| 51. |
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| 52. |
- Andersson, Gustav, et al.
(författare)
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Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival : validatory study of two independent patient cohorts
- 2014
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Ingår i: BMC Urology. - : BioMed Central (BMC). - 1471-2490. ; 14:1, s. 36-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated with non-maintenance Bacillus Calmette-Guerin (n = 92), and the associations with adverse clinicopathological factors have been validated in another, unselected, cohort (n = 104). In the present study, we examined the prognostic significance of ezrin expression in urothelial bladder cancer in a total number of 442 tumours from two independent patient cohorts. Methods: Immunohistochemical expression of ezrin was evaluated in tissue microarrays with tumours from one retrospective cohort of bladder cancer (n = 110; cohort I) and one population-based cohort (n = 342; cohort II). Classification regression tree analysis was applied for selection of prognostic cutoff. Kaplan-Meier analysis, log rank test and Cox regression proportional hazards' modeling were used to evaluate the impact of ezrin on 5-year overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS). Results: Ezrin expression could be evaluated in tumours from 100 and 342 cases, respectively. In both cohorts, reduced membranous ezrin expression was significantly associated with more advanced T-stage (p < 0.001), high grade tumours (p < 0.001), female sex (p = 0.040 and p = 0.013), and membranous expression of podocalyxin-like protein (p < 0.001 and p = 0.009). Moreover, reduced ezrin expression was associated with a significantly reduced 5-year OS in both cohorts (HR = 3.09 95% CI 1.71-5.58 and HR = 2.15(1.51-3.06), and with DSS in cohort II (HR = 2.77, 95% CI 1.78-4.31). This association also remained significant in adjusted analysis in Cohort I (HR1.99, 95% CI 1.05-3.77) but not in Cohort II. In pTa and pT1 tumours in cohort II, there was no significant association between ezrin expression and time to progression. Conclusions: The results from this study validate previous findings of reduced membranous ezrin expression in urothelial bladder cancer being associated with unfavourable clinicopathological characteristics and an impaired survival. The utility of ezrin as a prognostic biomarker in transurethral resection specimens merits further investigation.
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| 53. |
- Andersson, Hanna, 1979, et al.
(författare)
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Assessing the Ability of Spectroscopic Methods to Determine the Difference in the Folding Propensities of Highly Similar beta-Hairpins
- 2017
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Ingår i: Acs Omega. - : American Chemical Society (ACS). - 2470-1343. ; 2:2, s. 508-516
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Tidskriftsartikel (refereegranskat)abstract
- We have evaluated the ability of nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopies to describe the difference in the folding propensities of two structurally highly similar cyclic beta-hairpins, comparing the outcome to that of molecular dynamics simulations. NAMFIS-type NMR ensemble analysis and CD spectroscopy were observed to accurately describe the consequence of altering a single interaction site, whereas a single-site C-13 NMR chemical shift melting curve-based technique was not.
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| 54. |
- Andersson, Helene, et al.
(författare)
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Experiences of sensory input in daily occupations for people with serious mental illness
- 2021
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Ingår i: Scandinavian Journal of Occupational Therapy. - : Informa UK Limited. - 1103-8128 .- 1651-2014. ; 28:6, s. 446-456
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is growing evidence that people with serious mental illness have impaired capacity for processing sensory inputs which affects daily occupation. Although this is known, research regarding the target groups experiences of sensory inputs in daily occupations is lacking. Aim: To investigate the experience of sensory input and strategies used in daily occupations among people with serious mental illness. Material and methods: Fourteen people with serious mental illness were interviewed regarding their experiences of sensory processing and strategies for managing sensory inputs in daily occupations. Data were analysed using content analysis. Results: Sensory processing issues affected occupational engagement and strategies to control inputs were intuitively used to cope with sensory challenges. Informants either ignored, reduced or avoided sensory inputs. Informants also enabled daily life through strategies such as creating a home that provides rest, finding a safe place, using nature and animals for relaxing and using effects of calming and alerting occupations. Discussion: Specific sensory inputs were difficult to process, which was experienced as stressful and affected occupations negatively. The results imply a need for further research exploring the management of sensory input and the use of sensory modulation approaches to enable engagement in daily activities.
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| 55. |
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| 56. |
- Andersson, Hanna, 1979, et al.
(författare)
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Solvent Effects on Nitrogen Chemical Shifts
- 2015
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Ingår i: Annual Reports on NMR Spectroscopy. - : Elsevier. - 0066-4103. - 9780128021231 ; 86, s. 73-210
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Forskningsöversikt (refereegranskat)abstract
- Due to significant developments in cryogenic probe technology and the easy access to inverse detection pulse programmes (HSQC, HMBC), the sensitivity of nitrogen NMR has lately vastly improved. As a consequence, nitrogen NMR has turned into a useful and commonly available tool for solution studies of molecular structure and properties for small organic compounds likewise biopolymers. The high sensitivity of the nitrogen lone pair to changes in the molecular environment, alterations in intra- and intermolecular interactions, and in molecular conformation along with its wide, up to 1200 ppm chemical shift dispersion make nitrogen NMR to an exceptionally sensitive reporter tool. The nitrogen chemical shift has been applied in various fields of chemistry, including for instance the studies of transition metal complexes, chemical reactions such as N-alkylation and N-oxidation, tautomerization, protonation–deprotonation equilibria, hydrogen and halogen bonding, and elucidation of molecular conformation and configuration. The 15N NMR data observed in the investigation of these molecular properties and processes is influenced by the medium it is acquired in. This influence may be due to direct coordination of solvent molecules to transition metal complexes, alteration of tautomerization equilibria, and solvent polarity induced electron density changes of conjugated systems, for example. Thus, the solvent may significantly alter the observed nitrogen NMR shifts. This review aims to provide an overview of solvent effects of practical importance, and discusses selected experimental reports from various subfields of chemistry.
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| 57. |
- Andersson Hval, Ulrika, 1974-, et al.
(författare)
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Klimatkrisen i klassrummet : Reflektioner kring användning av litteratur i undervisning om hållbar utveckling
- 2021
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Ingår i: Utbildning och Lärande / Education and Learning. - Falun : Högskolan Dalarna. - 2001-4554. ; :2, s. 27-44
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Tidskriftsartikel (refereegranskat)abstract
- This study shows how climate fiction can offer pedagogical opportunities for encouraging student agency as well as open up constructive discussions about the future in relation to social change and climate justice. In order to test a practical opportunity for such a productive conversation, and to draw out its didactic implications, Swedish teacher trainee students were asked to participate in a group discussion on how climate fiction may be used in the teaching of sustainability in upper secondary school. Specifically, they were requested to contribute to the framing and organization of the discussion of a work of climate fiction, The Marrow Thieves by Cherie Dimaline, but they were also asked to reflect on social dimensions of teaching about the climate crisis, such as climate psychology, democracy issues, equality and existential questions. Drawing on the students’ discernments in the discussion, the study finds that insights from climate psychology concerning the importance of problem-focused and meaning-focused coping strategies to handle negative emotions such as worry, fear and hopelessness are relevant for literature didactics.
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| 58. |
- Andersson Hval, Ulrika, 1974-
(författare)
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New Zealand/Aotearoa : Choosing an Identity
- 2013. - 1. uppl.
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Ingår i: Postcolonial texts and events. - Lund. - 9789144070698 ; , s. 261-292
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 59. |
- Andersson Hval, Ulrika, 1974-, et al.
(författare)
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The Immigrant Girl and the Western Boyfriend : The Romance Plot in Young Adult Novels of Migration
- 2016
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Ingår i: ESSE messenger. - : European Society for the Study of English. - 2518-3567. ; 25:1, s. 122-132
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Tidskriftsartikel (refereegranskat)abstract
- We explore a recurring motif in a number of young adult novels centered around the experiences of immigrant girls and their adjustment to life in a new country. The integration process appears to belinked to the girls’ relationships with boys from the majority culture, making romance a central element of the girls’ development of a new identity and sense of belonging in the new country. We will examine the intersections of gender and integration by focusing on the narrative voices of immigrant girls in three contemporary novels, Sarah Darer Littman’s Life, After (2010), Sarah Crossan’s The Weight of Water(2012), and Terry Farish’s The Good Braider (2012).
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| 60. |
- Andersson Hval, Ulrika, 1974-
(författare)
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The Superhero and the Tiger Mom : Examining the Relation Between Parental Expectations and Career Choices in Gene Luen Yang and Sonny Liew’s The Shadow Hero
- 2021
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Ingår i: Engaging with Work in English Studies. - Cham : Springer Berlin/Heidelberg. - 9783030697198 - 9783030697204 ; , s. 127-150
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Bokkapitel (refereegranskat)abstract
- Through the example of Gene Luen Yang and Sonny Liew’s The Shadow Hero (2014), this chapter interrogates the cultural clashes emerging from the discrepancy between individualist and collectivist views of work in relation to family and society. While classic superhero narratives can be understood as manifestations of individualism, this narrative presents a young hero who is pushed into the role by an overzealous mother, reminiscent of the Tiger Mother-figure of Amy Chua’s controversial autobiography (Battle Hymn of the Tiger Mother, Penguin, 2011). Applying theories from social psychology to the analysis, it is shown that the idea of the independent self, in which work is a mark of adult autonomy, is posited against an idea of the self as interdependent and associated with collectivist ideals that link work with family and prioritize filial piety.
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