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Sökning: WFRF:(Wanders I.)

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  • Föregående 1[2]3Nästa
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  • Koratkar, A, et al. (författare)
  • The disappearing broad absorption lines and variable emission lines in NGC 3516
  • 1996
  • Ingår i: ASTROPHYSICAL JOURNAL. - : UNIV CHICAGO PRESS. - 0004-637X. ; 470:1, s. 378-393
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • The Seyfert 1 galaxy NGC 3516 was monitored during 1993 February 16-May 13 by IUE every 4 days for the first month, and then every 2 days for 2 months giving a total of 40 observations. This paper gives the initial results from this campaign, (1) The broa
  • Nystrom, N., et al. (författare)
  • Human enterovirus species B in ileocecal Crohn's disease
  • 2013
  • Ingår i: Clin Transl Gastroenterol. - 2155-384X (Electronic) ; 4, s. e38-
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Advanced ileocecal Crohn's disease (ICD) is characterized by strictures, inflammation in the enteric nervous system (myenteric plexitis), and a high frequency of NOD2 mutations. Recent findings implicate a role of NOD2 and another CD susceptibility gene, ATG16L1, in the host response against single-stranded RNA (ssRNA) viruses. However, the role of viruses in CD is unknown. We hypothesized that human enterovirus species B (HEV-B), which are ssRNA viruses with dual tropism both for the intestinal epithelium and the nervous system, could play a role in ICD. METHODS: We used immunohistochemistry and in situ hybridization to study the general presence of HEV-B and the presence of the two HEV-B subspecies, Coxsackie B virus (CBV) and Echovirus, in ileocecal resections from 9 children with advanced, stricturing ICD and 6 patients with volvulus, and in intestinal biopsies from 15 CD patients at the time of diagnosis. RESULTS: All patients with ICD had disease-associated polymorphisms in NOD2 or ATG16L1. Positive staining for HEV-B was detected both in the mucosa and in myenteric nerve ganglia in all ICD patients, but in none of the volvulus patients. Expression of the cellular receptor for CBV, CAR, was detected in nerve cell ganglia. CONCLUSIONS: The common presence of HEV-B in the mucosa and enteric nervous system of ICD patients in this small cohort is a novel finding that warrants further investigation to analyze whether HEV-B has a role in disease onset or progress. The presence of CAR in myenteric nerve cell ganglia provides a possible route of entry for CBV into the enteric nervous system.
  • Malmström, Per-Uno, et al. (författare)
  • AdCD40L Immunogene Therapy for Bladder Carcinoma : The First Phase I/IIa Trial
  • 2010
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 16:12, s. 3279-3287
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Immunotherapy with bacillus Calmette-Guérin (BCG) instillation is recommended for high-risk non-muscle invasive bladder cancer. BCG is not effective in advanced tumors, and better alternatives are warranted. Immunostimulating gene therapy with adenoviral vectors expressing CD40L (AdCD40L) has shown efficacy in tumor models. CD40L stimulates systemic immunity and may be effective in local and invasive human disease. EXPERIMENTAL DESIGN: Patients with invasive bladder cancer scheduled for cystectomy or patients with Ta tumors were enrolled in a Phase I/IIa trial. Patients were treated with three cycles of intra-bladder Clorpactin WCS-90 prewash followed by AdCD40L instillation one week apart. Safety, gene transfer, immune effects and anti-tumor responses were monitored. RESULTS: All eight recruited patients were treated as scheduled, and therapy was well tolerated. The main adverse effect was transient local pain during prewash. Postoperatively, urinary tract infections and one case of late septicemia with elevated potassium were reported. No adverse events were ascribed to vector therapy. Gene transfer was detected in biopsies and bladders were heavily infiltrated with T-cells. The effector marker IFNg increased in biopsies while levels of circulating T regulatory cells were reduced. Histological evaluation indicated that AdCD40L therapy reduced the load of malignant cells. CONCLUSION: To our knowledge, this is the first report on immunogene therapy in bladder cancer and the first utilizing AdCD40L in vivo. Local AdCD40L gene therapy was safe, boosted immune activation and should be further evaluated as single or adjuvant therapy for urothelial malignancies.
  • Perry, J. J., et al. (författare)
  • Hysteresis in broad-line regions of active galactic nuclei
  • 1994
  • Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 271:3, s. 561-572572
  • Tidskriftsartikel (refereegranskat)abstract
    • The response of emission-line luminosities to changes in the observed continuum in active galaxies is commonly used for reverberation mapping (RM) of the emission-line region. The method assumes regularity in the continuum source and linearity in the line response to the continuum, and that the phase-space distribution of the line-emitting gas is constant in time. The wealth of information contained in the detailed line profiles is under-utilized in current methods of RM. The authors propose a new method to improve this situation. The authors define normalized profiles and show how their use enables one to explore details of the emission-line region that have hitherto eluded detection. Furthermore, the authors investigate the possibility of testing the validity of the assumptions as used in the standard application of RM. The authors present new methods, the hysteresis test and the Q concept - also based on the line profiles - to test the basic assumptions of RM. The test fails when applied to NGC 4151. The authors show that there is good evidence either for significantly extended and complex emission-line regions, or for changes in the mass distribution over time-scales of months or more - i.e. on time-scales comparable to the length of typical observing campaigns
  • Ronnback, J., et al. (författare)
  • Host galaxies of intermediate redshift radio-loud and radio-quiet quasars
  • 1996
  • Ingår i: Monthly notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 283:1, s. 282-296296
  • Tidskriftsartikel (refereegranskat)abstract
    • In a search for host galaxies associated with quasars, the authors present results from deep CCD imaging using the European Southern Observatory 3.5-m New Technology Telescope. Altogether 21 targets, 12 radio-loud and nine radio-quiet quasars, were observed in R, and additional V and Gunn i images were collected for a subgroup of these. The quasar redshifts are between 0.4 and 0.8, a range largely unexplored in previous studies. At these redshifts the R band corresponds to a rest-frame wavelength between 4600 and 3600 Aring. Thus, the authors are primarily probing the light from young stellar components of the presumed host galaxies. To separate out the light originating from the host object the authors remove the quasar contribution by scaling the point spread function (PSF). The PSF is a combination of an empirical PSF model, derived from stars lying in the same field as the quasars (used for the core of the PSF), and an analytical model for the wings of the PSF. After PSF subtraction of the QSO image the authors identify extended residual objects in 17 targets (nine in radio-loud and eight in radio-quiet quasars), of which a few are only marginal detections. These objects are large and luminous and their colours are relatively blue. Their V-R colours are consistent with a stellar population typical of late-type spirals and irregular galaxies. The blue colours could be caused by recent star formation events or by scattering of the QSO light
  • van Groningen, E., et al. (författare)
  • An algorithm for the relative scaling of spectra
  • 1992
  • Ingår i: Publications of the Astronomical Society of the Pacific. - 0004-6280 .- 1538-3873. ; 104:678, s. 700-703703
  • Tidskriftsartikel (refereegranskat)abstract
    • A method is described for the automatic relative scaling of spectra in which one or more lines with constant flux are present. The algorithm takes into account differences in spectral resolution, flux factors, and spectral shifts. It was developed for the relative calibration of series of optical spectra obtained in variability studies of active galactic nuclei but it also can be used for other purposes, e.g., the subtraction of an underlying stellar continuum in AGN with a template spectrum. Tests show that a high degree of accuracy is obtained, and that the method is superior to scaling the spectra by eye or measuring narrow-band fluxes
  • van Kuilenburg, Andre B. P., et al. (författare)
  • Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS
  • 2019
  • Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 380:15, s. 1433-1441
  • Tidskriftsartikel (refereegranskat)abstract
    • We report an inborn error of metabolism caused by an expansion of a GCA-repeat tract in the 5′ untranslated region of the gene encoding glutaminase (GLS) that was identified through detailed clinical and biochemical phenotyping, combined with whole-genome sequencing. The expansion was observed in three unrelated patients who presented with an early-onset delay in overall development, progressive ataxia, and elevated levels of glutamine. In addition to ataxia, one patient also showed cerebellar atrophy. The expansion was associated with a relative deficiency of GLS messenger RNA transcribed from the expanded allele, which probably resulted from repeat-mediated chromatin changes upstream of the GLS repeat. Our discovery underscores the importance of careful examination of regions of the genome that are typically excluded from or poorly captured by exome sequencing.
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