| 31. |
- Wadbring, Ingela, 1964, et al.
(författare)
-
Introduktion till en 25-åring
- 2005
-
Ingår i: Bergström, Annika; Wadbring, Ingela & Weibull, Lennart (red) Nypressat. Ett kvartssekel med svenska dagstidningsläsare. - Göteborg : Göteborg University. - 9188212300 ; , s. 11-18
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
- Wadbring, Ingela, 1964-, et al.
(författare)
-
Medieanvändningen och dess mekanismer
- 2019. - 2
-
Ingår i: Handbok i journalistikforskning. - Lund : Studentlitteratur AB. - 9789144124636 ; , s. 365-378
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
- Wahlström, Annika, 1975, et al.
(författare)
-
Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism
- 2024
-
Ingår i: NATURE COMMUNICATIONS. - 2041-1723. ; 15:1
-
Tidskriftsartikel (refereegranskat)abstract
- Alterations in gut microbiota composition are suggested to contribute to cardiometabolic diseases, in part by producing bioactive molecules. Some of the metabolites are produced by very low abundant bacterial taxa, which largely have been neglected due to limits of detection. However, the concentration of microbially produced metabolites from these taxa can still reach high levels and have substantial impact on host physiology. To explore this concept, we focused on the generation of secondary bile acids by 7 alpha-dehydroxylating bacteria and demonstrated that addition of a very low abundant bacteria to a community can change the metabolic output dramatically. We show that Clostridium scindens converts cholic acid into the secondary bile acid deoxycholic acid (DCA) very efficiently even though the abundance of C. scindens is low, but still detectable by digital droplet PCR. We also show that colonization of germ-free female mice with a community containing C. scindens induces DCA production and affects host metabolism. Finally, we show that DCA correlates with impaired glucose metabolism and a worsened lipid profile in individuals with type 2 diabetes, which implies that this metabolic pathway may contribute to the development of cardiometabolic disease. Secondary bile acids are microbially produced metabolites linked to metabolic diseases. A challenge in microbiota research is to understand how bacteria collaborate to produce such bioactive molecules. Here, the authors show that adding a single low-abundance bacterial species to a community can significantly affect the metabolic output and host physiology.
|
|
| 38. |
- Östgren, Carl Johan, et al.
(författare)
-
Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study.
- 2023
-
Ingår i: Cardiovascular diabetology. - : BioMed Central (BMC). - 1475-2840. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort.The 30,154 study participants, 50-64years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of stenosis and coronary artery calcium score (CACS) were determined by coronary computed tomography angiography. Total atherosclerotic burden was assessed in the 11 clinically most relevant segments using the Segment Involvement Score and as the presence of any coronary atherosclerosis. The presence of atherosclerotic plaque in the carotid arteries was determined by ultrasound examination.Study participants with prediabetes (n=4804, 16.0%) or diabetes (n=2282, 7.6%) had greater coronary artery plaque burden, more coronary stenosis and higher CACS than normoglycaemic participants (all, p<0.01). Among male participants with diabetes 35.3% had CACS≥100 compared to 16.1% among normoglycaemic participants. For women, the corresponding figures were 8.9% vs 6.1%. The prevalence of atherosclerosis in the coronary arteries was higher in participants with previously undetected diabetes than prediabetes, but lower than in patients with known diabetes. The prevalence of any plaque in the carotid arteries was higher in participants with prediabetes or diabetes than in normoglycaemic participants.In this large population-based cohort of currently asymptomatic people, the atherosclerotic burden in the coronary and carotid arteries increased with increasing degree of dysglycaemia. The finding that the atherosclerotic burden in the coronary arteries in the undetected diabetes category was midway between the prediabetes category and patients with known diabetes may have implications for screening strategies and tailored prevention interventions for people with dysglycaemia in the future.
|
|
| 39. |
|
|
| 40. |
- Andersson, Ulrika, 1977, et al.
(författare)
-
En brokig gemenskap (inledningskapitel)
- 2017
-
Ingår i: En brokig gemenskap. - Göteborg : SOM-institutet vid Göteborgs universitet. - 0284-4788. - 9789189673403 ; , s. 9-28
-
Bokkapitel (refereegranskat)abstract
- I detta kapitel fokuseras graden av livstillfredställelse bland invånarna i Västra Götaland, vilka samhällsfrågor som upplevs vara mest oroande, hur regioninvånarna bedömer att de lagstiftande organen i regionen sköter sina arbeten mer generellt och arbetet inom några olika ansvarsområden mer specifikt samt vilket förtroende de har för sina folkvalda politiker. Kapitlet baseras på 2016 års västsvenska SOM-undersökning.
|
|
