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Sökning: WFRF:(Zheng Jie)

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  • Adams, Charleen, et al. (författare)
  • Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.
  • 2018
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755.
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).MATERIALS AND METHODS: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PSA) screening for prostate cancer within the Prostate testing for cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium.RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (p <0.0014, multiple-testing threshold). These fell into four classes: i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); ii) fatty acids and ratios; iii) amino acids; iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal.CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.
  • Bentley, Amy R., et al. (författare)
  • Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
  • 2019
  • Ingår i: Nature Genetics. - Nature Publishing Group. - 1061-4036. ; 51:4, s. 636-
  • Tidskriftsartikel (refereegranskat)abstract
    • The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
  • Haycock, Philip C., et al. (författare)
  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
  • 2017
  • Ingår i: JAMA Oncology. - American Medical Association. - 2374-2437. ; 3:5, s. 636-651
  • Tidskriftsartikel (refereegranskat)abstract
    • IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
  • Liang, Jie, et al. (författare)
  • A Crystalline Mesoporous Germanate with 48-Ring Channels for CO2 Separation
  • 2015
  • Ingår i: Angewandte Chemie International Edition. - 1433-7851. ; 54:25, s. 7290-7294
  • Tidskriftsartikel (refereegranskat)abstract
    • One of the challenges in materials science has been to prepare crystalline inorganic compounds with mesopores. Although several design strategies have been developed to address the challenge, expansion of pore sizes in inorganic materials is more difficult compared to that for metal-organic frameworks. Herein, we designed a novel mesoporous germanate PKU-17 with 3D 48 x 16 x 16-ring channels by introducing two large building units (Ge-10 and Ge-7 clusters) into the same framework. The key for this design strategy is the selection of 2-propanolamine (MIPA), which serves as the terminal species to promote the crystallization of Ge-7 clusters. Moreover, it is responsible for the coexistence of Ge-10 and Ge-7 clusters. To our knowledge, the discovery of PKU-17 sets a new record in pore sizes among germanates. It is also the first germanate that exhibits a good selectivity toward CO2 over N-2 and CH4.
  • Liang, Jie, et al. (författare)
  • CHA-type zeolites with high boron content : Synthesis, structure and selective adsorption properties
  • 2014
  • Ingår i: Microporous and Mesoporous Materials. - 1387-1811. ; 194, s. 97-105
  • Tidskriftsartikel (refereegranskat)abstract
    • Borosilicate zeolites with CHA-type framework are synthesized hydrothermally by using N,N,N-trimethylcyclohexylammonium hydroxide as structure directing agent. The use of this cation induces an increase of boron content in the CHA-type zeolites, and the Si/B ratios of the as-synthesized samples is in the range of 11.8-6.9. Rietveld refinements of the calcinated samples reveal a contraction of unit cells with the increase of boron content, and the 8-ring opening window of cha cavity becomes narrower. B-11 MAS NMR shows that all the boron atoms are incorporated into the framework as tetrahedral BO4 units in the as-synthesized samples. The thermal stability of these CHA-type borosilicates decreases with the increase of boron content, and the framework can retain up to 800 degrees C. These borosilicates, with the BET surfaces of 583-632 m(2)/g, show a high adsorption capacity for H-2 at 77 K, 900 mmHg and a preferential adsorption for CO2 at 273 K. This selective adsorption property enables CHA-type borosilicates to be potential materials as CO2 adsorbent.
  • Liu, Yang, et al. (författare)
  • Defect State Assisted Z-scheme Charge Recombination in Bi2O2CO3/Graphene Quantum Dot Composites for Photocatalytic Oxidation of NO
  • 2020
  • Ingår i: ACS Applied Nano Materials. - The American Chemical Society (ACS). - 2574-0970. ; 3:1, s. 772-781
  • Tidskriftsartikel (refereegranskat)abstract
    • In this work, we explored the photoinduced charge carriers dynamics rationalizing the photocatalytic oxidation of NO over N-doped Bi2O2CO3/graphene quantum dots composites(N-BOC/GQDs) via time-resolved photoluminescence (TRPL). Under visible light illumination, only GQDs can be photoexcited and inject electrons to N-BOC within 0.5 ns. Under UV light irradiation, the interfacial Z-scheme heterojunction recombination between the electrons in N-BOC and holes in GQDs dominate the depopulation of excited states within 0.36 ns. Such efficient Z-scheme recombination regardless of the large energy difference (1.66 eV) is mediated by the interfacial oxygen vacany defect states characterized by both density functional theory calculations (DFT) and electron paramagnetic resonance (EPR) measurement. This finding provide a novel strategic view to improve the photocatalytic performance of the nanocomposite by interfacial engineering
  • Wen, Wanqing, et al. (författare)
  • Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
  • 2016
  • Ingår i: Scientific Reports. - Nature Publishing Group. - 2045-2322. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
  • Zhang, Guojie, et al. (författare)
  • Comparative genomics reveals insights into avian genome evolution and adaptation
  • 2014
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 346:6215, s. 1311-1320
  • Tidskriftsartikel (refereegranskat)abstract
    • Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion of repetitive elements, large segmental deletions, and gene loss. Avian genomes furthermore show a remarkably high degree of evolutionary stasis at the levels of nucleotide sequence, gene synteny, and chromosomal structure. Despite this pattern of conservation, we detected many non-neutral evolutionary changes in protein-coding genes and noncoding regions. These analyses reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.
  • Albrecht, Stefano V., et al. (författare)
  • Reports on the 2015 AAAI Workshop Series
  • 2015
  • Ingår i: The AI Magazine. - 0738-4602. ; 36:2, s. 90-101
  • Tidskriftsartikel (refereegranskat)abstract
    • AAAI's 2015 Workshop Program was held Sunday and Monday, January 25-26, 2015, at the Hyatt Regency Austin Hotel in Austin, Texas, USA. The AAAI-15 workshop program included 16 workshops covering a wide range of topics in artificial intelligence. Most workshops were held on a single day. The titles of the workshops included Algorithm Configuration; Artificial Intelligence and Ethics; Artificial Intelligence Applied to Assistive Technologies and Smart Environments; Artificial Intelligence for Cities; Artificial Intelligence for Transportation: Advice, Inter-activity, and Actor Modeling; Beyond the Turing Test; Computational Sustainability; Computer Poker and Imperfect Information; Incentive and Trust in E-Communities; Knowledge, Skill, and Behavior Transfer in Autonomous Robots; Learning for General Competency in Video Games; Multiagent Interaction without Prior Coordination; Planning, Search, and Optimization; Scholarly Big Data: AI Perspectives, Challenges, and Ideas; Trajectory-Based Behaviour Analytics; and World Wide Web and Public Health Intelligence.
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