| 21. |
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| 22. |
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| 23. |
- Claeyssens, A., et al.
(författare)
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Spectral variations of Lyman alpha emission within strongly lensed sources observed with MUSE
- 2019
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 489:4, s. 5022-5029
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Tidskriftsartikel (refereegranskat)abstract
- We present an analysis of HI Lyman alpha emission in deep VLT/MUSE observations of two highly magnified and extended galaxies at z = 3.5 and 4.03, including a newly discovered, almost complete Einstein ring. While these Lyman a haloes are intrinsically similar to the ones typically seen in other MUSE deep fields, the benefits of gravitational lensing allow us to construct exceptionally detailed maps of Lyman alpha line properties at sub-kpc scales. By combining all multiple images, we are able to observe complex structures in the Lyman a emission and uncover small (similar to 120 km s(-1) in Lyman alpha peak shift), but significant at >4 sigma, systematic variations in the shape of the Lyman a line profile within each halo. Indeed, we observe a global trend for the line peak shift to become redder at large radii, together with a strong correlation between the peak wavelength and line width. This systematic intrahalo variation is markedly similar to the object-to-object variations obtained from the integrated properties of recent large samples. Regions of high surface brightness correspond to relatively small line shifts, which could indicate that Lyman alpha emission escapes preferentially from regions where the line profile has been less severely affected by scattering of Lyman alpha photons.
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| 24. |
- Diener, C., et al.
(författare)
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The MUSE-Wide survey : detection of a clustering signal from Lyman alpha emitters in the range 3 < z < 6
- 2017
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 471:3, s. 3186-3192
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Tidskriftsartikel (refereegranskat)abstract
- We present a clustering analysis of a sample of 238 Ly alpha emitters at redshift 3 less than or similar to z less than or similar to 6 from the MUSE-Wide survey. This survey mosaics extragalactic legacy fields with 1h MUSE pointings to detect statistically relevant samples of emission line galaxies. We analysed the first year observations from MUSE-Wide making use of the clustering signal in the line-of-sight direction. This method relies on comparing pair-counts at close redshifts for a fixed transverse distance and thus exploits the full potential of the redshift range covered by our sample. A clear clustering signal with a correlation length of r(0) = 2.9(-1.1)(+1.0) Mpc (comoving) is detected. Whilst this result is based on only about a quarter of the full survey size, it already shows the immense potential of MUSE for efficiently observing and studying the clustering of Ly alpha emitters.
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| 25. |
- Drake, A. B., et al.
(författare)
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The MUSE Hubble Ultra Deep Field Survey VI. The faint-end of the Lyα luminosity function at 2.91
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 608
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Tidskriftsartikel (refereegranskat)abstract
- We present the deepest study to date of the Ly alpha luminosity function in a blank field using blind integral field spectroscopy from MUSE. We constructed a sample of 604 Ly alpha emitters (LAEs) across the redshift range 2.91 < z < 6.64 using automatic detection software in the Hubble Ultra Deep Lield. The deep data cubes allowed us to calculate accurate total Ly alpha fluxes capturing low surface-brightness extended Ly alpha emission now known to be a generic property of high-redshift star-forming galaxies. We simulated realistic extended LAEs to fully characterise the selection function of our samples, and performed flux-recovery experiments to test and correct for bias in our determination of total Ly alpha fluxes. We find that an accurate completeness correction accounting for extended emission reveals a very steep faint-end slope of the luminosity function, alpha, down to luminosities of log(10) L erg s(-1) < 41.5, applying both the 1/V-max and maximum likelihood estimators. Splitting the sample into three broad redshift bins, we see the faint-end slope increasing from -2.03(-0.07)(+1.42) at z approximate to 3.44 to -2.86(-infinity)(+0.76) Z approximate to 76 at z approximate to 5.48, however no strong evolution is seen between the 68% confidence regions in L*-alpha parameter space. Using the Ly alpha line flux as a proxy for star formation activity, and integrating the observed luminosity functions, we find that LAEs' contribution to the cosmic star formation rate density rises with redshift until it is comparable to that from continuum-selected samples by z approximate to 6. This implies that LAEs may contribute more to the star-formation activity of the early Universe than previously thought, as any additional intergalactic medium (IGM) correction would act to further boost the Ly alpha luminosities. Linally, assuming fiducial values for the escape of Ly alpha and LyC radiation, and the dumpiness of the IGM, we integrated the maximum likelihood luminosity function at 5.00 < z < 6.64 and find we require only a small extrapolation beyond the data (<1 dex in luminosity) for LAEs alone to maintain an ionised IGM at z approximate to 6.
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| 26. |
- Solomon, A., et al.
(författare)
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Freshwater in the Arctic Ocean 2010-2019
- 2021
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Ingår i: Ocean Science. - : Copernicus GmbH. - 1812-0784 .- 1812-0792. ; 17:4, s. 1081-1102
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Tidskriftsartikel (refereegranskat)abstract
- U The Arctic climate system is rapidly transitioning into a new regime with a reduction in the extent of sea ice, enhanced mixing in the ocean and atmosphere, and thus enhanced coupling within the ocean-ice-atmosphere system; these physical changes are leading to ecosystem changes in the Arctic Ocean. In this review paper, we assess one of the critically important aspects of this new regime, the variability of Arctic freshwater, which plays a fundamental role in the Arctic climate system by impacting ocean stratification and sea ice formation or melt. Liquid and solid freshwater exports also affect the global climate system, notably by impacting the global ocean overturning circulation. We assess how freshwater budgets have changed relative to the 2000-2010 period. We include discussions of processes such as poleward atmospheric moisture transport, runoff from the Greenland Ice Sheet and Arctic glaciers, the role of snow on sea ice, and vertical redistribution. Notably, sea ice cover has become more seasonal and more mobile; the mass loss of the Greenland Ice Sheet increased in the 2010s (particularly in the western, northern, and southern regions) and imported warm, salty Atlantic waters have shoaled. During 2000-2010, the Arctic Oscillation and moisture transport into the Arctic are in-phase and have a positive trend. This cyclonic atmospheric circulation pattern forces reduced freshwater content on the Atlantic-Eurasian side of the Arctic Ocean and freshwater gains in the Beaufort Gyre. We show that the trend in Arctic freshwater content in the 2010s has stabilized relative to the 2000s, potentially due to an increased compensation between a freshening of the Beaufort Gyre and a reduction in freshwater in the rest of the Arctic Ocean. However, large intermodel spread across the ocean reanalyses and uncertainty in the observations used in this study prevent a definitive conclusion about the degree of this compensation.
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| 27. |
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| 28. |
- Toksvang, LN, et al.
(författare)
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Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
- 2022
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Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 22:1, s. 483-
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundA critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase is essential in relapse prevention. The Thiopurine Enhanced ALL Maintenance (TEAM) trial investigates a novel strategy for ALL maintenance.MethodsTEAM is a randomized phase 3 sub-protocol to the ALLTogether1 trial, which includes patients 0–45 years of age with newly diagnosed B-cell precursor or T-cell ALL, and stratified to the intermediate risk-high (IR-high) group, in 13 European countries. In the TEAM trial, the traditional methotrexate (MTX)/6-mercaptopurine (6MP) maintenance backbone (control arm) is supplemented with low dose (2.5–12.5 mg/m2/day) oral 6-thioguanine (6TG) (experimental arm), while the starting dose of 6MP is reduced from 75 to 50 mg/m2/day. A total of 778 patients will be included in TEAM during ~ 5 years. The study will close when the last included patient has been followed for 5 years from the end of induction therapy. The primary objective of the study is to significantly improve the disease-free survival (DFS) of IR-high ALL patients by adding 6TG to 6MP/MTX-based maintenance therapy. TEAM has 80% power to detect a 7% increase in 5-year DFS through a 50% reduction in relapse rate. DFS will be evaluated by intention-to-treat analysis. In addition to reducing relapse, TEAM may also reduce hepatotoxicity and hypoglycemia caused by high levels of methylated 6MP metabolites. Methotrexate/6MP metabolites will be monitored and low levels will be reported back to clinicians to identify potentially non-adherent patients.DiscussionTEAM provides a novel strategy for maintenance therapy in ALL with the potential of improving DFS through reducing relapse rate. Potential risk factors that have been considered include hepatic sinusoidal obstruction syndrome/nodular regenerative hyperplasia, second cancer, infection, and osteonecrosis. Metabolite monitoring can potentially increase treatment adherence in both treatment arms.Trial registrationEudraCT, 2018–001795-38. Registered 2020-05-15,Clinicaltrials.gov,NCT04307576. Registered 2020-03-13,https://clinicaltrials.gov/ct2/show/NCT04307576
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| 29. |
- Wisotzki, L., et al.
(författare)
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Nearly all the sky is covered by Lyman-alpha emission around high-redshift galaxies
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 562:7726, s. 229-232
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Tidskriftsartikel (refereegranskat)abstract
- Galaxies are surrounded by large reservoirs of gas, mostly hydrogen, that are fed by inflows from the intergalactic medium and by outflows from galactic winds. Absorption-line measurements along the lines of sight to bright and rare background quasars indicate that this circumgalactic medium extends far beyond the starlight seen in galaxies, but very little is known about its spatial distribution. The Lyman-alpha transition of atomic hydrogen at a wavelength of 121.6 nanometres is an important tracer of warm (about 104 kelvin) gas in and around galaxies, especially at cosmological redshifts greater than about 1.6 at which the spectral line becomes observable from the ground. Tracing cosmic hydrogen through its Lyman-a emission has been a long-standing goal of observational astrophysics(1-3), but the extremely low surface brightness of the spatially extended emission is a formidable obstacle. A new window into circumgalactic environments was recently opened by the discovery of ubiquitous extended Lyman-alpha emission from hydrogen around high-redshift galaxies(4,5). Such measurements were previously limited to especially favourable systems(6-8) or to the use of massive statistical averaging(9,10) because of the faintness of this emission. Here we report observations of low-surface-brightness Lyman-alpha emission surrounding faint galaxies at redshifts between 3 and 6. We find that the projected sky coverage approaches 100 per cent. The corresponding rate of incidence (the mean number of Lyman-alpha emitters penetrated by any arbitrary line of sight) is well above unity and similar to the incidence rate of high-column-density absorbers frequently detected in the spectra of distant quasars(11-14). This similarity suggests that most circumgalactic atomic hydrogen at these redshifts has now been detected in emission.
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| 30. |
- Antonelli, Alexandre, 1978, et al.
(författare)
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Madagascar's extraordinary biodiversity : Evolution, distribution, and use
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 378:6623, s. 962-
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Tidskriftsartikel (refereegranskat)abstract
- Madagascar's biota is hyperdiverse and includes exceptional levels of endemicity. We review the current state of knowledge on Madagascar's past and current terrestrial and freshwater biodiversity by compiling and presenting comprehensive data on species diversity, endemism, and rates of species description and human uses, in addition to presenting an updated and simplified map of vegetation types. We report a substantial increase of records and species new to science in recent years; however, the diversity and evolution of many groups remain practically unknown (e.g., fungi and most invertebrates). Digitization efforts are increasing the resolution of species richness patterns and we highlight the crucial role of field- and collections-based research for advancing biodiversity knowledge and identifying gaps in our understanding, particularly as species richness corresponds closely to collection effort. Phylogenetic diversity patterns mirror that of species richness and endemism in most of the analyzed groups. We highlight humid forests as centers of diversity and endemism because of their role as refugia and centers of recent and rapid radiations. However, the distinct endemism of other areas, such as the grassland-woodland mosaic of the Central Highlands and the spiny forest of the southwest, is also biologically important despite lower species richness. The documented uses of Malagasy biodiversity are manifold, with much potential for the uncovering of new useful traits for food, medicine, and climate mitigation. The data presented here showcase Madagascar as a unique " living laboratory" for our understanding of evolution and the complex interactions between people and nature. The gathering and analysis of biodiversity data must continue and accelerate if we are to fully understand and safeguard this unique subset of Earth's biodiversity.
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