SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wetterberg L.) "

Sökning: WFRF:(Wetterberg L.)

  • Resultat 11-20 av 74
  • Föregående 1[2]34567...8Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Johansson, V., et al. (författare)
  • Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
  • 2019
  • Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - 0940-1334.
  • Tidskriftsartikel (refereegranskat)abstract
    • Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. © 2019, The Author(s).
  •  
12.
  •  
13.
  •  
14.
  •  
15.
  • Rye, Phil D., et al. (författare)
  • A Novel Blood Test for the Early Detection of Alzheimer's Disease
  • 2011
  • Ingår i: Journal of Alzheimer's Disease. - IOS Press. - 1387-2877. ; 23:1, s. 121-129
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite a variety of testing approaches, it is often difficult to make an accurate diagnosis of Alzheimer's disease (AD), especially at an early stage of the disease. Diagnosis is based on clinical criteria as well as exclusion of other causes of dementia but a definitive diagnosis can only be made at autopsy. We have investigated the diagnostic value of a 96-gene expression array for detection of early AD. Gene expression analysis was performed on blood RNA from a cohort of 203 probable AD and 209 cognitively healthy age matched controls. A disease classification algorithm was developed on samples from 208 individuals (AD = 103; controls = 105) and was validated in two steps using an independent initial test set (n = 74; AD= 32; controls = 42) and another second test set (n = 130; AD= 68; controls = 62). In the initial analysis, diagnostic accuracy was 71.6 +/- 10.3%, with sensitivity 71.9 +/- 15.6% and specificity 71.4 +/- 13.7%. Essentially the same level of agreement was achieved in the two independent test sets. High agreement (24/30; 80%) between algorithm prediction and subjects with available cerebrospinal fluid biomarker was found. Assuming a clinical accuracy of 80%, calculations indicate that the agreement with underlying true pathology is in the range 85%-90%. These findings suggest that the gene expression blood test can aid in the diagnosis of mild to moderate AD, but further studies are needed to confirm these findings.
  •  
16.
  •  
17.
  •  
18.
  •  
19.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 74
  • Föregående 1[2]34567...8Nästa
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy