alzheimer's disease (AD) have been developed to predict AD dementia before objective cognitive impairment is detectable. We longitudinally evaluated cognitive outcome when using these classifications.Memory clinic patients (n = 235) were classified as SCD (n = 122): subtle cognitive decline (n = 36) and mild cognitive impairment (n = 77) and subsequently subclassified into SCDplus and National Institute on Aging-Alzheimer's Association (NIA-AA) stages 0 to 3. Mean (standard deviation) follow-up time was 48 (35) months. Proportion declining cognitively and prognostic accuracy for cognitive decline was calculated for all classifications.Among SCDplus patients, 43% to 48% declined cognitively. Among NIA-AA stage 1 to 3 patients, 50% to 100% declined cognitively. The highest positive likelihood ratios (+LRs) for subsequent cognitive decline (+LR 6.3), dementia (+LR 3.4), and AD dementia (+LR 6.5) were found for NIA-AA stage 2.In a memory clinic setting, NIA-AA stage 2 seems to be the most successful classification in predicting objective cognitive decline, dementia, and AD dementia.
  •  
19.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 45
  • Föregående 1[2]345Nästa
Typ av publikation
tidskriftsartikel (42)
konferensbidrag (1)
doktorsavhandling (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (43)
övrigt vetenskapligt (2)
Författare/redaktör
Rolstad, Sindre, 197 ... (45)
Wallin, Anders, 1950 (37)
Zetterberg, Henrik, ... (17)
Blennow, Kaj, 1958 (16)
Rolstad, S (7)
Landén, Mikael, 1966 (6)
visa fler...
Landen, M (6)
Hansen, Stefan, 1953 (6)
Johansson, Boo (6)
Ekman, CJ (5)
Svensson, Johan, 196 ... (5)
Abé, C (4)
Sellgren, C (4)
Malmgren, Helge, 194 ... (4)
Ekman, Carl-Johan (3)
Kettunen, Petronella (3)
Andreasson, Ulf, 196 ... (3)
Zetterberg, H (2)
Blennow, K (2)
Ekman, C-J (2)
Sellgren, Carl (2)
Olsson, E (2)
Jakobsson, J. (2)
Eriksson, Elias, 195 ... (1)
Eriksson, E (1)
Minthon, Lennart (1)
Börjesson-Hanson, An ... (1)
Wallin, A (1)
Petrovic, P (1)
Sparding, Timea (1)
Ingvar, M (1)
Sparding, T (1)
Johansson, B (1)
Borga, Magnus (1)
Gustavsson, Mikael K (1)
Karlsson, Mats (1)
Steineck, G (1)
Steineck, Gunnar, 19 ... (1)
Hellström, Per (1)
Portelius, Erik, 197 ... (1)
Kern, Silke (1)
Stridsberg, Mats (1)
Hansson, Oskar (1)
Ejnell, Hasse, 1948 (1)
Starck, Göran (1)
Joas, Erik, 1983 (1)
Komorowski, Jan (1)
Ekholm, Sven (1)
Ben-Menachem, Elinor ... (1)
Minthon, Lennart, 19 ... (1)
visa färre...
Lärosäte
Göteborgs universitet (45)
Karolinska Institutet (7)
Lunds universitet (1)
Uppsala universitet (1)
Linnéuniversitetet (1)
Språk
Engelska (45)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (39)
Naturvetenskap (1)
Humaniora (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy