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21.
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22.
  • Anders, Emma, et al. (författare)
  • Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1 : a novel mechanism for regulation of MCP-1 production and function
  • 2018
  • Ingår i: Biochemical Journal. - Portland Press Limited. - 0264-6021. ; 475:4, s. 775-786
  • Tidskriftsartikel (refereegranskat)abstract
    • The protein gC1qR (globular C1q receptor), also named p33, was originally identified as a binding partner of the globular heads of C1q in the complement system. gC1qR/p33 is abundantly expressed in many cell types, but the functional importance of this protein is not completely understood. Here, we investigate the impact of gC1qR/p33 on the production and function of the pathophysiologically important chemokine monocyte chemoattractant protein-1 (MCP-1) and the underlying molecular mechanisms. Knockdown of gC1qR/p33 negatively regulated the production of MCP-1, but had no effect on the expression of transcript for MCP-1 in human periodontal ligament cells, suggesting a translational/post-translational mechanism of action. Laser scanning confocal microscopy showed considerable cytosolic co-localization of gC1qR/p33 and MCP-1, and co-immunoprecipitation disclosed direct physical interaction between gC1qR/p33 and MCP-1. Surface plasmon resonance analysis revealed a high-affinity binding (KD = 10.9 nM) between gC1qR/p33 and MCP-1. Using a transwell migration assay, we found that recombinant gC1qR/p33 enhances MCP-1-induced migration of human THP-1 monocytes, pointing to a functional importance of the interaction between gC1qR/p33 and MCP-1. An in vitro assay revealed a rapid turnover of the MCP-1 protein and that gC1qR/ p33 stabilizes MCP-1, hence preventing its degradation. We propose that endogenous gC1qR/p33 physically interacts with MCP-1 causing stabilization of the MCP-1 protein and stimulation of its activity in human periodontal ligament cells, suggesting a novel gC1qR/p33-mediated pro-inflammatory mechanism of action.
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23.
  • Anders, Emma, et al. (författare)
  • LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis
  • 2018
  • Ingår i: Biochemical and Biophysical Research Communications. - Elsevier. - 0006-291X. ; 501:1, s. 280-285
  • Tidskriftsartikel (refereegranskat)abstract
    • The host defense peptide LL-37 is cytotoxic for bacteria but it has also been reported to reduce host cell viability through an intracellular mechanism. LL-37-evoked cytotoxicity may be involved in the loss of bone tissue in periodontitis which is an inflammatory disease characterized by high concentrations of LL-37 observed locally in the periodontal tissue at the inflammation process. Here, we showed that LL-37 reduced human osteoblast-like MG63 cell viability assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and increased plasma membrane permeability determined by measuring intracellular Ca2+ levels and lactate dehydrogenase (LDH) release. Treatment with chlorpromazine, a well-recognized inhibitor of clathrin-mediated endocytosis, reduced cellular uptake of synthesized LL-37 b y about 30% assessed by Western blotting and ELISA, while filipin, an inhibitor of caveolin-mediated endocytosis, had no effect. The chlorpromazine-induced attenuation of LL-37 uptake was not associated with modulation of LL-37-induced cytotoxicity and LL-37-evoked plasma membrane permeability. Clathrin heavy chain 2 is a major protein of the polyhedral coat of coated pits and vesicles encoded by clathrin heavy chain like 1 gene. Down-regulation of clathrin heavy chain like 1 gene activity by siRNA reduced uptake of LL-37 but did not affect LL-37-induced cytotoxicity and permeability. Thus, we show, using both a pharmacological approach and knockdown of clathrin heavy chain like 1 expression, that LL-37-induced MG63 cell cytotoxicity and permeability occurs independently of LL-37 uptake via clathrin-mediated endocytosis.
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24.
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25.
  • Andersson, Peter, et al. (författare)
  • Active Matrix Displays Based on All-Organic Electrochemical Smart Pixels Printed on Paper
  • 2002
  • Ingår i: Advanced Materials. - Weinheim, Germany : Wiley-VCH Verlagsgesellschaft. - 0935-9648. ; 14:20, s. 1460-1464
  • Tidskriftsartikel (refereegranskat)abstract
    • An organic electronic paper display technology (see Figure and also inside front cover) is presented. The electrochromic display cell together with the addressing electrochemical transistor form simple smart pixels that are included in matrix displays, which are achieved on coated cellulose-based paper using printing techniques. The ion-electronic technology presented offers an opportunity to extend existing use of ordinary paper. 
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26.
  • Andersson, Peter, et al. (författare)
  • Organic Electrochemical Smart Pixels
  • 2003
  • Ingår i: Materials Research Society Symposium Proceedings. ; s. D6.6
  • Konferensbidrag (refereegranskat)
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27.
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28.
  • Aronson, Åke, et al. (författare)
  • Ulv i Skandinavia : Statusrapport for vinteren 2009-2010
  • 2010
  • Rapport (övrigt vetenskapligt)abstract
    • The wolves in Sweden and Norway are members of a joint Scandinavian wolf population. In a combined Swedish-Norwegian monitoring project, wolves on the Scandinavian Peninsula were located and counted during the winter of 2009-2010. In Sweden, County administrative boards perform the fieldwork and collection of field data (snow-tracking, DNA-samples), whereas the Wildlife Damage Center (VSC) at Grimsö Research Station was responsible for evaluating and summarizing the results of the wolf monitoring. In Norway, wolf biologists at Hedmark University College and a genetist at Rovdata (Trondheim) in cooperation with the Norwegian Nature Inspectorate (SNO) were responsible for the monitoring of resident and non-resident wolves, respectively. Furthermore, cooperative wolf pack monitoring has been carried out in Fennoscandia in collaboration with Finland. A large number of volunteers and organizations such as hunting associations in both countries and the Swedish Carnivore Association also report observations and participate in wolf monitoring activities. The estimated number of wolves in Scandinavia is mainly based on long distances of ground tracking on snow, but also by radio-telemetry and DNA-analysis. The estimate was restricted to the period of October 1, 2009 – February 28, 2010. To guarantee the quality of the reports used, the majority have been checked in the field by the project, or by other personnel with experience of ground tracking wolves on snow. Wolves were classified as 1) family groups (packs), 2) scent-marking pairs, 3) other resident wolves, or 4) other wolves. The results were presented as minimum-maximum numbers where the minimum was exclusively based on confirmed field-checked reports, while the maximum also included other reports. A total of 252-291 wolves were estimated on the Scandinavian Peninsula during the 2009-2010 winter. Among these, 28 packs included 165-175 wolves, and 44-49 wolves belonged to 21-24 scent-marking pairs. The majority of the wolves (186-215) were located in Sweden. Of the 33-39 wolves restricted to Norway, 21-23 were members of 3 packs, 6 were scent-marking pair members, none were classified as “other resident wolves”, and 6-10 were classified as “other wolves”. Areas were utilized on both sides of the national border between Sweden and Norway by 33-37 resident wolves. Successful reproduction in the spring of 2009 was confirmed in 26 of the Scandinavian wolf territories. Among these, 19 litters were born in Sweden, 4 litters was born in a transboundary packs, and 3 litters grew up in Norway. In 2009, two Finnish-Russian male wolves reproduced for the second time, one litter in Sweden (the Galven territory) and one in Norway (the Kynna territory). In Finland, during the winter 2009-10, a total of 76-78 wolves in 15 packs were estimated to have exclusively Finnish territories. In addition 72-74 wolves were pack members within 13 territories across the Finnish-Russian border
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29.
  • Aronson, Åke, et al. (författare)
  • Ulv i Skandinavia : statusrapport for vinteren 2010-2011
  • 2011
  • Rapport (övrigt vetenskapligt)abstract
    • The wolves in Sweden and Norway are members of a joint Scandinavian wolf population. In a combined Swedish-Norwegian monitoring project, wolves on the Scandinavian Peninsula were located and counted during the winter of 2010-2011. In Sweden, County administrative boards perform the fieldwork and collection of field data (snow-tracking, DNA-samples), whereas the Wildlife Damage Center (VSC) at Grimsö Research Station was responsible for evaluating and summarizing the results of the wolf monitoring. In Norway, wolf biologists at Hedmark University College and a genetist at Rovdata (Trondheim) in cooperation with the Norwegian Nature Inspectorate (SNO) were responsible for the monitoring of resident and non-resident wolves, respectively. Furthermore, cooperative wolf pack monitoring has been carried out in Fennoscandia in collaboration with Finland. A large number of volunteers and organizations such as hunting associations in both countries and the Swedish Carnivore Association also report observations and participate in wolf monitoring activities. The estimated number of wolves in Scandinavia is mainly based on long distances of ground tracking on snow, but also by DNA-analysis and radio-telemetry. The estimate was restricted to the period of October 1, 2010 – February 28, 2011. To guarantee the quality of the reports used, the majority have been checked in the field by the project, or by other personnel with experience of ground tracking wolves on snow. Wolves were classified as 1) family groups (packs), 2) scent-marking pairs, 3) other resident wolves, or 4) other wolves. The results were presented as minimum-maximum numbers where the minimum was exclusively based on confirmed field-checked reports, while the maximum also included other reports. A total of 289-325 wolves were estimated on the Scandinavian Peninsula during the 2010-2011 winter. Among these, 31 packs included 183-189 wolves, and 57-61 wolves belonged to 27-30 scent-marking pairs. The majority of the wolves (235-266) were located in Sweden, of which 149-154 were members of 25 packs, 43-44 lived in 20-22 scent-marking pairs, 4 were classified as “other resident wolves”, and 39-64 were classified as “other wolves”. Of the 32-34 wolves restricted to Norway, 18-19 were members of 3 packs, 8 were scent-marking pair members, one was classified as “other resident wolves”, and 5-6 were classified as “other wolves”. Another 22-25 resident wolves lived in 6-7 packs or scent-marking pairs in territories covering areas on both sides of the Swedish-Norwegian border. Successful reproduction in spring 2010 was confirmed in 31 of the Scandinavian wolf territories. Among these, 25 litters were born in Sweden, 3 litters were born in transboundary packs, and 3 litters grew up in Norway. In 2010, two Finnish-Russian male wolves reproduced for the third time, one litter in Sweden (the Galven territory) and one in Norway (the Kynna territory). In Finland, during the winter 2010-11, a total of 48 wolves in 8 packs were estimated to have exclusively Finnish territories. In addition 59-64 wolves were pack members within 11 territories across the Finnish-Russian border
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30.
  • Axelsson, Robert, et al. (författare)
  • Evaluation of Multi-level Social Learning for Sustainable Landscapes : Perspective of a Development Initiative in Bergslagen, Sweden
  • 2013
  • Ingår i: Ambio. - Springer Netherlands. - 0044-7447. ; 42:2, s. 241-253
  • Tidskriftsartikel (refereegranskat)abstract
    • To implement policies about sustainable landscapes and rural development necessitates social learning about states and trends of sustainability indicators, norms that define sustainability, and adaptive multi-level governance. We evaluate the extent to which social learning at multiple governance levels for sustainable landscapes occur in 18 local development initiatives in the network of Sustainable Bergslagen in Sweden. We mapped activities over time, and interviewed key actors in the network about social learning. While activities resulted in exchange of experiences and some local solutions, a major challenge was to secure systematic social learning and make new knowledge explicit at multiple levels. None of the development initiatives used a systematic approach to secure social learning, and sustainability assessments were not made systematically. We discuss how social learning can be improved, and how a learning network of development initiatives could be realized.
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