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- Akerstedt, Torbjorn, et al.
(författare)
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Predicting long-term sickness absence from sleep and fatigue.
- 2007
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Ingår i: J Sleep Res. - : Wiley. - 0962-1105 .- 1365-2869. ; 16:4, s. 341-5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Predicting long-term sickness absence from sleep and fatigue.Akerstedt T, Kecklund G, Alfredsson L, Selen J.Institute for Psychosocial Medicine, Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. torbjorn.akerstedt@ipm.ki.seDisturbed or shortened sleep is prospectively related to disease. One might also expect that sickness absence would be another consequence but very little data seem to exist. The present study used 8300 individuals in a national sample to obtain information on reports of disturbed sleep and fatigue 1 year and merged this with data on long-term sickness absence 2 years later. A logistic regression analysis was applied to the data with adjustments for demographic and work environment variables. The results showed that individuals without registered sickness absence at the start had a higher probability of entering a period of long-term (>/=90 days, odds ratio [OR] = 1.24 with 95% confidence interval [CI] = 1.02-1.51) sickness absence 2 years later if they reported disturbed sleep at the start. The figure for fatigue was OR = 1.35 (CI = 1.14-1.60). When fatigue or disturbed sleep was separately excluded the OR increased to OR = 1.44 and OR = 1.47, respectively. Intermediate sickness absence (14-89 days) showed similar but slightly weaker results. The results indicate that disturbed sleep and fatigue are predictors of long-term absence and it is suggested that impaired sleep may be part of a chain of causation, considering its effects on fatigue.PMID: 18036078 [PubMed - in process]
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| 2. |
- Arendt, Josephine, et al.
(författare)
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Clinical update : melatonin and sleep disorders.
- 2008
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Ingår i: Clin Med. - : Royal College of Physicians. - 1470-2118 .- 1473-4893. ; 8:4, s. 381-3
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Tidskriftsartikel (refereegranskat)abstract
- Clinical update: melatonin and sleep disorders.Arendt J, Van Someren EJ, Appleton R, Skene DJ, Akerstedt T.Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford. j.arendt@surrey.ac.ukThe hormone melatonin is increasingly used for the treatment of certain sleep disorders, particularly those related to disturbed biological rhythms. This article summarises current knowledge of its mechanism of action and identifies situations where there is good evidence for its efficacy. The authors provide advice, based on their own experience and consistent published data, concerning the dose range of melatonin to be used and the critically important question of the timing of treatment. Anecdotal evidence for the use of melatonin needs to be replaced by data from well-controlled, preferably multi-centre, randomised clinical trials.
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| 3. |
- Persson, Roger, et al.
(författare)
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Impact of an 84-hour workweek on biomarkers for stress, metabolic processes and diurnal rhythm
- 2006
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Ingår i: Scandinavian Journal of Work, Environment and Health. - 0355-3140. ; 32:5, s. 349-358
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Tidskriftsartikel (refereegranskat)abstract
- Objectives This study examined the degree to which long workhours in combination with an extended workweek (12 hours/7 days) with permanent day shifts (0700-1900), as requested by the workers, influenced biomarkers for stress, metabolic processes, and diurnal rhythm. Methods Construction workers (N=50) working 84 hours a week, with alternate weeks off, were compared with construction workers (N=25) having a traditional 40-hour work schedule. The participants were all male and between the ages of 21 to 65 years. Blood samples were obtained in the morning immediately prior to the start of work on workday 1, 5, and 7 to assess cholesterol, cortisol, dehydroepiandrosterone, melatonin, prolactin, testosterone, and uric acid. Psychosocial circumstances were assessed with a questionnaire. Results The 84-hour group had higher melatonin concentrations and reported higher job-control scores than the 40-hour group. For both groups, the melatonin, cortisol, and cholesterol concentrations were lower on workday 5 than on workday 1. In the 84-hour group, most of the biomarkers were significantly lower in concentrations on workday 7 than on workday 1. Only testosterone showed a significant decrease between workdays 5 and 7. The concentrations of dehydroepiandrosterone and uric acid remained stable across all of the days, as did the melatonin concentrations between workdays 5 and 7. Conclusions Working of one's own freewill on an 84-hour regimen is not, in the short-term, necessarily more harmful for health than working on a 40-hour regimen with a similar type of heavy worktasks. However, working on an 84-hour schedule beyond the ordinary 40-hour week results in signs of a functional shift in hormonal regulation.
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| 4. |
- Sagaspe, Patricia, et al.
(författare)
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Extended driving impairs nocturnal driving performances.
- 2008
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 31, s. A116-A116
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Tidskriftsartikel (refereegranskat)abstract
- Extended driving impairs nocturnal driving performances.Sagaspe P, Taillard J, Akerstedt T, Bayon V, Espié S, Chaumet G, Bioulac B, Philip P. GENPPHASS, CHU Pellegrin, Bordeaux, France.Though fatigue and sleepiness at the wheel are well-known risk factors for traffic accidents, many drivers combine extended driving and sleep deprivation. Fatigue-related accidents occur mainly at night but there is no experimental data available to determine if the duration of prior driving affects driving performance at night. Participants drove in 3 nocturnal driving sessions (3-5 am, 1-5 am and 9 pm-5 am) on open highway. Fourteen young healthy men (mean age [+/-SD] = 23.4 [+/-1.7] years) participated Inappropriate line crossings (ILC) in the last hour of driving of each session, sleep variables, self-perceived fatigue and sleepiness were measured. Compared to the short (3-5 am) driving session, the incidence rate ratio of inappropriate line crossings increased by 2.6 (95% CI, 1.1 to 6.0; P<.05) for the intermediate (1-5 am) driving session and by 4.0 (CI, 1.7 to 9.4; P<.001) for the long (9 pm-5 am) driving session. Compared to the reference session (9-10 pm), the incidence rate ratio of inappropriate line crossings were 6.0 (95% CI, 2.3 to 15.5; P<.001), 15.4 (CI, 4.6 to 51.5; P<.001) and 24.3 (CI, 7.4 to 79.5; P<.001), respectively, for the three different durations of driving. Self-rated fatigue and sleepiness scores were both positively correlated to driving impairment in the intermediate and long duration sessions (P<.05) and increased significantly during the nocturnal driving sessions compared to the reference session (P<.01). At night, extended driving impairs driving performances and therefore should be limited.
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