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Sökning: WFRF:(Ross Owen A)

  • Resultat 41-43 av 43
  • Föregående 1234[5]
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41.
  • Puschmann, Andreas, et al. (författare)
  • CHCHD2 and Parkinson's disease
  • 2015
  • Ingår i: Lancet Neurology. - : Lancet Ltd. - 1474-4465. ; 14:7, s. 679-679
  • Tidskriftsartikel (refereegranskat)
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42.
  • Puschmann, Andreas, et al. (författare)
  • Human leukocyte antigen variation and Parkinson's disease.
  • 2011
  • Ingår i: Parkinsonism & Related Disorders. - : Elsevier. - 1873-5126. ; 17, s. 376-378
  • Tidskriftsartikel (refereegranskat)abstract
    • A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ancestry. In that study, the minor rs3129882 allele (G) was associated with an increased risk of PD under an additive model. Due to the increased likelihood of obtaining false positive results in GWA studies compared to studies conducted based on a hypothesis-driven approach, repeated validation of findings from GWA studies are necessary. Herein, we evaluated the association between rs3129882 and PD in three different Caucasian patient-control series (combined 1313 patients and 1305 controls) from the US, Ireland, and Poland. We observed no association (OR: 0.96, P = 0.50) between rs3129882 and PD when analyzing our data under an additive or dominant model. In contrast, when examined under a recessive model, the GG genotype was observed to be protective in the Irish (OR: 0.55, P = 0.008), Polish (OR: 0.67, P = 0.040) and combined (OR: 0.75, P = 0.006) patient-control series. In view of these diverging results, the exact role of genetic variation at the HLA region and susceptibility to PD remains to be resolved.
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43.
  • Sproviero, William, et al. (författare)
  • ATXN2 trinucleotide repeat length correlates with risk of ALS
  • 2017
  • Ingår i: Neurobiology of Aging. - 0197-4580 .- 1558-1497. ; 51, s. 178.e1-178.e9
  • Tidskriftsartikel (refereegranskat)abstract
    • We investigated a CAG trinucleotide repeat expansion in the ATXN2 gene in amyotrophic lateral sclerosis (ALS). Two new case-control studies, a British dataset of 1474 ALS cases and 567 controls, and a Dutch dataset of 1328 ALS cases and 691 controls were analyzed. In addition, to increase power, we systematically searched PubMed for case-control studies published after 1 August 2010 that investigated the association between ATXN2 intermediate repeats and ALS. We conducted a meta-analysis of the new and existing studies for the relative risks of ATXN2 intermediate repeat alleles of between 24 and 34 CAG trinucleotide repeats and ALS. There was an overall increased risk of ALS for those carrying intermediate sized trinucleotide repeat alleles (odds ratio 3.06 [95% confidence interval 2.37-3.94]; p = 6 × 10(-18)), with an exponential relationship between repeat length and ALS risk for alleles of 29-32 repeats (R(2) = 0.91, p = 0.0002). No relationship was seen for repeat length and age of onset or survival. In contrast to trinucleotide repeat diseases, intermediate ATXN2 trinucleotide repeat expansion in ALS does not predict age of onset but does predict disease risk.
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  • Resultat 41-43 av 43
  • Föregående 1234[5]
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