| 51. |
- Dahlberg, Anna-Karin, et al.
(författare)
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Recovery discrepancies of OH-PBDEs and polybromophenols in human plasma and cat serum versus herring and long-tailed duck plasma
- 2014
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Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 94, s. 97-103
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Tidskriftsartikel (refereegranskat)abstract
- Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been identified as metabolites of polybrominated diphenyl ethers (PBDEs) and/or as natural products. The OH-PBDEs and polybromophenols have come into focus over the last decade due to their abundance in biota and their potential adverse health effects. The present recovery study aims to validate a commonly used method (published by Hovander et al. 2000) for OH-PBDE analysis in human plasma. Further, the authors intended to determine the method's applicability to serum/plasma matrices from other species than humans. The investigated matrices were human plasma, cat serum, herring- and long-tailed duck plasma. The recovery study included nine OH-PBDEs, four polybromophenols and three methoxylated PBDEs (MeO-PBDEs). Five replicates of each matrix were spiked with these compounds at two dose levels; a low dose (0.5 ng) and a high dose (5 ng) and were cleaned up according to the Hovander method. The recovery of OH-PBDEs and polybromophenols in human plasma and cat serum were high and reproducible at both dose levels whereas the recovery for herring and long-tailed duck plasma were low and insufficient with great variability amongst OH-PBDE congeners at both dose levels. Our data show that the method can be fully applied to matrices like human plasma and cat serum but not for herring and long-tailed duck plasma without further method development. Hence care needs to be taken when applying the method onto other blood matrices without validation since the present study have demonstrated that the recoveries may differ amongst OH-PBDE congeners and specie.
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Educare 2011:1 : Tema: Svenska med didaktisk inriktning
- 2011
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Tema: Svenska med didaktisk inriktning Innehåll: Förord Lotta Bergman Den friska boken och den sjuka läsaren: Om litteratur som medicin Magnus Persson; Lyssnandets århundrade? Att lyssna på den talande boken Kent Adelmann; Kroppen läser och skriver? Läsningens och skrivandets kroppslighet i ljuset av Merleau-Pontys kroppsfilosofi Cecilia Nielsen; Texter, språk och skrivande med utgångspunkt i de nya kurs- och ämnesplanerna i svenska Annbritt Palo & Lena Manderstedt; Den retoriska arbetsprocessens betydelse för möjligheten att framstå med starkt och trovärdigt ethos i muntlig framställning Cecilia Olsson Jers; Vad kan vi lära oss av berättelser? Det fiktivas funktion i svenska som främmande språk Lisa Källström
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| 53. |
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Educare 2011:2 : Tema: Välfärdsstat i omvandling: reglerad barndom – oregerlig ungdom?
- 2011
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Tema: Välfärdsstat i omvandling: reglerad barndom – oregerlig ungdom? Förord - Ove Sernhede & Ingegerd Tallberg Broman Discursive Tensions on the Landscape of Modern Childhood - Patrick J. Ryan Dokumentation, styrning och kontroll i den svenska skolan - Lisa Asp-Onsjö “Soft governance” i förskolans utvecklingssamtal - Ann-Marie Markström En skolas implementering av kamratmedling - Ingela Kolfjord Social mobilization or street crimes: Two strategies among young urban outcasts in contemporary Sweden - Philip Lalander & Ove Sernhede Vem är egentligen expert? Hiphop som utbildningspolitik och progressiv pedagogik i USA - Johan Söderman
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| 60. |
- Gao, Yu, et al.
(författare)
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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
- 2022
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Ingår i: Immunity. - : Elsevier. - 1074-7613 .- 1097-4180. ; 55:9, s. 1732-1746.e5
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Tidskriftsartikel (refereegranskat)abstract
- Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.
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