| 11. |
- Athron, Peter, et al.
(författare)
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Global fits of GUT-scale SUSY models with GAMBIT
- 2017
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:12
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Tidskriftsartikel (refereegranskat)abstract
- We present the most comprehensive global fits to date of three supersymmetric models motivated by grand unification: the Constrained Minimal Supersymmetric Standard Model (CMSSM), and its Non-Universal Higgs Mass generalisations NUHM1 and NUHM2. We include likelihoods from a number of direct and indirect dark matter searches, a large collection of electroweak precision and flavour observables, direct searches for supersymmetry at LEP and Runs I and II of the LHC, and constraints from Higgs observables. Our analysis improves on existing results not only in terms of the number of included observables, but also in the level of detail with which we treat them, our sampling techniques for scanning the parameter space, and our treatment of nuisance parameters. We show that stau co-annihilation is now ruled out in the CMSSM at more than 95% confidence. Stop co-annihilation turns out to be one of the most promising mechanisms for achieving an appropriate relic density of darkmatter in all threemodels, whilst avoiding all other constraints. We find high-likelihood regions of parameter space featuring light stops and charginos, making them potentially detectable in the near future at the LHC. We also show that tonne-scale direct detection will play a largely complementary role, probing large parts of the remaining viable parameter space, including essentially all models with multi-TeV neutralinos.
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| 12. |
- Athron, Peter, et al.
(författare)
-
SpecBit, DecayBit and PrecisionBit : GAMBIT modules for computing mass spectra, particle decay rates and precision observables
- 2018
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:1
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Tidskriftsartikel (refereegranskat)abstract
- We present the GAMBIT modules SpecBit, DecayBit and PrecisionBit. Together they provide a new framework for linking publicly available spectrum generators, decay codes and other precision observable calculations in a physically and statistically consistent manner. This allows users to automatically run various combinations of existing codes as if they are a single package. The modular design allows software packages fulfilling the same role to be exchanged freely at runtime, with the results presented in a common format that can easily be passed to downstream dark matter, collider and flavour codes. These modules constitute an essential part of the broader GAMBIT framework, a major new software package for performing global fits. In this paper we present the observable calculations, data, and likelihood functions implemented in the three modules, as well as the conventions and assumptions used in interfacing them with external codes. We also present 3-BIT-HIT, a command-line utility for computing mass spectra, couplings, decays and precision observables in the MSSM, which shows how the three modules can easily be used independently of GAMBIT.
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| 13. |
- Athron, Peter, et al.
(författare)
-
Status of the scalar singlet dark matter model
- 2017
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:8
-
Tidskriftsartikel (refereegranskat)abstract
- One of the simplest viable models for dark matter is an additional neutral scalar, stabilised by a symmetry. Using the GAMBIT package and combining results from four independent samplers, we present Bayesian and frequentist global fits of this model. We vary the singlet mass and coupling along with 13 nuisance parameters, including nuclear uncertainties relevant for direct detection, the local dark matter density, and selected quark masses and couplings. We include the dark matter relic density measured by Planck, direct searches with LUX, PandaX, SuperCDMS and XENON100, limits on invisible Higgs decays from the Large Hadron Collider, searches for high-energy neutrinos from dark matter annihilation in the Sun with IceCube, and searches for gamma rays from annihilation in dwarf galaxies with the Fermi-LAT. Viable solutions remain at couplings of order unity, for singlet masses between the Higgs mass and about 300 GeV, and at masses above 1 TeV. Only in the latter case can the scalar singlet constitute all of dark matter. Frequentist analysis shows that the low-mass resonance region, where the singlet is about half the mass of the Higgs, can also account for all of dark matter, and remains viable. However, Bayesian considerations show this region to be rather fine-tuned.
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| 14. |
- Balázs, Csaba, et al.
(författare)
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ColliderBit : a GAMBIT module for the calculation of high-energy collider observables and likelihoods
- 2017
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
-
Tidskriftsartikel (refereegranskat)abstract
- We describe ColliderBit, a new code for the calculation of high energy collider observables in theories of physics beyond the Standard Model (BSM). ColliderBit features a generic interface to BSM models, a unique parallelised Monte Carlo event generation scheme suitable for large-scale supercomputer applications, and a number of LHC analyses, covering a reasonable range of the BSM signatures currently sought by ATLAS and CMS. ColliderBit also calculates likelihoods for Higgs sector observables, and LEP searches for BSM particles. These features are provided by a combination of new code unique to ColliderBit, and interfaces to existing state-of-the-art public codes. ColliderBit is both an important part of the GAMBIT framework for BSM inference, and a standalone tool for efficiently applying collider constraints to theories of new physics.
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| 15. |
- Balázs, Csaba, et al.
(författare)
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Cosmological constraints on decaying axion-like particles : a global analysis
- 2022
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :12
-
Tidskriftsartikel (refereegranskat)abstract
- Axion-like particles (ALPs) decaying into photons are known to affect a wide range of astrophysical and cosmological observables. In this study we focus on ALPs with masses in the keV–MeV range and lifetimes between 104 and 1013 seconds, corresponding to decays between the end of Big Bang Nucleosynthesis and the formation of the Cosmic Microwave Background (CMB). Using the CosmoBit module of the global fitting framework GAMBIT, we combine state-of-the-art calculations of the irreducible ALP freeze-in abundance, primordial element abundances (including photodisintegration through ALP decays), CMB spectral distortions and anisotropies, and constraints from supernovae and stellar cooling. This approach makes it possible for the first time to perform a global analysis of the ALP parameter space while varying the parameters of ΛCDM as well as several nuisance parameters. We find a lower bound on the ALP mass of around ma > 300 keV, which can only be evaded if ALPs are stable on cosmological timescales. Future observations of CMB spectral distortions with a PIXIE-like mission are expected to improve this bound by two orders of magnitude.
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| 16. |
- Balazs, Csaba, et al.
(författare)
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Interpreting the Fermi-LAT gamma ray excess in the simplified framework
- 2015
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Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 92:12
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Tidskriftsartikel (refereegranskat)abstract
- We test the plausibility of the hypothesis that the annihilation of a Majorana fermion dark matter particle via a scalar mediator explains the gamma ray excess from the Galactic center. Assuming that the mediator couples to all third generation fermions we calculate observables for dark matter abundance and scattering on nuclei, gamma, positron, and antiproton cosmic ray fluxes, radio emission from dark matter annihilation, and the effect of dark matter annihilations on the CMB. After discarding the controversial radio observation, we show that the dark matter model simultaneously fits the observed excesses in the cosmic gamma ray, the positron, and antiproton fluxes, while evading constraints from the CMB and direct detection. The experimental data are consistent with a dark matter (mediator) mass in the 10-100 (3-1000) GeV region and with weakly correlated couplings to bottom quarks and tau leptons with values of 10(-3) - 1 at the 68% credibility level.
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| 17. |
- Balázs, Csaba, et al.
(författare)
-
Sensitivity of the Cherenkov Telescope Array to the detection of a dark matter signal in comparison to direct detection and collider experiments
- 2017
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:8
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Tidskriftsartikel (refereegranskat)abstract
- Imaging atmospheric Cherenkov telescopes (IACTs) that are sensitive to potential.-ray signals from dark matter (DM) annihilation above similar to 50 GeV will soon be superseded by the Cherenkov Telescope Array (CTA). CTA will have a point source sensitivity an order of magnitude better than currently operating IACTs and will cover a broad energy range between 20 GeV and 300 TeV. Using effective field theory and simplified models to calculate gamma-ray spectra resulting from DM annihilation, we compare the prospects to constrain such models with CTA observations of the Galactic center with current and near-future measurements at the Large Hadron Collider (LHC) and direct detection experiments. For DM annihilations via vector or pseudoscalar couplings, CTA observations will be able to probe DM models out of reach of the LHC, and, if DM is coupled to standard fermions by a pseudoscalar particle, beyond the limits of current direct detection experiments.
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| 18. |
- Balint, Monika, et al.
(författare)
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Binding Networks Identify Targetable Protein Pockets for Mechanism-Based Drug Design
- 2022
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:13
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Tidskriftsartikel (refereegranskat)abstract
- The human genome codes only a few thousand druggable proteins, mainly receptors and enzymes. While this pool of available drug targets is limited, there is an untapped potential for discovering new drug-binding mechanisms and modes. For example, enzymes with long binding cavities offer numerous prerequisite binding sites that may be visited by an inhibitor during migration from a bulk solution to the destination site. Drug design can use these prerequisite sites as new structural targets. However, identifying these ephemeral sites is challenging. Here, we introduce a new method called NetBinder for the systematic identification and classification of prerequisite binding sites at atomic resolution. NetBinder is based on atomistic simulations of the full inhibitor binding process and provides a networking framework on which to select the most important binding modes and uncover the entire binding mechanism, including previously undiscovered events. NetBinder was validated by a study of the binding mechanism of blebbistatin (a potent inhibitor) to myosin 2 (a promising target for cancer chemotherapy). Myosin 2 is a good test enzyme because, like other potential targets, it has a long internal binding cavity that provides blebbistatin with numerous potential prerequisite binding sites. The mechanism proposed by NetBinder of myosin 2 structural changes during blebbistatin binding shows excellent agreement with experimentally determined binding sites and structural changes. While NetBinder was tested on myosin 2, it may easily be adopted to other proteins with long internal cavities, such as G-protein-coupled receptors or ion channels, the most popular current drug targets. NetBinder provides a new paradigm for drug design by a network-based elucidation of binding mechanisms at an atomic resolution.
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| 19. |
- Bloor, Sanjay, et al.
(författare)
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The GAMBIT Universal Model Machine : from Lagrangians to likelihoods
- 2021
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Ingår i: European Physical Journal C. - : Springer Nature. - 1434-6044 .- 1434-6052. ; 81:12
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Tidskriftsartikel (refereegranskat)abstract
- We introduce the GAMBIT Universal Model Machine (GUM), a tool for automatically generating code for the global fitting software framework GAMBIT, based on Lagrangian-level inputs. GUM accepts models written symbolically in FeynRules and SARAH formats, and can use either tool along with MadG rap h and CaIcHEP to generate GAMBIT model, collider, dark matter, decay and spectrum code, as well as GAMBIT interfaces to corresponding versions of SPheno, micrOMEGAs, Pythia and Vevacious (C++). In this paper we describe the features, methods, usage, pathways, assumptions and current limitations of GUM. We also give a fully worked example, consisting of the addition of a Majorana fermion simplified dark matter model with a scalar mediator to GAMBIT via GUM, and carry out a corresponding fit.
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| 20. |
- Brasko, Csilla, et al.
(författare)
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Intelligent image-based in situ single-cell isolation
- 2018
-
Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Quantifying heterogeneities within cell populations is important for many fields including cancer research and neurobiology; however, techniques to isolate individual cells are limited. Here, we describe a high-throughput, non-disruptive, and cost-effective isolation method that is capable of capturing individually targeted cells using widely available techniques. Using high-resolution microscopy, laser microcapture microscopy, image analysis, and machine learning, our technology enables scalable molecular genetic analysis of single cells, targetable by morphology or location within the sample.
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