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Sökning: WFRF:(Vonk Judith M)

  • Resultat 21-23 av 23
  • Föregående 12[3]
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  • Gryparis, Alexandros, et al. (författare)
  • Acute effects of ozone on mortality from the "air pollution and health : a European approach" project.
  • 2004
  • Ingår i: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 170:10, s. 1080-7
  • Tidskriftsartikel (refereegranskat)abstract
    • In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at least 3 years since 1990. Effect estimates were obtained for each city with city-specific models and were combined using second-stage regression models. No significant effects were observed during the cold half of the year. For the warm season, an increase in the 1-hour ozone concentration by 10 mug/m3 was associated with a 0.33% (95% confidence interval [CI], 0.17-0.52) increase in the total daily number of deaths, 0.45% (95% CI, 0.22-0.69) in the number of cardiovascular deaths, and 1.13% (95% CI, 0.62-1.48) in the number of respiratory deaths. The corresponding figures for the 8-hour ozone were similar. The associations with total mortality were independent of SO2 and particulate matter with aerodynamic diameter less than 10 mum (PM10) but were somewhat confounded by NO2 and CO. Individual city estimates were heterogeneous for total (a higher standardized mortality rate was associated with larger effects) and cardiovascular mortality (larger effects were observed in southern cities). The dose-response curve of ozone effects on total mortality during the summer did not deviate significantly from linearity.
  • Mogensen, Ida, et al. (författare)
  • Blood eosinophil level and lung function trajectories – cross-sectional and longitudinal studies in European cohorts
  • Annan publikation (övrigt vetenskapligt)abstract
    • Background: Elevated blood eosinophils have been associated with lower lung function and are believed to be associated with an accelerated lung function decline.Method: Blood eosinophils were measured in four cohorts:  <45 years old cohort within the Vlagtwedde-Vlaardingen (V&V) study,  the Uppsala cohort of the European Community Respiratory Health Survey (ECRHS-Uppsala ; <45 years),  ≥45 years cohort within the V&V study and  the Rotterdam study (≥45 years). Blood eosinophils at baseline were classified as normal (<300 cells/μL) or elevated (≥300 cells/μL). Lung function was measured at baseline and follow-up with spirometry: forced exhaled volume during the first second (FEV1), vital capacity (VC) and their ratio FEV1/VC. The association between blood eosinophils and lung function was tested cross-sectionally using linear regression and longitudinally using a mixed model, both adjusted for age, sex, height, pack-years smoking and smoking status. Stratified analyses were done for asthma.Results: Elevated blood eosinophils associated to lower FEV1 (regression coefficient -149mL (95% Confidence Interval: -191; -107), VC (-124mL (-169; -78)) and FEV1/VC (-1.3% (-1.9; -0.7)) at baseline in the two <45 years cohorts, and to lower FEV1 (-79mL (-116; -41)) and FEV1/VC (-1.8% (-2.6; -1.0)) in the two ≥45 years cohorts. Longitudinally, elevated compared to normal blood eosinophils were associated with an excess decline in FEV1 (-5.7mL/year (-11.1; -0.4), V&V <45 years) and VC (-12mL/year (-23.6; -0.9), ECRHS-Uppsala) only in asthmatics.Conclusion: Elevated blood eosinophils are associated with lower lung function in the general population and with an accelerated lung function decline among asthmatics.
  • Weidner, Julie, et al. (författare)
  • Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease
  • Ingår i: Respiratory Research. - : BioMed Central (BMC). - 1465-9921. ; 18:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: It has been observed that mice lacking the sulfatase modifying factor (Sumf1) developed an emphysema-like phenotype. However, it is unknown if SUMF1 may play a role in Chronic Obstructive Pulmonary Disease (COPD) in humans. The aim was to investigate if the expression and genetic regulation of SUMF1 differs between smokers with and without COPD. Methods: SUMF1 mRNA was investigated in sputum cells and whole blood from controls and COPD patients (all current or former smokers). Expression quantitative trait loci (eQTL) analysis was used to investigate if single nucleotide polymorphisms (SNPs) in SUMF1 were significantly associated with SUMF1 expression. The association of SUMF1 SNPs with COPD was examined in a population based cohort, Lifelines. SUMF1 mRNA from sputum cells, lung tissue, and lung fibroblasts, as well as lung function parameters, were investigated in relation to genotype. Results: Certain splice variants of SUMF1 showed a relatively high expression in lung tissue compared to many other tissues. SUMF1 Splice variant 2 and 3 showed lower levels in sputum cells from COPD patients as compared to controls. Twelve SNPs were found significant by eQTL analysis and overlapped with the array used for genotyping of Lifelines. We found alterations in mRNA expression in sputum cells and lung fibroblasts associated with SNP rs11915920 (top hit in eQTL), which validated the results of the lung tissue eQTL analysis. Of the twelve SNPs, two SNPs, rs793391 and rs308739, were found to be associated with COPD in Lifelines. The SNP rs793391 was also confirmed to be associated with lung function changes. Conclusions: We show that SUMF1 expression is affected in COPD patients compared to controls, and that SNPs in SUMF1 are associated with an increased risk of COPD. Certain COPD-associated SNPs have effects on either SUMF1 gene expression or on lung function. Collectively, this study shows that SUMF1 is associated with an increased risk of developing COPD.
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  • Resultat 21-23 av 23
  • Föregående 12[3]
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