| 31. |
- Johnsson, Anna, et al.
(författare)
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Physical activity and survival following breast cancer
- 2019
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Ingår i: European Journal of Cancer Care. - : Hindawi Limited. - 1365-2354 .- 0961-5423. ; 28:4
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION:Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.METHODS:From a prospective population-based cohort of Swedish women, we included 847 women, aged 34-84 years, who were diagnosed with breast cancer from 1992 to 2012. A PA score was calculated based on three different questions regarding self-reported PA. Cox proportional hazard model was used to estimate the association between PA and mortality.RESULTS:A significant association between PA score and all-cause mortality was observed, in a dose-response manner (ptrend = 0.01). The mortality was clearly lower in the most active compared to the least active group (hazard ratio 0.29, 95% confidence intervals 0.09-0.90). A subgroup analysis showed that the improved survival was only seen in women over 55 years of age at diagnosis.CONCLUSION:Physical activity, which is a modifiable lifestyle factor, should be encouraged after breast cancer diagnosis, especially in women with post-menopausal breast cancer.
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| 32. |
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| 33. |
- Larsson, Martin, et al.
(författare)
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Innovativa energieffektiva växthus - designade för lågtempererade energikällor och värmeåtervinning
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Lågtempererad restvärme är i dag en underutnyttjad resurs i samhället trots stor tillgång. I den här förstudien har växthus studerats, dvs system med stort behov av värmeenergi under delar av året. Projektet studerade teoretiskt ett växthuskoncept som använder lågvärdiga (30 – 40 °C) externa och interna värmekällor för uppvärmning, samt nyttjandet av frikyla (daggpunkt ca 25–10 °C) via termiskt lager för avfuktning. Syftet med förstudien är att skapa förutsättningar för hållbar och konkurrenskraftig växthusodling i Sverige genom synergier mellan olika branscher och tekniker. Som möjliggörare föreslås ett nytt koncept, som utvecklas för växthusodling, där energi- och odlingseffektivitet samspelar. Genom att utvärdera konceptet avser förstudien besvara frågeställningar om hur energieffektiv teknik dels kan minska energibehovet för växthus, dels använda sig av lågtempererade värmekällor, i kombination med värmeåtervinning, samtidigt som klimatet i växthuset styrs så odlingskapaciteten och CO2-gödsling förbättras. Resultatet visar att potentialen är mycket årstidsberoende och mycket beroende av hur stor värmekällan från växtbelysning är. Värmeåtervinning av växthusets interna värme kan minska värmeenergibehovet med ca 85% och växthuset kan använda lågtempererad värmekälla på ca 30–40 °C. Ytterligare resultat är att produktionen även kan ökas med ca 30–50% (beroende på årstid) med effektiv CO2-gödning och bättre klimat för växterna.
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| 34. |
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| 35. |
- Lindell, MJ, et al.
(författare)
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Monitoring of persistent organic pollutants (POPs): Examples from Lake Vattern, Sweden
- 2001
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Ingår i: Ambio: a Journal of Human Environment. - 0044-7447. ; 30:8, s. 545-551
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Tidskriftsartikel (refereegranskat)abstract
- Lake Vattern in southern Sweden is a large oligotrophic lake with high surface to catchment area ratio (ca. 0.4) and a water residence time of 60 years. The lake combines sensitivity to atmospheric POP-pollution with general susceptibility for effects of POPs and slow concentration decline. Time series, from the 1960s until 1996, of PCBs and DDT in fish and data on TCDD in sediment of L. Vattern are presented and compared to other large lakes. The long time dataset of POPs in Arctic char (Salvelinus salvelinus) shows a significant annual decline of about 5% for PCBs and 13% for DDT. These rates are in agreement with other studies. Nutrients as well as biological effects and factors affecting the fate of POPs in oligotrophic lakes with long residence times are discussed. We propose that oligotrophic clear lakes are important ecosystems for monitoring POPs in biota.
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| 36. |
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| 37. |
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| 38. |
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| 39. |
- Nilsson, Anna-Lena, et al.
(författare)
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Serological Evaluation of Possible Exposure to Ljungan Virus and Related Parechovirus in Autoimmune (Type 1) Diabetes in Children
- 2015
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Ingår i: Journal of Medical Virology. - : Wiley. - 0146-6615 .- 1096-9071. ; 87:7, s. 1130-1140
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Tidskriftsartikel (refereegranskat)abstract
- Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n=69) with healthy controls (n=294), all from the Jamtland County in Sweden, using an exploratory suspension multiplex immunoassay for IgM and IgG against 26 peptides of LV, human parechoviruses (HPeV), Aichi virus and poliovirus in relation to a radiobinding assay (RBA) for antibodies against LV and InfluenzaA/H1N1pdm09. Islet autoantibodies and HLA-DQ genotypes were also determined. 1) All five LV-peptide antibodies correlated to each other (P<0.001) in the suspension multiplex IgM- and IgG-antibody assay; 2) The LV-VP1_31-60-IgG correlated with insulin autoantibodies alone (P=0.007) and in combination with HLA-DQ8 overall (P=0.022) as well as with HLA-DQ 8/8 and 8/X subjects (P=0.013); 3) RBA detected LV antibodies correlated with young age at diagnosis (P<0.001) and with insulin autoantibodies (P<0.001) especially in young HLA-DQ8 subjects (P=0.004); 4) LV-peptide-VP1_31-60-IgG correlated to RBA LV antibodies (P=0.009); 5) HPeV3-peptide-IgM and -IgG showed inter-peptide correlations (P<0.001) but only HPeV3-VP1_1-30-IgG (P<0.001) and VP1_95-124-IgG (P=0.009) were related to RBA LV antibodies without relation to insulin autoantibody positivity (P=0.072 and P=0.486, respectively). Both exploratory suspension multiplex IgG to LV-peptide VP1_31-60 and RBA detected LV antibodies correlated with insulin autoantibodies and HLA-DQ8 suggesting possible role in type 1 diabetes. It remains to be determined if cross-reactivity or concomitant exposure to LV and HPeV3 contributes to the seroprevalence. J. Med. Virol. 87:1130-1140, 2015.
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| 40. |
- Olsson, Maja, 1975, et al.
(författare)
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Increased expression of aquaporin 3 in atopic eczema.
- 2006
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Ingår i: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 61:9, s. 1132-7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Dry skin in atopic eczema depends on increased water loss. The mechanisms behind this are poorly understood. The aim of this work was to identify genes that may contribute to water loss in eczema. METHODS: Affymetrix DNA microarrays U133A were used to analyse gene expression in skin biopsies from 10 patients with atopic eczema and 10 healthy controls. RESULTS: DNA microarray analysis showed up-regulation of 262 genes and down-regulation of 129 genes in atopic eczema. The known functions of these genes were analysed using Gene Ontology to identify genes that could contribute to increased water loss. This led to identification of aquaporin 3 (AQP3), which has a key role in hydrating healthy epidermis. Increased expression of AQP3 was found in eczema compared with healthy skin. This was confirmed with real-time polymerase chain reaction (P<0.001). In healthy skin, epidermal AQP3 immunoreactivity was weak and mainly found in the stratum basale. A gradient was formed with decreasing AQP3 staining in the lower layers of the stratum spinosum. By contrast, in acute and chronic atopic eczema strong AQP3 staining was found in both the stratum basale and the stratum spinosum. CONCLUSIONS: Aquaporin 3 is the predominant aquaporin in human skin. Increased expression and altered cellular distribution of AQP3 is found in eczema and this may contribute to water loss.
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