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Sökning: WFRF:(Zheng Jie)

  • Resultat 51-58 av 58
  • Föregående 12345[6]
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  • Zheng, Hui, et al. (författare)
  • Exact Line-of-Sight Probability for Channel Modeling in Typical Indoor Environments
  • 2018
  • Ingår i: IEEE Antennas and Wireless Propagation Letters. - 1536-1225. ; 17:7, s. 1359-1362
  • Tidskriftsartikel (refereegranskat)abstract
    • The probability of line-of-sight (LOS) propagation is crucial for channel modeling and small-cell network evaluation. In this letter, by taking the layout of building structures into account, an analytical LOS probability model is proposed for typical indoor scenarios, which have rectangular rooms and corridors. The proposed model is validated through Monte Carlo simulations. Numerical results show that the proposed model estimates the network performance accurately and efficiently.
  • Zheng, Hou-Feng, et al. (författare)
  • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
  • 2015
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 526:7571, s. 112-
  • Tidskriftsartikel (refereegranskat)abstract
    • The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF <= 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants(1-8), as well as rare, population specific, coding variants(9). Here we identify novel non-coding genetic variants with large effects on BMD (n(total) = 53,236) and fracture (n(total) = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD8 (rs11692564(T), MAF51.6%, replication effect size510.20 s.d., P-meta = 2 x 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 x 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1cre/flox mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size +10.41 s.d., P-meta = 1 x 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
  • Zheng, Hui, et al. (författare)
  • The Analysis of Indoor Wireless Communications by a Blockage Model in Ultra-Dense Networks
  • 2019
  • Ingår i: IEEE Vehicular Technology Conference. - 15502252. ; 2018-August
  • Konferensbidrag (refereegranskat)abstract
    • In indoor environments, the performance of ultra-dense cellular networks is significantly affected by blockages, especially for ultra-high frequencies. However, previous works either ignore or simplify such effects for analysing the networks. On the basis of stochastic geometry, this paper proposes a mathematically tractable approach to analyse ultra-dense networks in indoors, which considers both the effects of wall blockages and the distance-based path loss. The effects of wall blockages are firstly investigated by modelling the walls as a Boolean scheme of straight lines on a finite plane. Then a path loss model incorporating both the blockage-based and distance-based path loss is applied to analyse the performance of indoor networks. Finally, the analytical result is validated by comparing it with Monte Carlo simulations. The simulation results also show that the optimum transmitter density is finite for indoor ultra-dense networks with blockages, although the coverage probability benefits from the increase of transmitter density.
  • Zheng, Haoquan, et al. (författare)
  • Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs
  • 2015
  • Ingår i: Dalton Transactions. - 1477-9226. ; 44:46, s. 20186-20192
  • Tidskriftsartikel (refereegranskat)abstract
    • Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (similar to 25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexate (MTX) have been utilized as model drugs. The pH-responsive drug delivery system can be constructed based on electrostatic interactions between carriers and drug molecules. The UMSNs could store drugs under physiological conditions and release them under acidic conditions. Different pH-responsive release profiles were obtained in phosphate buffer solutions (PBSs) at the designed pH values (from 4.0 to 7.4). MX and DOX can be used in the pH-responsive delivery system, while MTX cannot be used. Furthermore, we found that the physiological stabilities of these drug molecules in UMSNs are in a decreasing order MX > DOX > MTX, which follows the order of their isoelectric point (pI) values.
  • Zheng, Jie, et al. (författare)
  • Carbide-metal phase interpenetrated double skeleton microstructures
  • 2000
  • Ingår i: 24th Annual Conference on Composites, Advanced Ceramics, Materials, and Structures : A: Ceramic Engineering and Science Proceedings, Volume 21, Issue 3. - Hoboken, NJ : John Wiley & Sons. - 9780470375686
  • Konferensbidrag (refereegranskat)abstract
    • Carbide-metal composites, such as Cr3C2-Cu, Cr3C2-bronze and TiC-Cu, were prepared by infiltrating liquid metal into carbide skeletons with open micro-porosity at high temperatures. X-ray diffraction and scanning electron microscopy equipped with energy dispersive spectrometry were used to characterize these materials. The resulting microstructures consisted of two interpenetrating three-dimensional skeletons. There is no sign of porosity at the interface indicating good wetting between the metal and ceramic. The combination of a ceramic and a metal in the composites resulted in unique combinations of mechanical and electrical properties. Abrasion and friction tests showed that the composite materials had better abrasion resistance than that of ceramics such as Al2O3 and SiC as well as lower friction coefficients than that of SiC. Tests in electrical contacts have revealed a contact resistance similar to copper. The composites are well suited for special applications, such as sliding electrical contacts, arc resistant switches, friction components and bearing/seal components.
  • Zheng, Wei, et al. (författare)
  • Divalent metal transporter 1 is involved in amyloid precursor protein processing and A{beta} generation.
  • 2009
  • Ingår i: FASEB Journal. - The Federation of American Societies for Experimental Biology. - 1530-6860. ; 23:12, s. 4207-4217
  • Tidskriftsartikel (refereegranskat)abstract
    • The amyloid-beta precursor protein (APP) and its pathogenic byproduct beta-amyloid peptide (Abeta) play central roles in the pathogenesis of Alzheimer's disease (AD). Reduction in levels of the potentially toxic Abeta is one of the most important therapeutic goals in AD. Recent studies have shown that bivalent metals such as iron, copper, and zinc are involved in APP expression, Abeta deposition, and senile plaque formation in the AD brain. However, the underlying mechanisms involved in abnormal homeostasis of bivalent metals in AD brain remain unclear. In the present study, we found that two isoforms of the divalent metal transporter 1 (DMT1), DMT1-IRE, and DMT1-nonIRE, were colocalized with Abeta in the plaques of postmortem AD brain. Using the APP/PS1 transgenic mouse model, we found that the levels of both DMT1-IRE and DMT1-nonIRE were significantly increased in the cortex and hippocampus compared with wild type-control. We further verified the proposed mechanisms by which DMT1 might be involved in APP processing and Abeta secretion by using the SH-SY5Y cell line stably overexpressing human APP Swedish mutation (APPsw) as a cell model. We found that overexpression of APPsw resulted in increased expression levels of both DMT1-IRE and DMT1-nonIRE in SH-SY5Y cells. Interestingly, silencing of endogenous DMT1 by RNA interference, which reduced bivalent ion influx, led to reductions of APP expression and Abeta secretion. These findings suggest both that DMT1 plays a critical role in ion-mediated neuropathogenesis in AD and that pharmacological blockage of DMT1 may provide novel therapeutic strategies against AD.-Zheng, W., Xin, N., Chi, Z.-H., Zhao, B.-L., Zhang, J., Li, J.-Y., Wang, Z.-Y. Divalent metal transporter 1 (DMT1) is involved in amyloid precursor protein processing and Abeta generation.
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  • Föregående 12345[6]
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