| 41. |
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| 42. |
- Cederwall, Bo, et al.
(författare)
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MEASUREMENT OF ULTRA-FAST GAMMA-RAY TRANSITIONS FROM HEAVY-ION COMPOUND NUCLEUS REACTIONS
- 1995
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 354:2-3, s. 591-594
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Tidskriftsartikel (refereegranskat)abstract
- A method for correcting target-thickness-induced Doppler broadening in gamma-ray spectra from weakly populated, very short-lived (femtosecond) states is presented. The method is illustrated by an analysis of superdeformed transitions in Dy-152,Dy-153 for which the validity of the procedure could be verified consistently from previous lifetime measurements in Dy-152. Furthermore, estimates of the superdeformed lifetimes, previously not measured in Dy-153, are obtained.
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| 43. |
- Cederwall, Bo, et al.
(författare)
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NEW FEATURES OF SUPERDEFORMED BANDS IN HG-194
- 1994
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 72:20, s. 3150-3153
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Tidskriftsartikel (refereegranskat)abstract
- Two new features of superdeformed (SD) bands in the A almost-equal-to 190 region emerge from a study of Hg-194 with the Gammasphere detector array. A decrease of the dynamic moment of inertia is observed for rotational frequencies HBARomega greater-than-or-equal-to 0.4 MeV, confirming long standing expectations based on mean field calculations with pairing. Evidence for a small staggering in the SD transition energies is also observed, suggesting the presence of terms with fourfold symmetry in the SD Hamiltonian.
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| 44. |
- Cederwall, Bo, et al.
(författare)
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NEW OBLATE BAND IN HG-196 WITH QUENCHED M1 STRENGTH
- 1993
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 47:6, s. R2443-R2446
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in the nucleUs Hg-196 were populated in the reaction (Os(Be,5n))-Os-192 at a beam energy of 65 MeV. A regular rotational-like DELTAI = 1 band has been observed up to an excitation energy of E* almost-equal-to 8.7 MeV and spin I almost-equal-to 30hBAR. This is the second observation of a band of this character in a mercury isotope. The experimental results are compared with mean field calculations and semiclassical estimates based on the Donau-Frauendorf formalism. The mercury bands show significantly lower B(M1)/B(E2) branching ratios as compared with similar bands in light lead nuclei. This difference may be more readily explained by a difference in single-particle structure rather than by large differences in deformation between the lead and mercury configurations.
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| 45. |
- Cederwall, Bo, et al.
(författare)
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PROPERTIES OF SUPERDEFORMED BANDS IN DY-153
- 1995
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 346:3-4, s. 244-250
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Tidskriftsartikel (refereegranskat)abstract
- Two new superdeformed (SD) bands in Dy-153, in addition to the three previously observed, have been studied with the GAMMASPHERE detector array. Assignments to single-neutron orbits in the SD potential are made based on the band properties. Evidence for a band interaction at very high spins, possibly involving the first N = 7 proton intruder orbital, is observed in the strongest populated SD band. Furthermore, evidence far a Delta I = 2 staggering is also found in this SD band.
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| 46. |
- de Kleer, I. M., et al.
(författare)
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Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity
- 2004
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Ingår i: Ann Rheum Dis. - : BMJ. - 0003-4967. ; 63:10, s. 1318-26
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To evaluate the safety and efficacy of autologous stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA). DESIGN: Retrospective analysis of follow up data on 34 children with JIA who were treated with ASCT in nine different European transplant centres. Rheumatological evaluation employed a modified set of core criteria. Immunological reconstitution and infectious complications were monitored at three month intervals after transplantation. RESULTS: Clinical follow up ranged from 12 to 60 months. Eighteen of the 34 patients (53%) with a follow up of 12 to 60 months achieved complete drug-free remission. Seven of these patients had previously failed treatment with anti-TNF. Six of the 34 patients (18%) showed a partial response (ranging from 30% to 70% improvement) and seven (21%) were resistant to ASCT. Infectious complications were common. There were three cases of transplant related mortality (9%) and two of disease related mortality (6%). CONCLUSIONS: ASCT in severely ill patients with JIA induces a drug-free remission of the disease and a profound increase in general wellbeing in a substantial proportion of patients, but the procedure carries a significant mortality risk. The following adjustments are proposed for future protocols: (1) elimination of total body irradiation from the conditioning regimen; (2) prophylactic administration of antiviral drugs and intravenous immunoglobulins until there is a normal CD4+ T cell count.
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| 47. |
- Dianatinasab, Mostafa, et al.
(författare)
-
Adherence to a Western dietary pattern and risk of bladder cancer : A pooled analysis of 13 cohort studies of the Bladder Cancer Epidemiology and Nutritional Determinants international study
- 2020
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 147:12, s. 3394-3403
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Tidskriftsartikel (refereegranskat)abstract
- Little is known about the association of diet with risk of bladder cancer. This might be due to the fact that the majority of studies have focused on single food items, rather than dietary patterns, which may better capture any influence of diet on bladder cancer risk. We aimed to investigate the association between a measure of Western dietary pattern and bladder cancer risk. Associations between adherence to a Western dietary pattern and risk of developing bladder cancer were assessed by pooling data from 13 prospective cohort studies in the “BLadder cancer Epidemiology and Nutritional Determinants” (BLEND) study and applying Cox regression analysis. Dietary data from 580 768 study participants, including 3401 incident cases, and 577 367 noncases were analyzed. A direct and significant association was observed between higher adherence to a Western dietary pattern and risk of bladder cancer (hazard ratio (HR) comparing highest with lowest tertile scores: 1.54, 95% confidence interval (CI): 1.37, 1.72; P-trend =.001). This association was observed for men (HR comparing highest with lowest tertile scores: 1.72; 95% CI: 1.51, 1.96; P-trend =.001), but not women (P-het =.001). Results were consistent with HR above 1.00 after stratification on cancer subtypes (nonmuscle-invasive and muscle-invasive bladder cancer). We found evidence that adherence to a Western dietary pattern is associated with an increased risk of bladder cancer for men but not women.
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| 48. |
- Dianatinasab, Mostafa, et al.
(författare)
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The association between meat and fish consumption and bladder cancer risk : a pooled analysis of 11 cohort studies
- 2021
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 36:8, s. 781-792
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Tidskriftsartikel (refereegranskat)abstract
- Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was pooled and analysed to investigate the potential associations between total red meat and products, red meat, processed meat, poultry and total fish and BC risk. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox regression models stratified on cohort. Overall, an increased BC risk was found for high intake of organ meat (HR comparing highest with lowest tertile: 1.18, 95% CI: 1.03, 1.36, p-trend = 0.03). On the contrary, a marginally inverse association was observed for total fish intake and BC risk among men (HR comparing highest with lowest tertile: 0.79, 95% CI 0.65, 0.97, p-trend = 0.04). No associations were observed for other meat sources. Results of this prospective study suggest that organ meat consumption may be associated with BC development. Replication in large-scale prospective studies and investigation of possible causal mechanisms is needed.
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| 49. |
- Djoussé, L, et al.
(författare)
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Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease.
- 2003
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Ingår i: American Journal of Medical Genetics. Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 119A:3, s. 279-82
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Tidskriftsartikel (refereegranskat)abstract
- Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. Past studies have shown that the size of expanded CAG repeat is inversely associated with age at onset (AO) of HD. It is not known whether the normal Huntington allele size influences the relation between the expanded repeat and AO of HD. Data collected from two independent cohorts were used to test the hypothesis that the unexpanded CAG repeat interacts with the expanded CAG repeat to influence AO of HD. In the New England Huntington Disease Center Without Walls (NEHD) cohort of 221 HD affected persons and in the HD-MAPS cohort of 533 HD affected persons, we found evidence supporting an interaction between the expanded and unexpanded CAG repeat sizes which influences AO of HD (P = 0.08 and 0.07, respectively). The association was statistically significant when both cohorts were combined (P = 0.012). The estimated heritability of the AO residual was 0.56 after adjustment for normal and expanded repeats and their interaction. An analysis of tertiles of repeats sizes revealed that the effect of the normal allele is seen among persons with large HD repeat sizes (47-83). These findings suggest that an increase in the size of the normal repeat may mitigate the expression of the disease among HD affected persons with large expanded CAG repeats.
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| 50. |
- Ettema, Thijs J G, et al.
(författare)
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Molecular characterization of a conserved archaeal copper resistance (cop) gene cluster and its copper-responsive regulator in Sulfolobus solfataricus P2.
- 2006
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Ingår i: Microbiology. - : Microbiology Society. - 1350-0872 .- 1465-2080. ; 152:Pt 7, s. 1969-79
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Tidskriftsartikel (refereegranskat)abstract
- Using a comparative genomics approach, a copper resistance gene cluster has been identified in multiple archaeal genomes. The cop cluster is predicted to encode a metallochaperone (CopM), a P-type copper-exporting ATPase (CopA) and a novel, archaea-specific transcriptional regulator (CopT) which might control the expression of the cop genes. Sequence analysis revealed that CopT has an N-terminal DNA-binding helix-turn-helix domain and a C-terminal TRASH domain; TRASH is a novel domain which has recently been proposed to be uniquely involved in metal-binding in sensors, transporters and trafficking proteins in prokaryotes. The present study describes the molecular characterization of the cop gene cluster in the thermoacidophilic crenarchaeon Sulfolobus solfataricus. The polycistronic copMA transcript was found to accumulate in response to growth-inhibiting copper concentrations, whereas copT transcript abundance appeared to be constitutive. DNA-binding assays revealed that CopT binds to the copMA promoter at multiple sites, both upstream and downstream of the predicted TATA-BRE site. Copper was found to specifically modulate the affinity of DNA binding by CopT. This study describes a copper-responsive operon in archaea, a new family of archaeal DNA-binding proteins, and supports the idea that this domain plays a prominent role in the archaeal copper response. A model is proposed for copper-responsive transcriptional regulation of the copMA gene cluster.
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