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Träfflista för sökning "WFRF:(Backlund L) "

Search: WFRF:(Backlund L)

  • Result 111-120 of 131
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  • Nordstrom, EA, et al. (author)
  • A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity
  • 2005
  • In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:6, s. 1726-1734
  • Journal article (peer-reviewed)abstract
    • Elevated circulating fatty acid concentration is a hallmark of insulin resistance and is at least in part attributed to the action of adipose tissue-derived tumor necrosis factor-α (TNF-α) on lipolysis. Cell death-inducing DFFA (DNA fragmentation factor-α)-like effector A (CIDEA) belongs to a family of proapoptotic proteins that has five known members in humans and mice. The action of CIDEA is unknown, but CIDEA-null mice are resistant to obesity and diabetes. We investigated CIDEA in adipose tissue of obese and lean humans and mice. The mRNA was expressed in white human fat cells and in brown mouse adipocytes. The adipose mRNA expression of CIDEA in mice was not influenced by obesity. However, CIDEA expression was decreased twofold in obese humans and normalized after weight reduction. Low adipose CIDEA expression was associated with several features of the metabolic syndrome. Human adipocyte depletion of CIDEA by RNA interference stimulated lipolysis and increased TNF-α secretion by a posttranscriptional effect. Conversely, TNF-α treatment decreased adipocyte CIDEA expression via the mitogen-activated protein kinase c-Jun NH2-terminal kinase. We propose an important and human-specific role for CIDEA in lipolysis regulation and metabolic complications of obesity, which is at least in part mediated by cross-talk between CIDEA and TNF-α.
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  • Strawbridge, RJ, et al. (author)
  • Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness
  • 2016
  • In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 65:10, s. 2888-2899
  • Journal article (peer-reviewed)abstract
    • Type 2 diabetes and cardiovascular disease are complex disorders involving metabolic and inflammatory mechanisms. Here we investigated whether sCD93, a group XIV c-type lectin of the endosialin family, plays a role in metabolic dysregulation or carotid intima-media thickness (IMT). Although no association was observed between sCD93 and IMT, sCD93 levels were significantly lower in subjects with type 2 diabetes (n = 901, mean ± SD 156.6 ± 40.0 ng/mL) compared with subjects without diabetes (n = 2,470, 164.1 ± 44.8 ng/mL, P < 0.0001). Genetic variants associated with diabetes risk (DIAGRAM Consortium) did not influence sCD93 levels (individually or combined in a single nucleotide polymorphism score). In a prospective cohort, lower sCD93 levels preceded the development of diabetes. Consistent with this, a cd93-deficient mouse model (in addition to apoe deficiency) demonstrated no difference in atherosclerotic lesion development compared with apoe−/− cd93-sufficient littermates. However, cd93-deficient mice showed impaired glucose clearance and insulin sensitivity (compared with littermate controls) after eating a high-fat diet. The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases. We further demonstrated that stress-induced release of sCD93 is impaired by hyperglycemia. Therefore, we propose CD93 as an important component in glucometabolic regulation.
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  • Result 111-120 of 131
Type of publication
journal article (94)
conference paper (35)
other publication (2)
Type of content
peer-reviewed (90)
other academic/artistic (41)
Author/Editor
Backlund, L (58)
Schalling, M (35)
Landén, Mikael, 1966 (29)
Lavebratt, C (29)
OSBY, U (23)
Martinsson, L. (22)
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Frisen, L. (21)
Bellivier, F. (18)
Reif, A. (18)
Maegdefessel, L (17)
Cichon, S (17)
Rietschel, M (17)
Bauer, M (17)
Etain, B. (17)
Jamain, S. (17)
Jin, H. (15)
Degenhardt, F (15)
Backlund, LM (15)
Leboyer, M. (15)
Liu, L. (14)
Grigoroiu-Serbanescu ... (14)
Herms, S. (14)
Kittel-Schneider, S. (14)
Alda, M. (14)
Collins, VP (14)
Hauser, J. (13)
Turecki, G. (13)
Vieta, E (12)
Heilbronner, U. (12)
Cervantes, P. (12)
Cruceanu, C. (12)
Hoffmann, P (11)
Mattheisen, M (11)
McMahon, FJ (11)
Schulze, TG (11)
Millischer, V (11)
Pfennig, A. (11)
Schalling, Martin (10)
Backlund, Lena (10)
Ardau, R. (10)
Chillotti, C. (10)
Del Zompo, M. (10)
Manchia, M. (10)
Monteleone, P. (10)
O'Donovan, C. (10)
Severino, G. (10)
Squassina, A. (10)
Maj, M. (10)
Frank, J (10)
Potash, JB (10)
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University
Karolinska Institutet (117)
University of Gothenburg (31)
Uppsala University (8)
Umeå University (4)
Lund University (3)
Högskolan Dalarna (3)
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Linköping University (2)
Royal Institute of Technology (1)
Stockholm University (1)
Mid Sweden University (1)
RISE (1)
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Language
English (130)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (38)
Natural sciences (3)
Engineering and Technology (2)
Social Sciences (1)

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