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Sökning: WFRF:(Rolstad Sindre 1976)

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  • Föregående 123[4]5Nästa
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31.
  • Nordlund, Arto, 1962, et al. (författare)
  • Two year outcome of MCI subtypes and aetiologies in the Goteborg MCI study.
  • 2010
  • Ingår i: Journal of neurology, neurosurgery, and psychiatry. - 1468-330X. ; 81:5, s. 541-6
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective was to study the two year outcome of subjects diagnosed with Mild Cognitive Impairment (MCI). Two hundred and nine subjects diagnosed with MCI were examined with a comprehensive neuropsychological test battery and followed up after two years. After two years 34 subjects (16%) were lost for follow-up. Those subjects did not differ significantly in terms of MCI subclassification, MMSE score or age and education. Of the 175 subjects followed up, 8 (4.5%) had improved to normal, two with amnestic MCI, one from multiple domains MCI, three with single domain MCI and two without any significant impairment at baseline. Forty-four subjects (25%) had progressed to dementia. Out of these 35 were from the multidomain amnestic group and 9 from the multidomain non-amnestic group. The combination of Alzheimer-typical biomarkers (total-tau and amyloid beta) and multidomain amnestic MCI was the strongest predictor of progression to Alzheimer's disease, while vascular disease and multidomain amnestic MCI preceded mixed and vascular dementia. The results suggest that memory impairment alone, or impairment in any one cognitive domain alone, are rather benign conditions. Impairment in several cognitive domains is associated with a more severe outcome over two years. Also, 20% of the subjects who progressed to dementia, including Alzheimer's disease, did not show memory impairment at baseline, which suggests that memory impairment is not always the first symptom of even the most common dementia disorders.
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32.
  • Rolstad, Sindre, 1976, et al. (författare)
  • All cognitive systems but speed and visuospatial functions reduce the effect of CSF pathology on other systems.
  • 2012
  • Ingår i: Current Alzheimer research. - 1567-2050 .- 1875-5828. ; 9:9, s. 1043-1049
  • Tidskriftsartikel (refereegranskat)abstract
    • The concept of reserve can be conceived as differences in the ability to compensate for pathology by recruiting additional or alternative networks. The purpose of this study was to examine whether certain cognitive systems may compensate for the effect of CSF amyloid beta 42 (Aβ42) and total tau (T-tau) on other cognitive systems. Five hundred and nine participants underwent neuropsychological examination and lumbar puncture. Multiple regression was performed with interaction terms to test whether a cognitive system reduced the impact of CSF pathology on other systems. All cognitive systems except speed and visuospatial functions were associated with reduced effects of T-tau and Aβ42 on semantic memory, working memory and visuospatial abilities. The burden of Aβ42 was reduced more often than that of T-tau. Our results suggest that most cognitive systems may be beneficial to maintenance of cognitive performance despite CSF burden. The results support the notion of cognitive reserve.
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33.
  • Rolstad, Sindre, 1976, et al. (författare)
  • Amyloid-β₄₂ is associated with cognitive impairment in healthy elderly and subjective cognitive impairment.
  • 2011
  • Ingår i: Journal of Alzheimers Disorder. - 1387-2877. ; 26:1, s. 135-142
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to predict cognitive performance on the basis of the cerebrospinal fluid (CSF) biomarkers total tau (T-tau) and amyloid-β42 (Aβ42) in controls and patients at various impairment levels. Previous studies have found an association of CSF T-tau levels with cognitive symptoms, but it has been difficult to relate Aβ to cognition, and it has thus been hypothesized that Aβ reaches a plateau level prior to cognitive symptoms. A comprehensive battery of neuropsychological tests was subjected to factor analysis to yield aggregated cognitive domains. Linear regression models were performed for the total sample of the Gothenburg MCI study (n = 435) and for each level of impairment. Aβ42 and T-tau accounted for a significant proportion of performance in all cognitive domains in the total sample. In controls (n = 60) and patients with subjective cognitive impairment (n = 105), Aβ42 predicted a significant proportion of semantic and working memory performance. For patients with mild cognitive impairment (n = 170), T-tau had the most pronounced impact across cognitive domains, and more specifically on episodic memory, visuospatial, and speed/executive performance. For patients with dementia (n = 100), the most pronounced impacts of Aβ42 were found in episodic memory and visuospatial functioning, while T-tau was substantially associated with episodic memory. Our results suggest that cognition is related to CSF biomarkers regardless of impairment level. Aβ42 is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase.
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34.
  • Rolstad, Sindre, 1976, et al. (författare)
  • Biomarkers in relation to cognitive reserve in patients with mild cognitive impairment--proof of concept.
  • 2009
  • Ingår i: Dementia and geriatric cognitive disorders. - 1421-9824. ; 27:2, s. 194-200
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The concept of the cognitive reserve (CR) posits that factors such as education enable compensation for the effect of brain pathology. Consequently, pathology should be more pronounced in individuals with higher CR before becoming clinically apparent. Biomarkers such as total tau (t-tau) and beta-amyloid 42 (Abeta42) may be surrogates for pathology in relation to CR in patients with neurodegenerative disease. OBJECTIVE: To examine the applicability of biomarkers as surrogates for pathology in relation to the CR in patients with mild cognitive impairment (MCI) either converting to dementia or remaining stable at follow-up. METHOD: Comparisons of baseline t-tau, Abeta42, educational years and global cognition for MCI patients either converting to dementia (n = 57) or remaining stable (n = 91) were made. Patients converting to dementia were grouped on the basis of educational level and compared considering biomarkers and neuropsychological tests. RESULTS: Stable MCI patients were better educated, performed better cognitively, had higher Abeta42 levels and lower levels of t-tau. Converting MCI patients with higher education had lower levels of Abeta42 and performed equally in neuropsychological tests compared to those with lower education. CONCLUSION: Our results suggest that highly educated MCI patients subsequently converting to dementia display more amyloid pathology.
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35.
  • Rolstad, Sindre, 1976, et al. (författare)
  • Cerebrospinal fluid biomarkers mirror rate of cognitive decline.
  • 2013
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 34:4, s. 949-56
  • Tidskriftsartikel (refereegranskat)abstract
    • The ability to predict future decline in cognitive systems using the cerebrospinal fluid (CSF) biomarkers 42 amino acid form of amyloid-β (Aβ42) and total tau (T-tau) is not fully understood. In a clinical sample ranging from cognitively healthy to dementia (n = 326), linear regression models were performed in order to investigate the ability of CSF biomarkers to predict cognitive decline in all cognitive domains from baseline to 2-year follow-up. Gender, age, and years of education were included as covariates. In patients with subjective cognitive impairment, T-tau had a small impact on executive functions (r2 = 0.07). T-tau had a small to moderate influence (r2 = 0.06-0.11) on all cognitive functions with the exception of visuospatial functions in patients with mild cognitive impairment (MCI). In patients with dementia, the impact of T-tau was large (r2 = 0.29) on semantic memory. Aβ42 had a small effect (r2 = 0.07) on speed and executive functions in MCI. In patients with dementia, Aβ42 had a moderate influence (r2 = 0.13-0.24) on semantic and verbal working memory/fluency. Our results speak in favor of the notion that CSF biomarkers reflect the rate of cognitive decline across the continuum of cognitive impairment from healthy to dementia. CSF predicted subsequent decline in more cognitive domains among MCI cases, but the impact was most pronounced in patients with dementia.
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36.
  • Rolstad, Sindre, 1976, et al. (författare)
  • Cognitive reserve in relation to abeta42 in patients converting from MCI to dementia - a follow-up report.
  • 2009
  • Ingår i: Dementia and geriatric cognitive disorders. - 1421-9824. ; 28:2, s. 110-5
  • Tidskriftsartikel (refereegranskat)abstract
    • The concept of the cognitive reserve (CR) hypothesizes that premorbid factors such as education enable compensation for the manifestation of brain pathology. Accordingly, pathology should be more prominent in individuals with higher CR before becoming clinically apparent. Previously, we found that patients subsequently converting to dementia with higher CR had lower concentrations of amyloid beta 42 (abeta42) as compared to patients with lower CR. However, the interaction between time, biomarkers, neuropsychological performance and CR is yet to be established. OBJECTIVE: To study the relation between biomarkers, neuropsychological performance and CR longitudinally. METHOD: A mixed between-within subject analysis of variance was performed for longitudinal analysis. Paired t tests were used for within group comparisons. RESULTS: Patients with higher CR (n = 15) had significantly lower concentrations of abeta42 at both time points compared to those with medium (n = 23) and lower CR (n = 28). Also, abeta42 concentrations decreased significantly from baseline to follow-up in patients with higher and medium CR. Groups performed comparably on neuropsychological tests. CONCLUSION: This study provides further support for the applicability of abeta42 as a substitute for pathology in relation to CR. Also, abeta42 reflects the disease progression in patients with higher and medium CR.
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37.
  • Rolstad, Sindre, 1976, et al. (författare)
  • Differential Impact of Neurofilament Light Subunit on Cognition and Functional Outcome in Memory Clinic Patients with and without Vascular Burden
  • 2015
  • Ingår i: Journal of Alzheimers Disease. - 1387-2877. ; 45:3, s. 873-881
  • Tidskriftsartikel (refereegranskat)abstract
    • The neurofilament light (NF-L) subunit is mainly expressed in large-caliber myelinated axons, and elevated concentrations in the cerebrospinal fluid (CSF) are correlated with damage to white matter and subcortical regions. Because the correlation between NF-L and cognition and functional impairment is largely unknown, we investigated associations in patients (n = 622) with (n = 199) and without (n = 423) vascular burden in subjective cognitive impairment (SCI, n = 168), mild cognitive impairment (MCI, n = 261), and dementia (n = 193). Patients were staged according to disease severity and the presence/absence of cerebrovascular disease. CSF amyloid-beta(1-42) (A beta(1-42))was included in all models due to its concomitant influence on vascular and primary etiology. Linear regression was used to assess associations between NF-L and A beta(1-42) and five cognitive domains of a comprehensive neuropsychological battery as well as with functional impairment using the Clinical Dementia Rating. Changes in these outcomes at the 2-year follow-up were also evaluated. In SCI and MCI patients with vascular burden, higher NF-L concentrations were associated with baseline cognitive performance (beta = -0.38 to -0.58) and executive decline (beta = -0.44). Lower A beta(1-42) levels were associated with worse cognitive performance in dementia (beta = 0.46 to 0.51). In MCI and dementia patients without vascular burden, higher NF-L (beta = -0.30 to -0.34) and lower A beta(1-42) concentrations (beta = 0.30) were associated with reduced cognitive performance. Higher NF-L concentrations (beta = -0.26) were associated with functional decline in patients with vascular burden. CSF NF-L is associated with cognition in patients with and without vascular etiology. These associations were greater in pre-dementia phases in those with vascular etiology and vice versa in those without vascular burden.
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38.
  • Rolstad, Sindre, 1976, et al. (författare)
  • High Education May Offer Protection Against Tauopathy in Patients with Mild Cognitive Impairment.
  • 2010
  • Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 21:1, s. 221-8
  • Tidskriftsartikel (refereegranskat)abstract
    • The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau and amyloid-beta{42}, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.
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39.
  • Rolstad, Sindre, 1976 (författare)
  • The reserve concept in patients with Mild Cognitive Impairment – new approaches
  • 2010
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • The concept of reserve stems from the observation that premorbid factors, e.g. education, result in variation in the response to any kind of brain pathology. As subjects with higher reserve tolerate more neuropathology, symptomatic expression of pathology is delayed. It is thus predicted that neuropathology should be more pronounced in those with higher reserve as compared to those with lower at the same level of clinical severity. Most research within the reserve paradigm has been conducted on patients with established diagnoses, mainly Alzheimer’s disease, but knowledge on the modifying effects of reserve in preclinical, Mild Cognitive Impairment (MCI), and early phases of dementia is limited. The main purpose was to investigate if use of cerebrospinal fluid (CSF) biomarkers, would enable studies of reserve in earlier phases. Specifically, the 42 amino acid form of beta-amyloid (abeta42), mirroring amyloid plaques depositions, and CSF total tau (t-tau), reflecting axonal degeneration, were used as surrogate measures for neuropathology. Another purpose was to explore if patients with higher reserve diverge from patients with intermediate and lower reserve in terms of CSF pathology, and cognitive functioning in various disease phases. As premorbid intelligence Quotient (IQ), cognitive functioning prior to manifest disease, may be a better proxy for reserve than education, the final objective was to construct a test for assessment of premorbid IQ in Swedish. In summary, we found that patients with higher reserve were distinguishable from those with intermediate and lower reserve with regards to abeta42 pathology, but not clinical manifestations. The incongruence between pathology and clinical outcome indicates compensation for neuropathology. We also found that abeta42 may be sensitive to disease progress when taking level of reserve into account. Patients with higher reserve with stable MCI had lower concentrations of CSF t-tau, but comparable abeta42 concentrations. This finding may either indicate a true protective effect for education, or suggests that higher education promotes cognitive stimulation resulting in better axonal integrity. Also, a test for assessment of premorbid IQ, NART-SWE, was successfully constructed and found to have satisfactory psychometric properties. The results of these studies may contribute to earlier identification, and consequentially treatment of patients with higher reserve at risk for dementia.
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40.
  • Rolstad, Sindre, 1976, et al. (författare)
  • The Swedish National Adult Reading Test (NART-SWE): a test of premorbid IQ.
  • 2008
  • Ingår i: Scandinavian journal of psychology. - 0036-5564. ; 49:6, s. 577-82
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this study was to construct a Swedish version of the National Adult Reading Test (NART-SWE), a test for assessment of premorbid IQ, and to investigate its validity and reliability on healthy controls and patients with mild Alzheimer's disease. As Swedish pronunciation rules are fixed, NART-SWE was constructed using loan words. NART-SWE has satisfactory psychometric properties: Inter-rater and retest reliability as well as internal consistency are very high. The NART-SWE demonstrates face validity. In addition, high correlation with IQ was obtained. A significant model emerged when using NART-SWE to predict IQ. Furthermore, no significant differences were observed when comparing performance for healthy controls' with that of patients with Alzheimer's disease on NART-SWE. It does appear that reading of irregular words is intact in mild Alzheimer's disease.
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