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Sökning: WFRF:(Berglund Åke)

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11.
  • Berglund, Eva Caroline, et al. (författare)
  • A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
  • 2022
  • Ingår i: Frontiers in Medicine. - Lausanne, Switzerland : Frontiers Media SA. - 2296-858X. ; 9, s. 1-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Genomic Medicine Sweden, aims to evaluate whether combined application of WGS and WTS (WGTS) is technically feasible and can be implemented as an efficient diagnostic tool in patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In addition to clinical impact assessment, a health-economic evaluation of such strategy will be performed. Methods and Analysis: The study comprises four phases (i.e., retrospective, prospective, real-time validation, and follow-up) including approximately 700 adult and pediatric Swedish AML and ALL patients. Results of WGS for tumor (90×) and normal/germline (30×) samples as well as WTS for tumors only will be compared to current standard of care diagnostics. Primary study endpoints are diagnostic efficiency and improved diagnostic yield. Secondary endpoints are technical and clinical feasibility for routine implementation, clinical utility, and health-economic impact. Discussion: Data from this national multi-center study will be used to evaluate clinical performance of the integrated WGTS diagnostic workflow compared with standard of care. The study will also elucidate clinical and health-economic impacts of a combined WGTS strategy when implemented in routine clinical care. Clinical Trial Registration: [https://doi.org/10.1186/ISRCTN66987142], identifier [ISRCTN66987142].
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18.
  • Berglund, Sten, 1947-, et al. (författare)
  • Prospects for the new democracies in Eastern Europe
  • 1994. - 2
  • Ingår i: The new democracies in Eastern Europe. - Aldershot : Edward Elgar. - 1852789328 ; , s. 238-252
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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19.
  • Berglund, Sten, 1947-, et al. (författare)
  • The breakdown of communism in Eastern Europe
  • 1994. - 2
  • Ingår i: The new democracies in Eastern Europe. - Aldershot : Edward Elgar. - 1852789328 ; , s. 1-13
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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20.
  • Berglund, Sten, 1947-, et al. (författare)
  • The evolution of party systems in Eastern Europe
  • 1992
  • Ingår i: Communist Studies and Transition Politics. - : Informa UK Limited. - 1352-3279 .- 1743-9116. ; 8:1, s. 148-159
  • Tidskriftsartikel (refereegranskat)abstract
    • The Stalinist and neo-Stalinist system of government was imposed on Eastern Europe by the leading member of the Soviet bloc. It was a centralized and authoritarian system that was capable of transformation only within boundaries defined by the ruling communist parties. The revolution of 1989-90 was a byproduct of a permanent legitimacy crisis in Eastern Europe compounded by a series of serious political and economic mistakes. In the aftermath of the anti-communist revolution, a new process of evolution away from the Stalinist system has been entered upon, in which the party systems of Eastern Europe have undergone profound change, as new cleavages have appeared and old cleavages have reasserted themselves.
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